ESCO2 | OmnibusX

Name	Number of supported studies	Average coverage
transit amplifying cell	3 studies	23% ± 5%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of ESCO2 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	79%	247.97	1429 / 1809	85%	3.80	403 / 472
stomach	65%	78.14	235 / 359	97%	6.74	276 / 286
intestine	56%	112.32	537 / 966	95%	5.73	502 / 527
esophagus	44%	99.07	634 / 1445	99%	7.76	182 / 183
lung	56%	44.70	324 / 578	87%	3.94	1002 / 1155
bladder	33%	11.29	7 / 21	88%	3.92	441 / 504
breast	26%	11.23	121 / 459	87%	3.77	976 / 1118
ovary	17%	15.57	31 / 180	90%	3.18	387 / 430
uterus	9%	5.88	16 / 170	96%	6.09	441 / 459
pancreas	39%	12.49	128 / 328	66%	1.46	118 / 178
tonsil	0%	0	0 / 0	100%	8.21	45 / 45
lymph node	0%	0	0 / 0	97%	6.22	28 / 29
adrenal gland	82%	54.51	211 / 258	14%	0.48	33 / 230
spleen	93%	112.87	225 / 241	0%	0	0 / 0
liver	44%	30.35	100 / 226	35%	0.81	143 / 406
peripheral blood	58%	520.98	542 / 929	0%	0	0 / 0
brain	10%	3.00	259 / 2642	49%	1.95	342 / 705
adipose	37%	17.70	442 / 1204	0%	0	0 / 0
prostate	22%	8.79	54 / 245	13%	0.25	66 / 502
thymus	19%	7.20	121 / 653	15%	0.76	93 / 605
kidney	18%	16.62	16 / 89	15%	0.30	136 / 901
heart	22%	7.80	189 / 861	0%	0	0 / 0
blood vessel	19%	7.16	258 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	5%	0.06	4 / 80
muscle	1%	0.23	7 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0002244	Biological process	hematopoietic progenitor cell differentiation
GO_0007062	Biological process	sister chromatid cohesion
GO_0007059	Biological process	chromosome segregation
GO_0007064	Biological process	mitotic sister chromatid cohesion
GO_0034421	Biological process	post-translational protein acetylation
GO_0006302	Biological process	double-strand break repair
GO_0071168	Biological process	protein localization to chromatin
GO_0006275	Biological process	regulation of DNA replication
GO_0010369	Cellular component	chromocenter
GO_0005654	Cellular component	nucleoplasm
GO_0005794	Cellular component	Golgi apparatus
GO_0005721	Cellular component	pericentric heterochromatin
GO_0030054	Cellular component	cell junction
GO_0005694	Cellular component	chromosome
GO_0000785	Cellular component	chromatin
GO_0001741	Cellular component	XY body
GO_0035861	Cellular component	site of double-strand break
GO_0005634	Cellular component	nucleus
GO_0004468	Molecular function	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
GO_0061733	Molecular function	peptide-lysine-N-acetyltransferase activity
GO_0016407	Molecular function	acetyltransferase activity
GO_0046872	Molecular function	metal ion binding
GO_0008080	Molecular function	N-acetyltransferase activity
GO_0005515	Molecular function	protein binding

Gene name	ESCO2
Protein name	N-acetyltransferase ESCO2 (EC 2.3.1.-) (Establishment factor-like protein 2) (EFO2) (EFO2p) (hEFO2) (Establishment of cohesion 1 homolog 2) (ECO1 homolog 2) Establishment of sister chromatid cohesion N-acetyltransferase 2
Synonyms
Description	FUNCTION: Acetyltransferase required for the establishment of sister chromatid cohesion . Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 . .
Accessions	ENST00000519637.1 ENST00000305188.13 [Q56NI9-1] ENST00000397418.4 [Q56NI9-2] Q56NI9 H0YB88 E5RFE4 ENST00000518262.5 ENST00000522378.5 E5RIE3 E5RFP7 ENST00000523566.5

ESCO2 report