ZGRF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032508Biological processDNA duplex unwinding
GO_0000725Biological processrecombinational repair
GO_0006302Biological processdouble-strand break repair
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0016853Molecular functionisomerase activity
GO_0016787Molecular functionhydrolase activity
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0043139Molecular function5'-3' DNA helicase activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameZGRF1
Protein nameHCG21296, isoform CRA_a (Zinc finger GRF-type containing 1)
5'-3' DNA helicase ZGRF1 (EC 5.6.2.3) (GRF-type zinc finger domain-containing protein 1)
Zinc finger GRF-type containing 1
SynonymshCG_21296
C4orf21
DescriptionFUNCTION: 5'-3' DNA helicase which is recruited to sites of DNA damage and promotes repair of replication-blocking DNA lesions through stimulation of homologous recombination (HR) . Promotes HR by directly stimulating RAD51-mediated strand exchange activity . Not required to load RAD51 at sites of DNA damage but promotes recombinational repair after RAD51 recruitment . Also promotes HR by positively regulating EXO1-mediated DNA end resection of double-strand breaks . Required for recruitment of replication protein RPA2 to DNA damage sites . Promotes the initiation of the G2/M checkpoint but not its maintenance . Catalyzes Holliday junction branch migration and dissociation of D-loops and DNA flaps . .

AccessionsENST00000309071.9 [Q86YA3-4]
G3XAL8
ENST00000503172.5
ENST00000473015.5
D6REQ7
ENST00000445203.6 [Q86YA3-1]
I3L0G6
ENST00000612287.4 [Q86YA3-2]
D6REN9
ENST00000445413.6
ENST00000502805.1
ENST00000505019.6 [Q86YA3-1]
D6RB47
Q86YA3
ENST00000514770.5