RFWD3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0036297Biological processinterstrand cross-link repair
GO_0010212Biological processresponse to ionizing radiation
GO_0006974Biological processDNA damage response
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0031297Biological processreplication fork processing
GO_0031571Biological processmitotic G1 DNA damage checkpoint signaling
GO_2000001Biological processregulation of DNA damage checkpoint
GO_0005654Cellular componentnucleoplasm
GO_0090734Cellular componentsite of DNA damage
GO_0016605Cellular componentPML body
GO_0005737Cellular componentcytoplasm
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0097371Molecular functionMDM2/MDM4 family protein binding
GO_0002039Molecular functionp53 binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRFWD3
Protein nameRing finger and WD repeat domain 3
E3 ubiquitin-protein ligase RFWD3 (EC 2.3.2.27) (RING finger and WD repeat domain-containing protein 3) (RING finger protein 201)
SynonymsRNF201
DescriptionFUNCTION: E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage . Plays a key role in RPA-mediated DNA damage signaling and repair . Acts by mediating ubiquitination of the RPA complex (RPA1, RPA2 and RPA3 subunits) and RAD51 at stalled replication forks, leading to remove them from DNA damage sites and promote homologous recombination . Also mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint . May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome . In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53 . Required to translesion DNA synthesis across DNA-protein cross-link adducts by catalyzing ubiquitination of proteins on single-stranded DNA (ssDNA) . .

AccessionsENST00000361070.9
Q6PCD5
ENST00000572337.5
ENST00000575113.1
ENST00000571750.5
I3L284
I3L299
ENST00000576652.1
I3L2T2
ENST00000572990.5
I3L4I5