ZBTB7A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_2000677Biological processregulation of transcription regulatory region DNA binding
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0043249Biological processerythrocyte maturation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0006110Biological processregulation of glycolytic process
GO_0006338Biological processchromatin remodeling
GO_0097680Biological processdouble-strand break repair via classical nonhomologous end joining
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0006351Biological processDNA-templated transcription
GO_0042981Biological processregulation of apoptotic process
GO_0034504Biological processprotein localization to nucleus
GO_0060766Biological processnegative regulation of androgen receptor signaling pathway
GO_0051090Biological processregulation of DNA-binding transcription factor activity
GO_0045746Biological processnegative regulation of Notch signaling pathway
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0030183Biological processB cell differentiation
GO_0045444Biological processfat cell differentiation
GO_0070418Cellular componentDNA-dependent protein kinase complex
GO_0005737Cellular componentcytoplasm
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0046332Molecular functionSMAD binding
GO_0001222Molecular functiontranscription corepressor binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0035035Molecular functionhistone acetyltransferase binding
GO_0046872Molecular functionmetal ion binding
GO_0050681Molecular functionnuclear androgen receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameZBTB7A
Protein nameAlternative protein ZBTB7A
ZBTB7A protein (Zinc finger and BTB domain containing 7A, isoform CRA_a)
Zinc finger and BTB domain-containing protein 7A (Factor binding IST protein 1) (FBI-1) (Factor that binds to inducer of short transcripts protein 1) (HIV-1 1st-binding protein 1) (Leukemia/lymphoma-related factor) (POZ and Krueppel erythroid myeloid ontogenic factor) (POK erythroid myeloid ontogenic factor) (Pokemon) (Pokemon 1) (TTF-I-interacting peptide 21) (TIP21) (Zinc finger protein 857A)
SynonymsFBI1
LRF
hCG_2004107
ZNF857A
ZBTB7
DescriptionFUNCTION: Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation . Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions . Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms . That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 . Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (By similarity). Also directly interacts with transcription factors like SP1 to prevent their binding to DNA . Functions as an androgen receptor/AR transcriptional corepressor by recruiting NCOR1 and NCOR2 to the androgen response elements/ARE on target genes . Thereby, negatively regulates androgen receptor signaling and androgen-induced cell proliferation . Involved in the switch between fetal and adult globin expression during erythroid cells maturation . Through its interaction with the NuRD complex regulates chromatin at the fetal globin genes to repress their transcription . Specifically represses the transcription of the tumor suppressor ARF isoform from the CDKN2A gene (By similarity). Efficiently abrogates E2F1-dependent CDKN2A transactivation (By similarity). Regulates chondrogenesis through the transcriptional repression of specific genes via a mechanism that also requires histone deacetylation (By similarity). Regulates cell proliferation through the transcriptional regulation of genes involved in glycolysis . Involved in adipogenesis through the regulation of genes involved in adipocyte differentiation . Plays a key role in the differentiation of lymphoid progenitors into B and T lineages (By similarity). Promotes differentiation towards the B lineage by inhibiting the T-cell instructive Notch signaling pathway through the specific transcriptional repression of Notch downstream target genes (By similarity). Also regulates osteoclast differentiation (By similarity). May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ (By similarity). Recruited to double-strand break sites on damage DNA, interacts with the DNA-dependent protein kinase complex and directly regulates its stability and activity in DNA repair (By similarity). May also modulate the splicing activity of KHDRBS1 toward BCL2L1 in a mechanism which is histone deacetylase-dependent and thereby negatively regulates the pro-apoptotic effect of KHDRBS1 . .

AccessionsENST00000322357.9
ENST00000601588.1
O95365
L8E8Q6
Q8TB76