Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 1042.92 | 1445 / 1445 | 100% | 30.13 | 183 / 183 |
lung | 100% | 1313.30 | 578 / 578 | 100% | 25.80 | 1155 / 1155 |
ovary | 100% | 1321.47 | 180 / 180 | 100% | 24.43 | 430 / 430 |
brain | 100% | 823.93 | 2640 / 2642 | 100% | 24.77 | 705 / 705 |
breast | 100% | 1327.83 | 459 / 459 | 100% | 24.36 | 1115 / 1118 |
uterus | 100% | 1149.96 | 170 / 170 | 100% | 26.78 | 457 / 459 |
prostate | 100% | 1054.71 | 245 / 245 | 99% | 19.35 | 498 / 502 |
bladder | 100% | 1018.00 | 21 / 21 | 99% | 19.85 | 499 / 504 |
stomach | 100% | 832.46 | 359 / 359 | 99% | 22.70 | 283 / 286 |
intestine | 100% | 1218.77 | 966 / 966 | 99% | 22.32 | 521 / 527 |
thymus | 100% | 1101.99 | 653 / 653 | 99% | 18.43 | 598 / 605 |
pancreas | 100% | 631.12 | 327 / 328 | 99% | 15.99 | 176 / 178 |
kidney | 100% | 772.36 | 89 / 89 | 96% | 14.56 | 864 / 901 |
skin | 100% | 958.21 | 1806 / 1809 | 93% | 18.80 | 439 / 472 |
adrenal gland | 100% | 701.36 | 258 / 258 | 93% | 9.92 | 213 / 230 |
liver | 100% | 847.42 | 226 / 226 | 90% | 9.91 | 366 / 406 |
adipose | 100% | 1375.95 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 32.43 | 29 / 29 |
spleen | 100% | 1550.00 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 26.47 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.67 | 1 / 1 |
blood vessel | 100% | 888.44 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 99% | 465.54 | 792 / 803 | 0% | 0 | 0 / 0 |
heart | 96% | 453.29 | 829 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 96% | 1441.64 | 892 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 61% | 4.87 | 49 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0000724 | Biological process | double-strand break repair via homologous recombination |
GO_0010792 | Biological process | DNA double-strand break processing involved in repair via single-strand annealing |
GO_0016567 | Biological process | protein ubiquitination |
GO_0016055 | Biological process | Wnt signaling pathway |
GO_0035861 | Cellular component | site of double-strand break |
GO_0005634 | Cellular component | nucleus |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0019901 | Molecular function | protein kinase binding |
GO_0005515 | Molecular function | protein binding |
GO_0003697 | Molecular function | single-stranded DNA binding |
GO_0046872 | Molecular function | metal ion binding |
Gene name | RNF138 |
Protein name | RING-type E3 ubiquitin transferase (EC 2.3.2.27) E3 ubiquitin-protein ligase RNF138 (EC 2.3.2.27) (Nemo-like kinase-associated RING finger protein) (NLK-associated RING finger protein) (hNARF) (RING finger protein 138) (RING-type E3 ubiquitin transferase RNF138) E3 ubiquitin-protein ligase RNF138 (EC 2.3.2.27) (RING finger protein 138) (RING-type E3 ubiquitin transferase RNF138) |
Synonyms | HSD4 HSD-4 NARF |
Description | FUNCTION: E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination . Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination . Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination . According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP . Together with NLK, involved in the ubiquitination and degradation of TCF/LEF . Also exhibits auto-ubiquitination activity in combination with UBE2K . May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway . . |
Accessions | ENST00000577999.1 ENST00000257190.9 [Q8WVD3-2] J3KRU4 J3KSI2 ENST00000580499.1 ENST00000578107.5 Q8WVD3 J3QLQ3 ENST00000578914.1 J3QKM8 ENST00000261593.8 [Q8WVD3-1] |