RNF138 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0010792Biological processDNA double-strand break processing involved in repair via single-strand annealing
GO_0016567Biological processprotein ubiquitination
GO_0016055Biological processWnt signaling pathway
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0019901Molecular functionprotein kinase binding
GO_0005515Molecular functionprotein binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameRNF138
Protein nameRING-type E3 ubiquitin transferase (EC 2.3.2.27)
E3 ubiquitin-protein ligase RNF138 (EC 2.3.2.27) (Nemo-like kinase-associated RING finger protein) (NLK-associated RING finger protein) (hNARF) (RING finger protein 138) (RING-type E3 ubiquitin transferase RNF138)
E3 ubiquitin-protein ligase RNF138 (EC 2.3.2.27) (RING finger protein 138) (RING-type E3 ubiquitin transferase RNF138)
SynonymsHSD4
HSD-4
NARF
DescriptionFUNCTION: E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination . Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination . Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination . According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP . Together with NLK, involved in the ubiquitination and degradation of TCF/LEF . Also exhibits auto-ubiquitination activity in combination with UBE2K . May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway . .

AccessionsENST00000577999.1
ENST00000257190.9 [Q8WVD3-2]
J3KRU4
J3KSI2
ENST00000580499.1
ENST00000578107.5
Q8WVD3
J3QLQ3
ENST00000578914.1
J3QKM8
ENST00000261593.8 [Q8WVD3-1]