ASF1A | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	4 studies	23% ± 9%	Explore
epithelial cell	4 studies	27% ± 10%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of ASF1A at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	1251.01	2642 / 2642	100%	48.80	705 / 705
ovary	100%	924.70	180 / 180	100%	22.80	430 / 430
prostate	100%	647.29	245 / 245	100%	23.91	502 / 502
esophagus	100%	715.69	1444 / 1445	100%	26.79	183 / 183
breast	100%	654.98	459 / 459	100%	32.85	1117 / 1118
thymus	100%	908.51	653 / 653	100%	39.60	603 / 605
lung	100%	801.45	576 / 578	100%	30.58	1154 / 1155
uterus	100%	782.45	170 / 170	100%	27.11	457 / 459
bladder	100%	816.86	21 / 21	99%	25.08	499 / 504
adrenal gland	100%	988.68	258 / 258	99%	27.41	227 / 230
stomach	100%	654.61	359 / 359	99%	21.20	282 / 286
pancreas	99%	450.84	325 / 328	99%	15.81	177 / 178
intestine	100%	702.16	966 / 966	98%	22.05	515 / 527
kidney	100%	551.87	89 / 89	97%	16.02	872 / 901
liver	99%	405.00	223 / 226	97%	15.84	395 / 406
skin	100%	798.58	1806 / 1809	89%	17.09	420 / 472
lymph node	0%	0	0 / 0	100%	20.09	29 / 29
spleen	100%	837.59	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	24.45	45 / 45
ureter	0%	0	0 / 0	100%	7.76	1 / 1
adipose	100%	604.24	1203 / 1204	0%	0	0 / 0
muscle	100%	648.24	801 / 803	0%	0	0 / 0
blood vessel	100%	714.55	1331 / 1335	0%	0	0 / 0
heart	97%	645.05	837 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	79%	12.72	63 / 80
peripheral blood	74%	477.54	687 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0140861	Biological process	DNA repair-dependent chromatin remodeling
GO_0006335	Biological process	DNA replication-dependent chromatin assembly
GO_0031297	Biological process	replication fork processing
GO_0006281	Biological process	DNA repair
GO_0006334	Biological process	nucleosome assembly
GO_0042692	Biological process	muscle cell differentiation
GO_0001649	Biological process	osteoblast differentiation
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_0000785	Cellular component	chromatin
GO_0035861	Cellular component	site of double-strand break
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding
GO_0140713	Molecular function	histone chaperone activity
GO_0042393	Molecular function	histone binding
GO_0003682	Molecular function	chromatin binding

Gene name	ASF1A
Protein name	Histone chaperone ASF1A (Anti-silencing function protein 1 homolog A) (hAsf1) (hAsf1a) (CCG1-interacting factor A) (CIA) (hCIA)
Synonyms	CGI-98 HSPC146
Description	FUNCTION: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly . Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly . Promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks: acts by mediating histone replacement at DSBs, leading to recruitment of the MMS22L-TONSL complex and subsequent loading of RAD51 . Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' and acetylation at 'Lys-14' (H3K9me1K14ac) marks, and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol . Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit . .
Accessions	Q9Y294 ENST00000229595.6

ASF1A report