Name | Number of supported studies | Average coverage | |
---|---|---|---|
B cell | 23 studies | 26% ± 8% | |
plasmacytoid dendritic cell | 14 studies | 31% ± 11% | |
naive B cell | 14 studies | 22% ± 6% | |
memory B cell | 14 studies | 21% ± 5% | |
endothelial cell | 10 studies | 25% ± 9% | |
oligodendrocyte precursor cell | 8 studies | 27% ± 13% | |
glutamatergic neuron | 7 studies | 42% ± 27% | |
epithelial cell | 6 studies | 34% ± 8% | |
pericyte | 6 studies | 19% ± 3% | |
oligodendrocyte | 6 studies | 31% ± 8% | |
neuron | 5 studies | 31% ± 13% | |
basal cell | 5 studies | 26% ± 10% | |
astrocyte | 5 studies | 31% ± 11% | |
retinal pigment epithelial cell | 4 studies | 54% ± 22% | |
fibroblast | 4 studies | 16% ± 1% | |
GABAergic neuron | 4 studies | 48% ± 18% | |
interneuron | 4 studies | 42% ± 25% | |
microglial cell | 3 studies | 20% ± 1% | |
immature B cell | 3 studies | 26% ± 5% | |
ciliated cell | 3 studies | 25% ± 5% | |
dendritic cell | 3 studies | 19% ± 2% | |
smooth muscle cell | 3 studies | 18% ± 2% | |
macrophage | 3 studies | 18% ± 2% | |
transit amplifying cell | 3 studies | 37% ± 24% | |
erythroblast | 3 studies | 24% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 1940.26 | 1445 / 1445 | 100% | 18.73 | 183 / 183 |
breast | 100% | 1753.45 | 459 / 459 | 100% | 16.69 | 1114 / 1118 |
uterus | 100% | 2034.14 | 170 / 170 | 99% | 20.36 | 456 / 459 |
lung | 100% | 1763.39 | 577 / 578 | 99% | 16.38 | 1148 / 1155 |
bladder | 100% | 1461.14 | 21 / 21 | 98% | 13.33 | 495 / 504 |
brain | 99% | 1170.39 | 2618 / 2642 | 98% | 9.74 | 693 / 705 |
intestine | 100% | 2090.18 | 966 / 966 | 97% | 12.34 | 512 / 527 |
stomach | 100% | 1089.56 | 358 / 359 | 97% | 12.33 | 277 / 286 |
ovary | 100% | 1568.76 | 180 / 180 | 96% | 7.99 | 411 / 430 |
thymus | 100% | 1748.63 | 653 / 653 | 95% | 7.79 | 577 / 605 |
pancreas | 97% | 822.94 | 318 / 328 | 98% | 11.00 | 175 / 178 |
skin | 100% | 2594.97 | 1809 / 1809 | 95% | 15.80 | 447 / 472 |
liver | 100% | 2031.91 | 226 / 226 | 91% | 8.06 | 370 / 406 |
kidney | 100% | 1359.33 | 89 / 89 | 90% | 8.90 | 814 / 901 |
prostate | 100% | 1640.88 | 245 / 245 | 90% | 5.98 | 453 / 502 |
adrenal gland | 99% | 995.06 | 256 / 258 | 86% | 7.60 | 198 / 230 |
lymph node | 0% | 0 | 0 / 0 | 100% | 20.71 | 29 / 29 |
spleen | 100% | 3166.33 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 20.25 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.92 | 1 / 1 |
adipose | 100% | 1953.60 | 1203 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1390.80 | 1333 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 1229.40 | 800 / 803 | 0% | 0 | 0 / 0 |
heart | 99% | 1221.93 | 856 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 96% | 23.03 | 77 / 80 |
peripheral blood | 60% | 1345.03 | 560 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0016925 | Biological process | protein sumoylation |
GO_0032204 | Biological process | regulation of telomere maintenance |
GO_0006974 | Biological process | DNA damage response |
GO_0000722 | Biological process | telomere maintenance via recombination |
GO_0044828 | Biological process | negative regulation by host of viral genome replication |
GO_0000724 | Biological process | double-strand break repair via homologous recombination |
GO_0051984 | Biological process | positive regulation of chromosome segregation |
GO_0140588 | Biological process | chromatin looping |
GO_0090398 | Biological process | cellular senescence |
GO_0000775 | Cellular component | chromosome, centromeric region |
GO_0097431 | Cellular component | mitotic spindle pole |
GO_0016607 | Cellular component | nuclear speck |
GO_0000803 | Cellular component | sex chromosome |
GO_0005654 | Cellular component | nucleoplasm |
GO_0030915 | Cellular component | Smc5-Smc6 complex |
GO_0016605 | Cellular component | PML body |
GO_0000781 | Cellular component | chromosome, telomeric region |
GO_0035061 | Cellular component | interchromatin granule |
GO_0035861 | Cellular component | site of double-strand break |
GO_0005634 | Cellular component | nucleus |
GO_0003697 | Molecular function | single-stranded DNA binding |
GO_0000217 | Molecular function | DNA secondary structure binding |
GO_0031625 | Molecular function | ubiquitin protein ligase binding |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
GO_0003684 | Molecular function | damaged DNA binding |
GO_0016887 | Molecular function | ATP hydrolysis activity |
Gene name | SMC6 |
Protein name | Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (hSMC6) Structural maintenance of chromosomes 6 |
Synonyms | SMC6L1 |
Description | FUNCTION: Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome . . |
Accessions | ENST00000446852.5 ENST00000428868.1 C9JMN1 ENST00000430591.1 ENST00000448223.7 [Q96SB8-1] Q96SB8 ENST00000351948.8 [Q96SB8-1] A0A087WWI9 A0A2S1ZR87 A0A0A0MRY1 ENST00000402989.5 [Q96SB8-1] H7C3J8 C9JEF0 A0A2S1ZR79 ENST00000381272.5 ENST00000621152.4 |