SMC6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016925Biological processprotein sumoylation
GO_0032204Biological processregulation of telomere maintenance
GO_0006974Biological processDNA damage response
GO_0000722Biological processtelomere maintenance via recombination
GO_0044828Biological processnegative regulation by host of viral genome replication
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0051984Biological processpositive regulation of chromosome segregation
GO_0140588Biological processchromatin looping
GO_0090398Biological processcellular senescence
GO_0000775Cellular componentchromosome, centromeric region
GO_0097431Cellular componentmitotic spindle pole
GO_0016607Cellular componentnuclear speck
GO_0000803Cellular componentsex chromosome
GO_0005654Cellular componentnucleoplasm
GO_0030915Cellular componentSmc5-Smc6 complex
GO_0016605Cellular componentPML body
GO_0000781Cellular componentchromosome, telomeric region
GO_0035061Cellular componentinterchromatin granule
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0000217Molecular functionDNA secondary structure binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0003684Molecular functiondamaged DNA binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameSMC6
Protein nameStructural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (hSMC6)
Structural maintenance of chromosomes 6
SynonymsSMC6L1
DescriptionFUNCTION: Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome . .

AccessionsENST00000446852.5
ENST00000428868.1
C9JMN1
ENST00000430591.1
ENST00000448223.7 [Q96SB8-1]
Q96SB8
ENST00000351948.8 [Q96SB8-1]
A0A087WWI9
A0A2S1ZR87
A0A0A0MRY1
ENST00000402989.5 [Q96SB8-1]
H7C3J8
C9JEF0
A0A2S1ZR79
ENST00000381272.5
ENST00000621152.4