SMARCA5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0006281Biological processDNA repair
GO_0016479Biological processnegative regulation of transcription by RNA polymerase I
GO_0000183Biological processrDNA heterochromatin formation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0006346Biological processDNA methylation-dependent heterochromatin formation
GO_0006974Biological processDNA damage response
GO_1990830Biological processcellular response to leukemia inhibitory factor
GO_1905213Biological processnegative regulation of mitotic chromosome condensation
GO_0006338Biological processchromatin remodeling
GO_0031507Biological processheterochromatin formation
GO_0006334Biological processnucleosome assembly
GO_0045945Biological processpositive regulation of transcription by RNA polymerase III
GO_0045740Biological processpositive regulation of DNA replication
GO_0045943Biological processpositive regulation of transcription by RNA polymerase I
GO_0006355Biological processregulation of DNA-templated transcription
GO_0006275Biological processregulation of DNA replication
GO_0006352Biological processDNA-templated transcription initiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0140374Biological processantiviral innate immune response
GO_0043596Cellular componentnuclear replication fork
GO_0005730Cellular componentnucleolus
GO_0110016Cellular componentB-WICH complex
GO_0008623Cellular componentCHRAC
GO_0005654Cellular componentnucleoplasm
GO_0005677Cellular componentchromatin silencing complex
GO_0001650Cellular componentfibrillar center
GO_0090536Cellular componentNoRC complex
GO_0090535Cellular componentWICH complex
GO_0005721Cellular componentpericentric heterochromatin
GO_0016590Cellular componentACF complex
GO_0016589Cellular componentNURF complex
GO_0000793Cellular componentcondensed chromosome
GO_0035861Cellular componentsite of double-strand break
GO_0031213Cellular componentRSF complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0004386Molecular functionhelicase activity
GO_0042393Molecular functionhistone binding
GO_0140751Molecular functionhistone octamer slider activity
GO_0005524Molecular functionATP binding
GO_0031491Molecular functionnucleosome binding
GO_0140658Molecular functionATP-dependent chromatin remodeler activity
GO_0008094Molecular functionATP-dependent activity, acting on DNA
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameSMARCA5
Protein nameSWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H)
Uncharacterized protein SMARCA5
SynonymsSNF2H
WCRF135
DescriptionFUNCTION: Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity . Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails . Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template . Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes . The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner . The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template . Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex . Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase . Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (By similarity). Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure . The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription . Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (By similarity). Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). .

AccessionsQ4W5H1
ENST00000283131.4
Q4W5G3
O60264