KAT5 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KAT5 at tissue level.

III. Associated gene sets

GO_1905337Biological processpositive regulation of aggrephagy
GO_0042149Biological processcellular response to glucose starvation
GO_0071333Biological processcellular response to glucose stimulus
GO_1901985Biological processpositive regulation of protein acetylation
GO_1905691Biological processlipid droplet disassembly
GO_2000779Biological processregulation of double-strand break repair
GO_0032703Biological processnegative regulation of interleukin-2 production
GO_0010212Biological processresponse to ionizing radiation
GO_0045087Biological processinnate immune response
GO_0006302Biological processdouble-strand break repair
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0140861Biological processDNA repair-dependent chromatin remodeling
GO_0006289Biological processnucleotide-excision repair
GO_0006974Biological processDNA damage response
GO_0006978Biological processDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO_0045663Biological processpositive regulation of myoblast differentiation
GO_0062033Biological processpositive regulation of mitotic sister chromatid segregation
GO_0071392Biological processcellular response to estradiol stimulus
GO_0000132Biological processestablishment of mitotic spindle orientation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0010867Biological processpositive regulation of triglyceride biosynthetic process
GO_0018394Biological processpeptidyl-lysine acetylation
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_2000042Biological processnegative regulation of double-strand break repair via homologous recombination
GO_0022008Biological processneurogenesis
GO_0042981Biological processregulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0042753Biological processpositive regulation of circadian rhythm
GO_0010508Biological processpositive regulation of autophagy
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_1902036Biological processregulation of hematopoietic stem cell differentiation
GO_1905168Biological processpositive regulation of double-strand break repair via homologous recombination
GO_0006915Biological processapoptotic process
GO_0090398Biological processcellular senescence
GO_1902425Biological processpositive regulation of attachment of mitotic spindle microtubules to kinetochore
GO_0035092Biological processsperm DNA condensation
GO_0021915Biological processneural tube development
GO_0045591Biological processpositive regulation of regulatory T cell differentiation
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0007286Biological processspermatid development
GO_0051726Biological processregulation of cell cycle
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000812Cellular componentSwr1 complex
GO_0005730Cellular componentnucleolus
GO_0097431Cellular componentmitotic spindle pole
GO_0000786Cellular componentnucleosome
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0000776Cellular componentkinetochore
GO_0005654Cellular componentnucleoplasm
GO_0035267Cellular componentNuA4 histone acetyltransferase complex
GO_0032777Cellular componentpiccolo histone acetyltransferase complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0000785Cellular componentchromatin
GO_0035861Cellular componentsite of double-strand break
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0140064Molecular functionpeptide crotonyltransferase activity
GO_0106226Molecular functionpeptide 2-hydroxyisobutyryltransferase activity
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0061733Molecular functionpeptide-lysine-N-acetyltransferase activity
GO_0003682Molecular functionchromatin binding
GO_0046972Molecular functionhistone H4K16 acetyltransferase activity
GO_0140065Molecular functionpeptide butyryltransferase activity
GO_0003712Molecular functiontranscription coregulator activity
GO_0016407Molecular functionacetyltransferase activity
GO_0010485Molecular functionhistone H4 acetyltransferase activity
GO_0043999Molecular functionhistone H2AK5 acetyltransferase activity
GO_0046872Molecular functionmetal ion binding
GO_0004402Molecular functionhistone acetyltransferase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0043998Molecular functionhistone H2A acetyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKAT5
Protein nameHistone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (HIV-1 Tat interactive protein) (Lysine acetyltransferase 5) (Protein 2-hydroxyisobutyryltransferase KAT5) (EC 2.3.1.-) (Protein acetyltransferase KAT5) (EC 2.3.1.-) (Protein crotonyltransferase KAT5) (EC 2.3.1.-) (cPLA(2)-interacting protein)
Histone acetyltransferase (EC 2.3.1.48)
Lysine acetyltransferase 5
SynonymsHTATIP
TIP60
DescriptionFUNCTION: Catalytic subunit of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H2A and H4 . Histone acetylation alters nucleosome-DNA interactions and promotes interaction of the modified histones with other proteins which positively regulate transcription . The NuA4 histone acetyltransferase complex is required for the activation of transcriptional programs associated with proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair . The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR): the complex inhibits TP53BP1 binding to chromatin via MBTD1, which recognizes and binds histone H4 trimethylated at 'Lys-20' (H4K20me), and KAT5 that catalyzes acetylation of 'Lys-15' of histone H2A (H2AK15ac), thereby blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks . Also involved in DSB repair by mediating acetylation of 'Lys-5' of histone H2AX (H2AXK5ac), promoting NBN/NBS1 assembly at the sites of DNA damage . The NuA4 complex plays a key role in hematopoietic stem cell maintenance and is required to maintain acetylated H2A.Z/H2AZ1 at MYC target genes (By similarity). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone hyperacetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome . Also acetylates non-histone proteins, such as BMAL1, ATM, AURKB, CHKA, CGAS, ERCC4/XPF, LPIN1, NDC80/HEC1, NR1D2, RAN, SOX4, FOXP3, SQSTM1, ULK1 and RUBCNL/Pacer . Directly acetylates and activates ATM . Promotes nucleotide excision repair (NER) by mediating acetylation of ERCC4/XPF, thereby promoting formation of the ERCC4-ERCC1 complex . Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2 . Acts as a regulator of regulatory T-cells (Treg) by catalyzing FOXP3 acetylation, thereby promoting FOXP3 transcriptional repressor activity . Involved in skeletal myoblast differentiation by mediating acetylation of SOX4 . Catalyzes acetylation of APBB1/FE65, increasing its transcription activator activity . Promotes transcription elongation during the activation phase of the circadian cycle by catalyzing acetylation of BMAL1, promoting elongation of circadian transcripts (By similarity). Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy: phosphorylated at Ser-86 by GSK3 under starvation conditions, leading to activate acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer . Acts as a regulator of the cGAS-STING innate antiviral response by catalyzing acetylation the N-terminus of CGAS, thereby promoting CGAS DNA-binding and activation . Also regulates lipid metabolism by mediating acetylation of CHKA or LPIN1 . Promotes lipolysis of lipid droplets following glucose deprivation by mediating acetylation of isoform 1 of CHKA, thereby promoting monomerization of CHKA and its conversion into a tyrosine-protein kinase . Acts as a regulator of fatty-acid-induced triacylglycerol synthesis by catalyzing acetylation of LPIN1, thereby promoting the synthesis of diacylglycerol . In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA) and 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), and is able to mediate protein crotonylation and 2-hydroxyisobutyrylation, respectively . Acts as a key regulator of chromosome segregation and kinetochore-microtubule attachment during mitosis by mediating acetylation or crotonylation of target proteins . Catalyzes acetylation of AURKB at kinetochores, increasing AURKB activity and promoting accurate chromosome segregation in mitosis . Acetylates RAN during mitosis, promoting microtubule assembly at mitotic chromosomes . Acetylates NDC80/HEC1 during mitosis, promoting robust kinetochore-microtubule attachment . Catalyzes crotonylation of MAPRE1/EB1, thereby ensuring accurate spindle positioning in mitosis . .

AccessionsENST00000530605.5
E9PRL6
E9PMG8
ENST00000377046.7 [Q92993-1]
Q92993
ENST00000534681.1
ENST00000530446.5 [Q92993-4]
H0YEP0
ENST00000534650.5
ENST00000528198.5
E9PRM3
H0YEG3
E9PRS1
ENST00000531880.1
ENST00000533596.1
ENST00000534104.5
ENST00000352980.8 [Q92993-2]
E9PJI1
ENST00000341318.9 [Q92993-3]