RIF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045814Biological processnegative regulation of gene expression, epigenetic
GO_0006281Biological processDNA repair
GO_1990830Biological processcellular response to leukemia inhibitory factor
GO_0006974Biological processDNA damage response
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0031509Biological processsubtelomeric heterochromatin formation
GO_0000723Biological processtelomere maintenance
GO_0043247Biological processtelomere maintenance in response to DNA damage
GO_2000042Biological processnegative regulation of double-strand break repair via homologous recombination
GO_2001034Biological processpositive regulation of double-strand break repair via nonhomologous end joining
GO_0045830Biological processpositive regulation of isotype switching
GO_0035019Biological processsomatic stem cell population maintenance
GO_0001939Cellular componentfemale pronucleus
GO_0005886Cellular componentplasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0051233Cellular componentspindle midzone
GO_0140445Cellular componentchromosome, telomeric repeat region
GO_0005737Cellular componentcytoplasm
GO_0001940Cellular componentmale pronucleus
GO_0000793Cellular componentcondensed chromosome
GO_0000785Cellular componentchromatin
GO_0031965Cellular componentnuclear membrane
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRIF1
Protein nameTelomere-associated protein RIF1 (Rap1-interacting factor 1 homolog)
Replication timing regulatory factor 1
Synonyms
DescriptionFUNCTION: Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs . In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 . Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs . Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs . In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase . Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). .

AccessionsENST00000444746.7 [Q5UIP0-1]
H7BZN3
ENST00000243326.9 [Q5UIP0-1]
Q5UIP0
ENST00000454583.6
ENST00000453091.6 [Q5UIP0-2]
ENST00000414861.6
H7C2B5
ENST00000430328.6 [Q5UIP0-2]
ENST00000428287.6 [Q5UIP0-2]