CYREN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006303Biological processdouble-strand break repair via nonhomologous end joining
GO_2001033Biological processnegative regulation of double-strand break repair via nonhomologous end joining
GO_0033152Biological processimmunoglobulin V(D)J recombination
GO_0035861Cellular componentsite of double-strand break
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCYREN
Protein nameCell cycle regulator of NHEJ
Cell cycle regulator of non-homologous end joining (Cell cycle regulator of NHEJ) (Modulator of retrovirus infection homolog)
SynonymsMRI
C7orf49
DescriptionFUNCTION: Cell-cycle-specific regulator of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair, which can act both as an activator or inhibitor of NHEJ, depending on the cell cycle phase . Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present . Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination . Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70 . In contrast, acts as an activator of NHEJ during G1 phase of the cell cycle: promotes classical NHEJ in G1 phase cells via multivalent interactions that increase the affinity of DNA damage response proteins for DSB-associated chromatin. Also involved in immunoglobulin V(D)J recombination (By similarity). May also act as an indirect regulator of proteasome (By similarity). .

AccessionsQ9BWK5
ENST00000393114.8 [Q9BWK5-1]
ENST00000424142.5 [Q9BWK5-3]
ENST00000617987.1 [Q9BWK5-4]
ENST00000430372.1
C9JKC7
ENST00000483029.2 [Q9BWK5-3]
ENST00000620897.4 [Q9BWK5-3]