TONSL | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of TONSL at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	523.43	180 / 180	100%	26.11	429 / 430
uterus	100%	489.72	170 / 170	99%	22.22	456 / 459
skin	100%	955.73	1806 / 1809	99%	18.32	466 / 472
bladder	100%	657.05	21 / 21	98%	17.82	495 / 504
esophagus	98%	608.36	1417 / 1445	100%	25.35	183 / 183
stomach	100%	613.23	359 / 359	98%	20.17	280 / 286
intestine	100%	876.55	966 / 966	98%	18.72	515 / 527
prostate	100%	621.51	244 / 245	93%	6.46	469 / 502
lung	97%	464.88	558 / 578	96%	14.48	1106 / 1155
breast	97%	414.29	446 / 459	95%	12.56	1059 / 1118
thymus	100%	970.44	653 / 653	87%	5.87	527 / 605
pancreas	93%	257.63	305 / 328	87%	8.72	155 / 178
liver	98%	359.63	222 / 226	76%	6.56	307 / 406
adrenal gland	100%	621.12	257 / 258	72%	4.59	166 / 230
brain	86%	394.87	2264 / 2642	76%	5.73	535 / 705
kidney	98%	425.91	87 / 89	49%	2.78	438 / 901
lymph node	0%	0	0 / 0	100%	19.15	29 / 29
spleen	100%	1118.47	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	24.89	45 / 45
ureter	0%	0	0 / 0	100%	24.77	1 / 1
eye	0%	0	0 / 0	99%	11.00	79 / 80
adipose	96%	301.69	1154 / 1204	0%	0	0 / 0
heart	91%	259.53	783 / 861	0%	0	0 / 0
blood vessel	82%	199.15	1100 / 1335	0%	0	0 / 0
peripheral blood	79%	846.29	731 / 929	0%	0	0 / 0
muscle	15%	24.62	122 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0006325	Biological process	chromatin organization
GO_0000724	Biological process	double-strand break repair via homologous recombination
GO_0031297	Biological process	replication fork processing
GO_0071168	Biological process	protein localization to chromatin
GO_0043596	Cellular component	nuclear replication fork
GO_0042555	Cellular component	MCM complex
GO_0035101	Cellular component	FACT complex
GO_0005662	Cellular component	DNA replication factor A complex
GO_0005654	Cellular component	nucleoplasm
GO_0016604	Cellular component	nuclear body
GO_0035861	Cellular component	site of double-strand break
GO_0005737	Cellular component	cytoplasm
GO_0005515	Molecular function	protein binding
GO_0042393	Molecular function	histone binding
GO_0140566	Molecular function	histone reader activity

Gene name	TONSL
Protein name	Tonsoku-like protein (Inhibitor of kappa B-related protein) (I-kappa-B-related protein) (IkappaBR) (NF-kappa-B inhibitor-like protein 2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2)
Synonyms	IKBR NFKBIL2
Description	FUNCTION: Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks . The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication . It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs . Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination . Within the complex, TONSL acts as a histone reader, which recognizes and binds newly synthesized histones following their replacement by histone chaperones . Specifically binds histone H4 lacking methylation at 'Lys-20' (H4K20me0) and histone H3.1 . .
Accessions	Q96HA7 ENST00000409379.8 [Q96HA7-1]

TONSL report