DGCR8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006974Biological processDNA damage response
GO_0072091Biological processregulation of stem cell proliferation
GO_2000633Biological processpositive regulation of pre-miRNA processing
GO_0031053Biological processprimary miRNA processing
GO_0005730Cellular componentnucleolus
GO_0098978Cellular componentglutamatergic synapse
GO_0070877Cellular componentmicroprocessor complex
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_0035861Cellular componentsite of double-strand break
GO_0042803Molecular functionprotein homodimerization activity
GO_0042802Molecular functionidentical protein binding
GO_0140517Molecular functionprotein-RNA adaptor activity
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0020037Molecular functionheme binding
GO_0046872Molecular functionmetal ion binding
GO_0070878Molecular functionprimary miRNA binding
GO_0005515Molecular functionprotein binding
GO_0003725Molecular functiondouble-stranded RNA binding

IV. Literature review

[source]
Gene nameDGCR8
Protein nameAlternative protein DGCR8
Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8)
DGCR8 microprocessor complex subunit
SynonymsLP4941
C22orf12
DGCRK6
DescriptionFUNCTION: Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs . The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding . Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing . Involved in the silencing of embryonic stem cell self-renewal (By similarity). .

AccessionsQ8WYQ5
A0A994J4Y2
ENST00000704821.1
ENST00000407755.2 [Q8WYQ5-3]
ENST00000457069.2 [Q8WYQ5-1]
ENST00000704820.1
ENST00000351989.8 [Q8WYQ5-1]
ENST00000457069.2
L8E8Q8
A0A994J7P0
C9JSD5