ACTR2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	45 studies	51% ± 17%	Explore
B cell	41 studies	41% ± 12%	Explore
natural killer cell	41 studies	39% ± 12%	Explore
endothelial cell	41 studies	33% ± 12%	Explore
CD8-positive, alpha-beta T cell	37 studies	35% ± 12%	Explore
T cell	35 studies	33% ± 12%	Explore
CD4-positive, alpha-beta T cell	32 studies	34% ± 12%	Explore
pericyte	29 studies	25% ± 8%	Explore
classical monocyte	29 studies	58% ± 18%	Explore
dendritic cell	27 studies	52% ± 21%	Explore
fibroblast	27 studies	23% ± 7%	Explore
conventional dendritic cell	27 studies	63% ± 15%	Explore
regulatory T cell	26 studies	39% ± 10%	Explore
monocyte	25 studies	53% ± 20%	Explore
non-classical monocyte	24 studies	66% ± 13%	Explore
mast cell	21 studies	32% ± 15%	Explore
smooth muscle cell	21 studies	22% ± 5%	Explore
mature NK T cell	20 studies	37% ± 10%	Explore
memory B cell	20 studies	42% ± 9%	Explore
naive B cell	20 studies	38% ± 11%	Explore
plasmacytoid dendritic cell	20 studies	52% ± 15%	Explore
endothelial cell of lymphatic vessel	19 studies	29% ± 10%	Explore
myeloid cell	18 studies	54% ± 20%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	32% ± 10%	Explore
gamma-delta T cell	17 studies	42% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	36% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	46% ± 12%	Explore
epithelial cell	15 studies	36% ± 20%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	37% ± 11%	Explore
capillary endothelial cell	14 studies	28% ± 6%	Explore
microglial cell	14 studies	40% ± 16%	Explore
mucosal invariant T cell	14 studies	34% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	42% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	38% ± 12%	Explore
ciliated cell	12 studies	35% ± 16%	Explore
neutrophil	12 studies	40% ± 13%	Explore
glutamatergic neuron	12 studies	45% ± 24%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	42% ± 14%	Explore
endothelial cell of vascular tree	12 studies	25% ± 6%	Explore
myofibroblast cell	11 studies	22% ± 6%	Explore
endothelial cell of artery	11 studies	26% ± 9%	Explore
vein endothelial cell	11 studies	28% ± 7%	Explore
basal cell	10 studies	34% ± 17%	Explore
leukocyte	10 studies	44% ± 13%	Explore
connective tissue cell	9 studies	27% ± 14%	Explore
goblet cell	9 studies	30% ± 13%	Explore
GABAergic neuron	9 studies	40% ± 22%	Explore
astrocyte	9 studies	26% ± 7%	Explore
oligodendrocyte	9 studies	26% ± 7%	Explore
alveolar macrophage	8 studies	57% ± 14%	Explore
plasmablast	8 studies	42% ± 22%	Explore
secretory cell	8 studies	28% ± 11%	Explore
platelet	8 studies	28% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	45% ± 15%	Explore
abnormal cell	8 studies	27% ± 11%	Explore
neuron	8 studies	38% ± 14%	Explore
T follicular helper cell	8 studies	34% ± 7%	Explore
type I pneumocyte	7 studies	24% ± 6%	Explore
plasma cell	7 studies	33% ± 14%	Explore
mononuclear phagocyte	7 studies	56% ± 17%	Explore
precursor B cell	7 studies	52% ± 21%	Explore
innate lymphoid cell	7 studies	35% ± 7%	Explore
oligodendrocyte precursor cell	7 studies	27% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	32% ± 9%	Explore
hematopoietic precursor cell	6 studies	59% ± 21%	Explore
respiratory goblet cell	6 studies	25% ± 9%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	42% ± 13%	Explore
transit amplifying cell	6 studies	29% ± 16%	Explore
retinal ganglion cell	6 studies	46% ± 23%	Explore
hematopoietic stem cell	6 studies	42% ± 23%	Explore
lymphocyte	6 studies	41% ± 14%	Explore
immature B cell	6 studies	43% ± 12%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	45% ± 12%	Explore
interneuron	6 studies	41% ± 22%	Explore
CD4-positive helper T cell	5 studies	30% ± 14%	Explore
exhausted T cell	5 studies	47% ± 16%	Explore
pro-B cell	5 studies	50% ± 17%	Explore
brush cell	5 studies	35% ± 16%	Explore
club cell	5 studies	28% ± 15%	Explore
intermediate monocyte	5 studies	62% ± 20%	Explore
squamous epithelial cell	4 studies	39% ± 22%	Explore
pancreatic A cell	4 studies	38% ± 22%	Explore
progenitor cell	4 studies	42% ± 22%	Explore
enterocyte	4 studies	21% ± 6%	Explore
retina horizontal cell	4 studies	29% ± 6%	Explore
retinal cone cell	4 studies	24% ± 6%	Explore
retinal rod cell	4 studies	16% ± 1%	Explore
inflammatory macrophage	4 studies	48% ± 8%	Explore
granulocyte	4 studies	38% ± 22%	Explore
enteroendocrine cell	4 studies	30% ± 11%	Explore
T-helper 17 cell	4 studies	42% ± 10%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	42% ± 12%	Explore
double negative thymocyte	4 studies	51% ± 6%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	39% ± 15%	Explore
ionocyte	3 studies	33% ± 13%	Explore
monocyte-derived dendritic cell	3 studies	56% ± 28%	Explore
glomerular endothelial cell	3 studies	35% ± 4%	Explore
intestinal crypt stem cell	3 studies	24% ± 8%	Explore
retinal bipolar neuron	3 studies	25% ± 5%	Explore
GABAergic interneuron	3 studies	20% ± 4%	Explore
extravillous trophoblast	3 studies	36% ± 15%	Explore
amacrine cell	3 studies	25% ± 9%	Explore
adipocyte	3 studies	20% ± 4%	Explore
tissue-resident macrophage	3 studies	59% ± 13%	Explore
Mueller cell	3 studies	21% ± 3%	Explore
OFF-bipolar cell	3 studies	26% ± 10%	Explore
ON-bipolar cell	3 studies	28% ± 9%	Explore
rod bipolar cell	3 studies	28% ± 4%	Explore
germinal center B cell	3 studies	51% ± 7%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	24% ± 6%	Explore
type II pneumocyte	3 studies	26% ± 11%	Explore
pancreatic ductal cell	3 studies	56% ± 25%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	80% ± 8%	Explore
group 3 innate lymphoid cell	3 studies	45% ± 14%	Explore
granule cell	3 studies	25% ± 5%	Explore
T-helper 1 cell	3 studies	45% ± 7%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	39% ± 2%	Explore
mural cell	3 studies	31% ± 12%	Explore
luminal cell of prostate epithelium	3 studies	20% ± 5%	Explore
erythrocyte	3 studies	32% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	43% ± 15%	Explore
lung	19 studies	33% ± 14%	Explore
brain	19 studies	33% ± 18%	Explore
intestine	11 studies	25% ± 8%	Explore
kidney	8 studies	26% ± 7%	Explore
bone marrow	5 studies	43% ± 22%	Explore
eye	5 studies	25% ± 5%	Explore
adipose	5 studies	26% ± 8%	Explore
lymph node	5 studies	33% ± 6%	Explore
liver	5 studies	37% ± 9%	Explore
heart	4 studies	20% ± 1%	Explore
uterus	4 studies	37% ± 13%	Explore
pancreas	3 studies	45% ± 26%	Explore
placenta	3 studies	36% ± 14%	Explore
breast	3 studies	25% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
uterus	100%	6821.34	170 / 170	100%	218.25	459 / 459
esophagus	100%	9010.85	1444 / 1445	100%	232.42	183 / 183
breast	100%	8865.92	459 / 459	100%	287.74	1117 / 1118
lung	100%	10283.12	577 / 578	100%	266.52	1155 / 1155
ovary	100%	4869.32	180 / 180	100%	136.85	429 / 430
brain	99%	9715.30	2627 / 2642	100%	189.88	705 / 705
bladder	100%	7794.43	21 / 21	99%	222.42	501 / 504
stomach	100%	6010.56	359 / 359	99%	215.12	283 / 286
intestine	100%	9122.20	966 / 966	99%	232.21	521 / 527
thymus	100%	6761.22	652 / 653	99%	160.69	598 / 605
prostate	100%	6484.74	244 / 245	99%	160.80	496 / 502
skin	100%	13629.06	1805 / 1809	98%	227.49	461 / 472
kidney	100%	5798.37	89 / 89	96%	178.75	861 / 901
adrenal gland	100%	6703.40	257 / 258	93%	116.32	214 / 230
pancreas	91%	3436.16	299 / 328	99%	210.14	176 / 178
liver	97%	4066.11	219 / 226	92%	97.05	375 / 406
adipose	100%	10788.20	1204 / 1204	0%	0	0 / 0
blood vessel	100%	12248.36	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	429.03	29 / 29
spleen	100%	11002.80	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	213.41	45 / 45
ureter	0%	0	0 / 0	100%	71.02	1 / 1
muscle	99%	5325.18	797 / 803	0%	0	0 / 0
peripheral blood	99%	21510.31	919 / 929	0%	0	0 / 0
heart	93%	4565.55	799 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	90%	109.98	72 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0033206	Biological process	meiotic cytokinesis
GO_0060271	Biological process	cilium assembly
GO_0016344	Biological process	meiotic chromosome movement towards spindle pole
GO_0008356	Biological process	asymmetric cell division
GO_0007163	Biological process	establishment or maintenance of cell polarity
GO_0010592	Biological process	positive regulation of lamellipodium assembly
GO_0034314	Biological process	Arp2/3 complex-mediated actin nucleation
GO_2001032	Biological process	regulation of double-strand break repair via nonhomologous end joining
GO_0051653	Biological process	spindle localization
GO_0016482	Biological process	cytosolic transport
GO_1905168	Biological process	positive regulation of double-strand break repair via homologous recombination
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0071346	Biological process	cellular response to type II interferon
GO_0035578	Cellular component	azurophil granule lumen
GO_0005885	Cellular component	Arp2/3 protein complex
GO_0005576	Cellular component	extracellular region
GO_0016020	Cellular component	membrane
GO_0030478	Cellular component	actin cap
GO_0070062	Cellular component	extracellular exosome
GO_0005925	Cellular component	focal adhesion
GO_0015629	Cellular component	actin cytoskeleton
GO_1904813	Cellular component	ficolin-1-rich granule lumen
GO_0005829	Cellular component	cytosol
GO_0005938	Cellular component	cell cortex
GO_0005737	Cellular component	cytoplasm
GO_0042995	Cellular component	cell projection
GO_0035861	Cellular component	site of double-strand break
GO_0005634	Cellular component	nucleus
GO_0005200	Molecular function	structural constituent of cytoskeleton
GO_0051015	Molecular function	actin filament binding
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ACTR2
Protein name	Actin related protein 2 Actin-related protein 2 (Actin-like protein 2)
Synonyms	ARP2
Description	FUNCTION: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) . The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility . Seems to contact the pointed end of the daughter actin filament . In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation . In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA . The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) . .
Accessions	ENST00000260641.10 [P61160-1] A0A1B0GWH0 ENST00000471552.5 ENST00000476840.5 A0A1B0GWD0 Q8IY98 P61160 ENST00000377982.8 [P61160-2]

ACTR2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review