PAXX | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	36 studies	47% ± 15%	Explore
CD8-positive, alpha-beta T cell	33 studies	43% ± 15%	Explore
CD4-positive, alpha-beta T cell	28 studies	32% ± 9%	Explore
T cell	23 studies	34% ± 9%	Explore
plasmacytoid dendritic cell	21 studies	63% ± 16%	Explore
mature NK T cell	19 studies	49% ± 12%	Explore
regulatory T cell	18 studies	31% ± 7%	Explore
conventional dendritic cell	17 studies	28% ± 14%	Explore
gamma-delta T cell	16 studies	45% ± 15%	Explore
B cell	15 studies	23% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	50% ± 17%	Explore
endothelial cell	14 studies	27% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	50% ± 13%	Explore
memory B cell	14 studies	22% ± 4%	Explore
mucosal invariant T cell	14 studies	45% ± 14%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	41% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	26% ± 8%	Explore
naive B cell	13 studies	21% ± 4%	Explore
classical monocyte	12 studies	26% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	43% ± 13%	Explore
non-classical monocyte	11 studies	25% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	41% ± 18%	Explore
macrophage	10 studies	23% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	34% ± 6%	Explore
capillary endothelial cell	9 studies	21% ± 3%	Explore
endothelial cell of artery	8 studies	25% ± 5%	Explore
epithelial cell	8 studies	35% ± 18%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	43% ± 14%	Explore
pericyte	7 studies	20% ± 6%	Explore
dendritic cell	7 studies	39% ± 19%	Explore
vein endothelial cell	7 studies	22% ± 6%	Explore
basal cell	6 studies	27% ± 13%	Explore
fibroblast	6 studies	24% ± 8%	Explore
monocyte	6 studies	24% ± 5%	Explore
T follicular helper cell	6 studies	25% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	33% ± 10%	Explore
CD4-positive helper T cell	5 studies	22% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	41% ± 14%	Explore
innate lymphoid cell	5 studies	41% ± 14%	Explore
exhausted T cell	5 studies	52% ± 8%	Explore
smooth muscle cell	5 studies	20% ± 3%	Explore
ciliated cell	5 studies	30% ± 8%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	34% ± 10%	Explore
myofibroblast cell	4 studies	21% ± 3%	Explore
plasma cell	4 studies	30% ± 8%	Explore
abnormal cell	4 studies	26% ± 6%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	39% ± 7%	Explore
neuron	4 studies	28% ± 14%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	36% ± 0%	Explore
plasmablast	3 studies	37% ± 13%	Explore
leukocyte	3 studies	33% ± 6%	Explore
hematopoietic precursor cell	3 studies	35% ± 3%	Explore
glomerular endothelial cell	3 studies	23% ± 4%	Explore
common myeloid progenitor	3 studies	25% ± 9%	Explore
hematopoietic stem cell	3 studies	17% ± 1%	Explore
myeloid cell	3 studies	27% ± 11%	Explore
immature B cell	3 studies	23% ± 4%	Explore
mesothelial cell	3 studies	29% ± 13%	Explore
precursor B cell	3 studies	24% ± 9%	Explore
intraepithelial lymphocyte	3 studies	39% ± 4%	Explore
endothelial cell of vascular tree	3 studies	27% ± 1%	Explore
goblet cell	3 studies	22% ± 5%	Explore
group 3 innate lymphoid cell	3 studies	43% ± 8%	Explore
T-helper 17 cell	3 studies	29% ± 8%	Explore
connective tissue cell	3 studies	23% ± 5%	Explore
double negative thymocyte	3 studies	48% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	18 studies	31% ± 9%	Explore
lung	8 studies	24% ± 7%	Explore
intestine	4 studies	22% ± 10%	Explore
placenta	3 studies	21% ± 5%	Explore
kidney	3 studies	32% ± 8%	Explore
lymph node	3 studies	24% ± 3%	Explore
brain	3 studies	23% ± 1%	Explore
liver	3 studies	30% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	1319.27	180 / 180	100%	75.23	430 / 430
uterus	100%	1714.89	170 / 170	100%	117.80	459 / 459
brain	100%	2080.51	2639 / 2642	100%	99.26	705 / 705
thymus	100%	2290.31	653 / 653	100%	110.56	603 / 605
esophagus	100%	1377.00	1445 / 1445	99%	51.82	182 / 183
pancreas	100%	1156.23	328 / 328	99%	80.37	177 / 178
intestine	100%	1601.91	966 / 966	99%	90.17	524 / 527
stomach	100%	1333.93	359 / 359	99%	75.20	284 / 286
prostate	100%	2426.76	245 / 245	99%	86.96	498 / 502
skin	100%	1436.58	1808 / 1809	99%	67.95	465 / 472
bladder	100%	1571.62	21 / 21	98%	97.09	496 / 504
lung	100%	1883.01	577 / 578	98%	65.28	1135 / 1155
kidney	100%	1839.20	89 / 89	98%	50.28	883 / 901
adrenal gland	100%	1312.71	258 / 258	98%	57.60	225 / 230
breast	100%	1488.73	459 / 459	98%	76.91	1093 / 1118
liver	100%	1275.81	226 / 226	98%	59.21	396 / 406
eye	0%	0	0 / 0	100%	67.10	80 / 80
lymph node	0%	0	0 / 0	100%	118.63	29 / 29
spleen	100%	3613.60	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	92.07	45 / 45
ureter	0%	0	0 / 0	100%	195.37	1 / 1
adipose	100%	1218.58	1199 / 1204	0%	0	0 / 0
blood vessel	99%	1342.71	1327 / 1335	0%	0	0 / 0
heart	99%	991.48	855 / 861	0%	0	0 / 0
peripheral blood	98%	1440.87	910 / 929	0%	0	0 / 0
muscle	86%	436.70	693 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006974	Biological process	DNA damage response
GO_0006303	Biological process	double-strand break repair via nonhomologous end joining
GO_0005654	Cellular component	nucleoplasm
GO_0035861	Cellular component	site of double-strand break
GO_0043564	Cellular component	Ku70:Ku80 complex
GO_0005737	Cellular component	cytoplasm
GO_0070419	Cellular component	nonhomologous end joining complex
GO_0005634	Cellular component	nucleus
GO_0042803	Molecular function	protein homodimerization activity
GO_0005515	Molecular function	protein binding
GO_0060090	Molecular function	molecular adaptor activity
GO_0070182	Molecular function	DNA polymerase binding

IV. Literature review

[source]

Gene name	PAXX
Protein name	Protein PAXX (Paralog of XRCC4 and XLF) (XRCC4-like small protein)
Synonyms	XLS C9orf142
Description	FUNCTION: Non-essential DNA repair protein involved in DNA non-homologous end joining (NHEJ); participates in double-strand break (DSB) repair and V(D)J recombination . May act as a scaffold required for accumulation of the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at double-strand break sites and promote the assembly and/or stability of the NHEJ machinery . Involved in NHEJ by promoting the ligation of blunt-ended DNA ends . Together with NHEJ1/XLF, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends . Constitutes a non-essential component of classical NHEJ: has a complementary but distinct function with NHEJ1/XLF in DNA repair . Able to restrict infection by herpesvirus 1 (HSV-1) via an unknown mechanism . .
Accessions	Q9BUH6 ENST00000371620.4 [Q9BUH6-1]

PAXX report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review