UIMC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010212Biological processresponse to ionizing radiation
GO_0140861Biological processDNA repair-dependent chromatin remodeling
GO_0045739Biological processpositive regulation of DNA repair
GO_0006302Biological processdouble-strand break repair
GO_0006282Biological processregulation of DNA repair
GO_0007095Biological processmitotic G2 DNA damage checkpoint signaling
GO_0044818Biological processmitotic G2/M transition checkpoint
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005654Cellular componentnucleoplasm
GO_0070531Cellular componentBRCA1-A complex
GO_0016604Cellular componentnuclear body
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0070530Molecular functionK63-linked polyubiquitin modification-dependent protein binding
GO_0042393Molecular functionhistone binding
GO_0046872Molecular functionmetal ion binding
GO_0061649Molecular functionubiquitin-modified histone reader activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUIMC1
Protein nameUbiquitin interaction motif containing 1
BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Ubiquitin interaction motif-containing protein 1)
BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1)
SynonymsRXRIP110
RAP80
DescriptionFUNCTION: Ubiquitin-binding protein . Specifically recognizes and binds 'Lys-63'-linked ubiquitin . Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. .

AccessionsD6RDZ5
ENST00000506128.5 [Q96RL1-2]
D6R9M3
ENST00000509236.5
ENST00000507513.1
D6RC40
D6RCQ3
ENST00000512031.5
ENST00000428382.2
ENST00000510698.2 [Q96RL1-4]
ENST00000377227.8 [Q96RL1-1]
Q96RL1
ENST00000511320.6 [Q96RL1-1]