Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 13 studies | 28% ± 10% | |
GABAergic neuron | 7 studies | 36% ± 20% | |
microglial cell | 6 studies | 26% ± 6% | |
adipocyte | 6 studies | 22% ± 4% | |
fibroblast | 6 studies | 23% ± 5% | |
astrocyte | 6 studies | 32% ± 11% | |
oligodendrocyte | 6 studies | 27% ± 7% | |
macrophage | 6 studies | 25% ± 7% | |
interneuron | 5 studies | 37% ± 22% | |
natural killer cell | 5 studies | 16% ± 1% | |
endothelial cell of lymphatic vessel | 5 studies | 27% ± 6% | |
glutamatergic neuron | 5 studies | 52% ± 22% | |
oligodendrocyte precursor cell | 5 studies | 30% ± 11% | |
pericyte | 5 studies | 21% ± 7% | |
B cell | 4 studies | 23% ± 3% | |
neuron | 4 studies | 27% ± 11% | |
epithelial cell | 4 studies | 31% ± 11% | |
cardiac muscle cell | 4 studies | 21% ± 2% | |
lymphocyte | 4 studies | 24% ± 7% | |
monocyte | 4 studies | 24% ± 3% | |
smooth muscle cell | 4 studies | 21% ± 2% | |
naive B cell | 4 studies | 18% ± 2% | |
classical monocyte | 3 studies | 22% ± 2% | |
effector memory CD8-positive, alpha-beta T cell | 3 studies | 16% ± 1% | |
hematopoietic precursor cell | 3 studies | 25% ± 6% | |
myeloid cell | 3 studies | 20% ± 3% | |
ciliated cell | 3 studies | 22% ± 6% | |
retinal rod cell | 3 studies | 20% ± 3% | |
dendritic cell | 3 studies | 27% ± 9% | |
platelet | 3 studies | 18% ± 2% | |
T cell | 3 studies | 17% ± 2% | |
alveolar macrophage | 3 studies | 24% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2176.92 | 1445 / 1445 | 100% | 14.60 | 183 / 183 |
lung | 100% | 2430.05 | 578 / 578 | 100% | 15.58 | 1155 / 1155 |
pancreas | 100% | 1366.27 | 328 / 328 | 100% | 17.49 | 178 / 178 |
prostate | 100% | 2230.31 | 245 / 245 | 100% | 14.93 | 502 / 502 |
breast | 100% | 2540.87 | 459 / 459 | 100% | 18.04 | 1117 / 1118 |
bladder | 100% | 2635.86 | 21 / 21 | 100% | 15.84 | 503 / 504 |
ovary | 100% | 3086.38 | 180 / 180 | 100% | 11.19 | 429 / 430 |
thymus | 100% | 2453.94 | 653 / 653 | 100% | 19.28 | 603 / 605 |
stomach | 100% | 1592.19 | 359 / 359 | 100% | 13.45 | 285 / 286 |
intestine | 100% | 2408.82 | 966 / 966 | 100% | 15.64 | 525 / 527 |
uterus | 100% | 3049.39 | 170 / 170 | 100% | 20.17 | 457 / 459 |
kidney | 100% | 1582.53 | 89 / 89 | 99% | 14.75 | 894 / 901 |
skin | 100% | 2022.67 | 1809 / 1809 | 99% | 15.54 | 467 / 472 |
brain | 99% | 1096.51 | 2611 / 2642 | 100% | 18.00 | 705 / 705 |
adrenal gland | 100% | 2014.17 | 258 / 258 | 99% | 13.93 | 227 / 230 |
liver | 100% | 855.17 | 226 / 226 | 97% | 9.40 | 395 / 406 |
adipose | 100% | 2457.18 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2704.70 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 30.39 | 29 / 29 |
spleen | 100% | 2954.48 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 19.65 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 7.04 | 1 / 1 |
peripheral blood | 100% | 3540.71 | 928 / 929 | 0% | 0 | 0 / 0 |
muscle | 100% | 1692.89 | 801 / 803 | 0% | 0 | 0 / 0 |
heart | 98% | 1445.46 | 847 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 91% | 7.90 | 73 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0010212 | Biological process | response to ionizing radiation |
GO_0140861 | Biological process | DNA repair-dependent chromatin remodeling |
GO_0045739 | Biological process | positive regulation of DNA repair |
GO_0006302 | Biological process | double-strand break repair |
GO_0006282 | Biological process | regulation of DNA repair |
GO_0007095 | Biological process | mitotic G2 DNA damage checkpoint signaling |
GO_0044818 | Biological process | mitotic G2/M transition checkpoint |
GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
GO_0005654 | Cellular component | nucleoplasm |
GO_0070531 | Cellular component | BRCA1-A complex |
GO_0016604 | Cellular component | nuclear body |
GO_0035861 | Cellular component | site of double-strand break |
GO_0005634 | Cellular component | nucleus |
GO_0003677 | Molecular function | DNA binding |
GO_0070530 | Molecular function | K63-linked polyubiquitin modification-dependent protein binding |
GO_0042393 | Molecular function | histone binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0061649 | Molecular function | ubiquitin-modified histone reader activity |
GO_0005515 | Molecular function | protein binding |
Gene name | UIMC1 |
Protein name | Ubiquitin interaction motif containing 1 BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Ubiquitin interaction motif-containing protein 1) BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) |
Synonyms | RXRIP110 RAP80 |
Description | FUNCTION: Ubiquitin-binding protein . Specifically recognizes and binds 'Lys-63'-linked ubiquitin . Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. . |
Accessions | D6RDZ5 ENST00000506128.5 [Q96RL1-2] D6R9M3 ENST00000509236.5 ENST00000507513.1 D6RC40 D6RCQ3 ENST00000512031.5 ENST00000428382.2 ENST00000510698.2 [Q96RL1-4] ENST00000377227.8 [Q96RL1-1] Q96RL1 ENST00000511320.6 [Q96RL1-1] |