APLF report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006303Biological processdouble-strand break repair via nonhomologous end joining
GO_0006281Biological processDNA repair
GO_0000012Biological processsingle strand break repair
GO_0051106Biological processpositive regulation of DNA ligation
GO_0140861Biological processDNA repair-dependent chromatin remodeling
GO_0006302Biological processdouble-strand break repair
GO_0006974Biological processDNA damage response
GO_0045191Biological processregulation of isotype switching
GO_0006457Biological processprotein folding
GO_0071168Biological processprotein localization to chromatin
GO_0010717Biological processregulation of epithelial to mesenchymal transition
GO_0007566Biological processembryo implantation
GO_0005654Cellular componentnucleoplasm
GO_0090734Cellular componentsite of DNA damage
GO_0005829Cellular componentcytosol
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0042393Molecular functionhistone binding
GO_0003906Molecular functionDNA-(apurinic or apyrimidinic site) endonuclease activity
GO_0044183Molecular functionprotein folding chaperone
GO_0000166Molecular functionnucleotide binding
GO_0008408Molecular function3'-5' exonuclease activity
GO_0160002Molecular functionADP-D-ribose modification-dependent protein binding
GO_0140713Molecular functionhistone chaperone activity
GO_0046872Molecular functionmetal ion binding
GO_0004520Molecular functionDNA endonuclease activity
GO_0072572Molecular functionpoly-ADP-D-ribose binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAPLF
Protein nameAprataxin and PNKP like factor
Aprataxin and PNK-like factor (EC 3.1.-.-) (Apurinic-apyrimidinic endonuclease APLF) (PNK and APTX-like FHA domain-containing protein) (XRCC1-interacting protein 1)
SynonymsPALF
C2orf13
XIP1
DescriptionFUNCTION: Histone chaperone involved in single-strand and double-strand DNA break repair . Recruited to sites of DNA damage through interaction with branched poly-ADP-ribose chains, a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions . Following recruitment to DNA damage sites, acts as a histone chaperone that mediates histone eviction during DNA repair and promotes recruitment of histone variant MACROH2A1 . Also has a nuclease activity: displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro . Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage . Together with PARP3, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) . Also acts as a negative regulator of cell pluripotency by promoting histone exchange (By similarity). Required for the embryo implantation during the epithelial to mesenchymal transition in females (By similarity). .

AccessionsENST00000303795.9
F8WET0
ENST00000445692.5
Q8IW19
E9PRH6
ENST00000529851.5