RPA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0034502Biological processprotein localization to chromosome
GO_0006281Biological processDNA repair
GO_0006289Biological processnucleotide-excision repair
GO_0006974Biological processDNA damage response
GO_0006260Biological processDNA replication
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0051321Biological processmeiotic cell cycle
GO_0000723Biological processtelomere maintenance
GO_1990166Biological processprotein localization to site of double-strand break
GO_0006310Biological processDNA recombination
GO_0006284Biological processbase-excision repair
GO_0006298Biological processmismatch repair
GO_0007004Biological processtelomere maintenance via telomerase
GO_0006261Biological processDNA-templated DNA replication
GO_0005654Cellular componentnucleoplasm
GO_0090734Cellular componentsite of DNA damage
GO_0016605Cellular componentPML body
GO_0000781Cellular componentchromosome, telomeric region
GO_0005662Cellular componentDNA replication factor A complex
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0043047Molecular functionsingle-stranded telomeric DNA binding
GO_0140463Molecular functionchromatin-protein adaptor activity
GO_0046872Molecular functionmetal ion binding
GO_0098505Molecular functionG-rich strand telomeric DNA binding
GO_0005515Molecular functionprotein binding
GO_0003684Molecular functiondamaged DNA binding

IV. Literature review

[source]
Gene nameRPA1
Protein nameReplication protein A1
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Replication factor A protein 1
SynonymsREPA1
RPA70
DescriptionFUNCTION: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism . Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage . In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response . It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage . Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair . Also plays a role in base excision repair (BER) probably through interaction with UNG . Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. Plays a role in telomere maintenance . As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange . .

AccessionsENST00000571058.5
I3L2M5
I3L4R8
P27694
ENST00000254719.10
ENST00000574049.1
ENST00000570451.5
I3L524