Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 7 studies | 21% ± 5% | |
platelet | 6 studies | 22% ± 4% | |
epithelial cell | 5 studies | 27% ± 9% | |
fibroblast | 5 studies | 20% ± 5% | |
natural killer cell | 5 studies | 23% ± 6% | |
CD16-negative, CD56-bright natural killer cell, human | 4 studies | 18% ± 1% | |
lymphocyte | 4 studies | 19% ± 3% | |
glutamatergic neuron | 4 studies | 29% ± 11% | |
hematopoietic precursor cell | 3 studies | 21% ± 4% | |
CD16-positive, CD56-dim natural killer cell, human | 3 studies | 20% ± 2% | |
GABAergic neuron | 3 studies | 30% ± 8% | |
dendritic cell | 3 studies | 21% ± 4% | |
abnormal cell | 3 studies | 20% ± 3% | |
macrophage | 3 studies | 20% ± 1% | |
transit amplifying cell | 3 studies | 35% ± 12% | |
plasmacytoid dendritic cell | 3 studies | 22% ± 2% | |
erythroblast | 3 studies | 31% ± 15% | |
regulatory T cell | 3 studies | 18% ± 3% | |
astrocyte | 3 studies | 23% ± 4% | |
oligodendrocyte | 3 studies | 18% ± 2% | |
CD8-positive, alpha-beta T cell | 3 studies | 19% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 4501.02 | 1445 / 1445 | 100% | 62.87 | 183 / 183 |
ovary | 100% | 5318.60 | 180 / 180 | 100% | 50.22 | 430 / 430 |
stomach | 100% | 3117.59 | 359 / 359 | 100% | 45.54 | 286 / 286 |
prostate | 100% | 3927.07 | 245 / 245 | 100% | 59.46 | 501 / 502 |
brain | 100% | 2993.32 | 2633 / 2642 | 100% | 74.33 | 705 / 705 |
lung | 100% | 3277.93 | 576 / 578 | 100% | 63.60 | 1155 / 1155 |
intestine | 100% | 4490.79 | 966 / 966 | 100% | 47.46 | 525 / 527 |
skin | 100% | 5635.72 | 1809 / 1809 | 100% | 84.28 | 470 / 472 |
uterus | 100% | 4935.45 | 170 / 170 | 100% | 82.92 | 457 / 459 |
breast | 100% | 4601.57 | 459 / 459 | 100% | 70.65 | 1113 / 1118 |
thymus | 100% | 3978.23 | 653 / 653 | 99% | 66.10 | 600 / 605 |
bladder | 100% | 4941.33 | 21 / 21 | 99% | 54.99 | 498 / 504 |
kidney | 100% | 2394.58 | 89 / 89 | 97% | 46.09 | 870 / 901 |
pancreas | 97% | 1950.62 | 318 / 328 | 99% | 38.46 | 176 / 178 |
adrenal gland | 100% | 3839.09 | 258 / 258 | 93% | 36.54 | 215 / 230 |
liver | 96% | 1544.91 | 218 / 226 | 89% | 25.42 | 361 / 406 |
adipose | 100% | 4313.80 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 4836.53 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 109.80 | 29 / 29 |
muscle | 100% | 6319.07 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 4267.18 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 102.90 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 13.45 | 1 / 1 |
eye | 0% | 0 | 0 / 0 | 99% | 66.96 | 79 / 80 |
heart | 98% | 3238.17 | 846 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 89% | 3516.03 | 828 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006325 | Biological process | chromatin organization |
GO_0034502 | Biological process | protein localization to chromosome |
GO_0006281 | Biological process | DNA repair |
GO_0006289 | Biological process | nucleotide-excision repair |
GO_0006974 | Biological process | DNA damage response |
GO_0006260 | Biological process | DNA replication |
GO_0000724 | Biological process | double-strand break repair via homologous recombination |
GO_0051321 | Biological process | meiotic cell cycle |
GO_0000723 | Biological process | telomere maintenance |
GO_1990166 | Biological process | protein localization to site of double-strand break |
GO_0006310 | Biological process | DNA recombination |
GO_0006284 | Biological process | base-excision repair |
GO_0006298 | Biological process | mismatch repair |
GO_0007004 | Biological process | telomere maintenance via telomerase |
GO_0006261 | Biological process | DNA-templated DNA replication |
GO_0005654 | Cellular component | nucleoplasm |
GO_0090734 | Cellular component | site of DNA damage |
GO_0016605 | Cellular component | PML body |
GO_0000781 | Cellular component | chromosome, telomeric region |
GO_0005662 | Cellular component | DNA replication factor A complex |
GO_0035861 | Cellular component | site of double-strand break |
GO_0005634 | Cellular component | nucleus |
GO_0003697 | Molecular function | single-stranded DNA binding |
GO_0043047 | Molecular function | single-stranded telomeric DNA binding |
GO_0140463 | Molecular function | chromatin-protein adaptor activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0098505 | Molecular function | G-rich strand telomeric DNA binding |
GO_0005515 | Molecular function | protein binding |
GO_0003684 | Molecular function | damaged DNA binding |
Gene name | RPA1 |
Protein name | Replication protein A1 Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] Replication factor A protein 1 |
Synonyms | REPA1 RPA70 |
Description | FUNCTION: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism . Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage . In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response . It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage . Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair . Also plays a role in base excision repair (BER) probably through interaction with UNG . Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. Plays a role in telomere maintenance . As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange . . |
Accessions | ENST00000571058.5 I3L2M5 I3L4R8 P27694 ENST00000254719.10 ENST00000574049.1 ENST00000570451.5 I3L524 |