SHLD3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SHLD3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SHLD3 at tissue level.

III. Associated gene sets

GO_2000042Biological processnegative regulation of double-strand break repair via homologous recombination
GO_0006281Biological processDNA repair
GO_0002208Biological processsomatic diversification of immunoglobulins involved in immune response
GO_0045830Biological processpositive regulation of isotype switching
GO_2001034Biological processpositive regulation of double-strand break repair via nonhomologous end joining
GO_0043247Biological processtelomere maintenance in response to DNA damage
GO_0005730Cellular componentnucleolus
GO_0005694Cellular componentchromosome
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0035861Cellular componentsite of double-strand break
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSHLD3
Protein nameShieldin complex subunit 3 (REV7-interacting novel NHEJ regulator 1) (Shield complex subunit 3)
SynonymsFLJ26957
RINN1
DescriptionFUNCTION: Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres. .

AccessionsENST00000510585.3
Q6ZNX1