PRPF19 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006303Biological processdouble-strand break repair via nonhomologous end joining
GO_0000209Biological processprotein polyubiquitination
GO_0000244Biological processspliceosomal tri-snRNP complex assembly
GO_0010498Biological processproteasomal protein catabolic process
GO_0008610Biological processlipid biosynthetic process
GO_0048026Biological processpositive regulation of mRNA splicing, via spliceosome
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0008104Biological processprotein localization
GO_0000245Biological processspliceosomal complex assembly
GO_0000077Biological processDNA damage checkpoint signaling
GO_0005811Cellular componentlipid droplet
GO_0005681Cellular componentspliceosomal complex
GO_0016020Cellular componentmembrane
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0071007Cellular componentU2-type catalytic step 2 spliceosome
GO_0000974Cellular componentPrp19 complex
GO_0071006Cellular componentU2-type catalytic step 1 spliceosome
GO_0005737Cellular componentcytoplasm
GO_0071013Cellular componentcatalytic step 2 spliceosome
GO_0005662Cellular componentDNA replication factor A complex
GO_0035861Cellular componentsite of double-strand break
GO_0005819Cellular componentspindle
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0034450Molecular functionubiquitin-ubiquitin ligase activity
GO_0042802Molecular functionidentical protein binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePRPF19
Protein namePre-mRNA-processing factor 19 (EC 2.3.2.27)
Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (hPso4) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor)
SynonymsSNEV
PRP19
NMP200
DescriptionFUNCTION: Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome . Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex . Recruited to RNA polymerase II C-terminal domain (CTD) and the pre-mRNA, it may also couple the transcriptional and spliceosomal machineries . The XAB2 complex, which contains PRPF19, is also involved in pre-mRNA splicing, transcription and transcription-coupled repair . Beside its role in pre-mRNA splicing PRPF19, as part of the PRP19-CDC5L complex, plays a role in the DNA damage response/DDR. It is recruited to the sites of DNA damage by the RPA complex where PRPF19 directly ubiquitinates RPA1 and RPA2. 'Lys-63'-linked polyubiquitination of the RPA complex allows the recruitment of the ATR-ATRIP complex and the activation of ATR, a master regulator of the DNA damage response . May also play a role in DNA double-strand break (DSB) repair by recruiting the repair factor SETMAR to altered DNA . As part of the PSO4 complex may also be involved in the DNA interstrand cross-links/ICLs repair process . In addition, may also mediate 'Lys-48'-linked polyubiquitination of substrates and play a role in proteasomal degradation . May play a role in the biogenesis of lipid droplets (By similarity). May play a role in neural differentiation possibly through its function as part of the spliceosome (By similarity). .

FUNCTION: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. .

FUNCTION: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. .

FUNCTION: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. .

FUNCTION: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. .

AccessionsENST00000227524.9
F5GY56
ENST00000535326.1
H0YGF3
ENST00000546152.1
Q9UMS4
F5H2I0
H0YGZ5
ENST00000541371.5
ENST00000540473.5