MRE11 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032508Biological processDNA duplex unwinding
GO_0007062Biological processsister chromatid cohesion
GO_0006303Biological processdouble-strand break repair via nonhomologous end joining
GO_0006281Biological processDNA repair
GO_0008283Biological processcell population proliferation
GO_0007129Biological processhomologous chromosome pairing at meiosis
GO_0006302Biological processdouble-strand break repair
GO_2001033Biological processnegative regulation of double-strand break repair via nonhomologous end joining
GO_0007131Biological processreciprocal meiotic recombination
GO_0006974Biological processDNA damage response
GO_0110025Biological processDNA strand resection involved in replication fork processing
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0007095Biological processmitotic G2 DNA damage checkpoint signaling
GO_0033674Biological processpositive regulation of kinase activity
GO_0000729Biological processDNA double-strand break processing
GO_0044818Biological processmitotic G2/M transition checkpoint
GO_0043066Biological processnegative regulation of apoptotic process
GO_0035825Biological processhomologous recombination
GO_0032206Biological processpositive regulation of telomere maintenance
GO_0062176Biological processR-loop processing
GO_0000723Biological processtelomere maintenance
GO_0031954Biological processpositive regulation of protein autophosphorylation
GO_0031573Biological processmitotic intra-S DNA damage checkpoint signaling
GO_0006310Biological processDNA recombination
GO_0031860Biological processtelomeric 3' overhang formation
GO_0000019Biological processregulation of mitotic recombination
GO_0042138Biological processmeiotic DNA double-strand break formation
GO_0097552Biological processmitochondrial double-strand break repair via homologous recombination
GO_0007004Biological processtelomere maintenance via telomerase
GO_0030870Cellular componentMre11 complex
GO_0005657Cellular componentreplication fork
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0016605Cellular componentPML body
GO_0005737Cellular componentcytoplasm
GO_0070533Cellular componentBRCA1-C complex
GO_0000781Cellular componentchromosome, telomeric region
GO_0035861Cellular componentsite of double-strand break
GO_0098687Cellular componentchromosomal region
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0008296Molecular function3'-5'-DNA exonuclease activity
GO_0045296Molecular functioncadherin binding
GO_0042802Molecular functionidentical protein binding
GO_0008408Molecular function3'-5' exonuclease activity
GO_0030145Molecular functionmanganese ion binding
GO_0003678Molecular functionDNA helicase activity
GO_0004518Molecular functionnuclease activity
GO_0004520Molecular functionDNA endonuclease activity
GO_0000014Molecular functionsingle-stranded DNA endodeoxyribonuclease activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMRE11
Protein nameMRE11 homolog, double strand break repair nuclease
Double-strand break repair protein MRE11 (EC 3.1.-.-) (Double-strand break repair protein MRE11A) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A)
Double-strand break repair protein
MRE11 meiotic recombination 11 homolog A (S. cerevisiae) (MRE11 meiotic recombination 11-like protein A isoform 1) (MRE11A protein)
MRE11 meiotic recombination 11-like protein A isoform 2
Double-strand break repair protein MRE11
Alternative protein MRE11A
SynonymsMRE11A
HNGS1
DescriptionFUNCTION: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis . The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11 . RAD50 may be required to bind DNA ends and hold them in close proximity . This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point . The complex may also be required for DNA damage signaling via activation of the ATM kinase . In telomeres the MRN complex may modulate t-loop formation . .

FUNCTION: Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. .

AccessionsF5H742
ENST00000323929.8 [P49959-1]
F5GXT0
ENST00000407439.7 [P49959-3]
F5H256
ENST00000538923.1
Q9BS79
ENST00000540013.5
ENST00000536754.5
ENST00000393241.8
A0A0S2Z438
L8E9C6
Q05D78
P49959
ENST00000323977.7 [P49959-2]
F8W7U8