NABP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0006974Biological processDNA damage response
GO_0044818Biological processmitotic G2/M transition checkpoint
GO_0006281Biological processDNA repair
GO_0010212Biological processresponse to ionizing radiation
GO_0007093Biological processmitotic cell cycle checkpoint signaling
GO_0070876Cellular componentSOSS complex
GO_0000781Cellular componentchromosome, telomeric region
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0005515Molecular functionprotein binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameNABP1
Protein nameSOSS complex subunit B2 (Nucleic acid-binding protein 1) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2A) (Sensor of single-strand DNA complex subunit B2) (Sensor of ssDNA subunit B2) (SOSS-B2) (Single-stranded DNA-binding protein 2) (hSSB2)
SOSS complex subunit B2 (Nucleic acid-binding protein 1) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2A) (Sensor of single-strand DNA complex subunit B2) (Sensor of ssDNA subunit B2) (Single-stranded DNA-binding protein 2)
Nucleic acid binding protein 1
SynonymsSSB2
OBFC2A
DescriptionFUNCTION: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. .

AccessionsENST00000307849.7 [Q96AH0-3]
ENST00000409510.5 [Q96AH0-2]
Q96AH0
ENST00000674406.1 [Q96AH0-2]
ENST00000674414.1 [Q96AH0-1]
ENST00000307834.9
F8WAF5
ENST00000674172.1 [Q96AH0-1]
ENST00000674262.1 [Q96AH0-1]
H7C0W4
ENST00000674187.1 [Q96AH0-2]
ENST00000435931.1
ENST00000410026.7 [Q96AH0-2]
ENST00000425611.9 [Q96AH0-1]
ENST00000451500.5 [Q96AH0-3]
ENST00000674360.1 [Q96AH0-2]