Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 28 studies | 31% ± 10% | |
dendritic cell | 15 studies | 34% ± 12% | |
conventional dendritic cell | 15 studies | 24% ± 7% | |
monocyte | 14 studies | 29% ± 13% | |
classical monocyte | 14 studies | 25% ± 5% | |
regulatory T cell | 13 studies | 23% ± 4% | |
myeloid cell | 11 studies | 32% ± 18% | |
fibroblast | 10 studies | 24% ± 7% | |
T cell | 9 studies | 24% ± 8% | |
neutrophil | 9 studies | 38% ± 9% | |
CD4-positive, alpha-beta T cell | 9 studies | 20% ± 5% | |
mast cell | 8 studies | 24% ± 9% | |
B cell | 7 studies | 21% ± 6% | |
non-classical monocyte | 7 studies | 22% ± 2% | |
mononuclear phagocyte | 7 studies | 29% ± 7% | |
microglial cell | 7 studies | 27% ± 9% | |
leukocyte | 7 studies | 27% ± 12% | |
epithelial cell | 6 studies | 39% ± 20% | |
CD4-positive, alpha-beta memory T cell | 4 studies | 25% ± 4% | |
squamous epithelial cell | 4 studies | 33% ± 19% | |
innate lymphoid cell | 4 studies | 20% ± 3% | |
CD8-positive, alpha-beta T cell | 4 studies | 18% ± 3% | |
T follicular helper cell | 4 studies | 27% ± 12% | |
natural killer cell | 3 studies | 17% ± 2% | |
mature NK T cell | 3 studies | 20% ± 6% | |
enterocyte | 3 studies | 25% ± 6% | |
adipocyte | 3 studies | 28% ± 6% | |
mesothelial cell | 3 studies | 28% ± 8% | |
tissue-resident macrophage | 3 studies | 27% ± 4% | |
lymphocyte | 3 studies | 31% ± 10% | |
CD4-positive helper T cell | 3 studies | 21% ± 4% | |
basal cell | 3 studies | 21% ± 4% | |
CD8-positive, alpha-beta memory T cell | 3 studies | 19% ± 1% | |
T-helper 17 cell | 3 studies | 23% ± 4% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
lung | 5 studies | 24% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 100% | 7765.64 | 576 / 578 | 99% | 7.29 | 1146 / 1155 |
bladder | 100% | 2068.29 | 21 / 21 | 94% | 5.09 | 476 / 504 |
breast | 98% | 3010.47 | 450 / 459 | 89% | 3.34 | 996 / 1118 |
ovary | 88% | 1157.13 | 159 / 180 | 95% | 2.73 | 407 / 430 |
kidney | 87% | 2693.89 | 77 / 89 | 92% | 4.36 | 828 / 901 |
uterus | 82% | 1157.63 | 139 / 170 | 96% | 5.52 | 440 / 459 |
skin | 76% | 5831.90 | 1383 / 1809 | 94% | 3.99 | 443 / 472 |
esophagus | 66% | 1757.20 | 948 / 1445 | 100% | 6.26 | 183 / 183 |
intestine | 67% | 1996.51 | 650 / 966 | 95% | 3.67 | 502 / 527 |
stomach | 55% | 940.52 | 197 / 359 | 95% | 4.19 | 272 / 286 |
prostate | 73% | 1271.88 | 180 / 245 | 70% | 1.40 | 353 / 502 |
liver | 67% | 1326.91 | 152 / 226 | 65% | 1.66 | 265 / 406 |
pancreas | 29% | 371.21 | 95 / 328 | 92% | 4.63 | 164 / 178 |
thymus | 51% | 847.51 | 330 / 653 | 66% | 1.79 | 398 / 605 |
adrenal gland | 84% | 1439.65 | 216 / 258 | 22% | 0.61 | 51 / 230 |
adipose | 100% | 6006.00 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 9.86 | 29 / 29 |
spleen | 100% | 11202.34 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 5.77 | 1 / 1 |
peripheral blood | 98% | 8555.98 | 913 / 929 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 4.47 | 44 / 45 |
blood vessel | 73% | 1338.72 | 979 / 1335 | 0% | 0 | 0 / 0 |
brain | 2% | 29.21 | 65 / 2642 | 51% | 1.18 | 363 / 705 |
eye | 0% | 0 | 0 / 0 | 43% | 0.88 | 34 / 80 |
heart | 25% | 391.32 | 218 / 861 | 0% | 0 | 0 / 0 |
muscle | 15% | 191.20 | 117 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0000724 | Biological process | double-strand break repair via homologous recombination |
GO_0006974 | Biological process | DNA damage response |
GO_0044818 | Biological process | mitotic G2/M transition checkpoint |
GO_0006281 | Biological process | DNA repair |
GO_0010212 | Biological process | response to ionizing radiation |
GO_0007093 | Biological process | mitotic cell cycle checkpoint signaling |
GO_0070876 | Cellular component | SOSS complex |
GO_0000781 | Cellular component | chromosome, telomeric region |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0035861 | Cellular component | site of double-strand break |
GO_0005634 | Cellular component | nucleus |
GO_0003677 | Molecular function | DNA binding |
GO_0005515 | Molecular function | protein binding |
GO_0003697 | Molecular function | single-stranded DNA binding |
GO_0003723 | Molecular function | RNA binding |
Gene name | NABP1 |
Protein name | SOSS complex subunit B2 (Nucleic acid-binding protein 1) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2A) (Sensor of single-strand DNA complex subunit B2) (Sensor of ssDNA subunit B2) (SOSS-B2) (Single-stranded DNA-binding protein 2) (hSSB2) SOSS complex subunit B2 (Nucleic acid-binding protein 1) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2A) (Sensor of single-strand DNA complex subunit B2) (Sensor of ssDNA subunit B2) (Single-stranded DNA-binding protein 2) Nucleic acid binding protein 1 |
Synonyms | SSB2 OBFC2A |
Description | FUNCTION: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. . |
Accessions | ENST00000307849.7 [Q96AH0-3] ENST00000409510.5 [Q96AH0-2] Q96AH0 ENST00000674406.1 [Q96AH0-2] ENST00000674414.1 [Q96AH0-1] ENST00000307834.9 F8WAF5 ENST00000674172.1 [Q96AH0-1] ENST00000674262.1 [Q96AH0-1] H7C0W4 ENST00000674187.1 [Q96AH0-2] ENST00000435931.1 ENST00000410026.7 [Q96AH0-2] ENST00000425611.9 [Q96AH0-1] ENST00000451500.5 [Q96AH0-3] ENST00000674360.1 [Q96AH0-2] |