SETMAR report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SETMAR at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SETMAR at tissue level.

III. Associated gene sets

GO_2000373Biological processpositive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
GO_0006303Biological processdouble-strand break repair via nonhomologous end joining
GO_0090304Biological processnucleic acid metabolic process
GO_0008283Biological processcell population proliferation
GO_0032259Biological processmethylation
GO_0044774Biological processmitotic DNA integrity checkpoint signaling
GO_0015074Biological processDNA integration
GO_2001251Biological processnegative regulation of chromosome organization
GO_0006308Biological processDNA catabolic process
GO_0006338Biological processchromatin remodeling
GO_0000729Biological processDNA double-strand break processing
GO_0031297Biological processreplication fork processing
GO_2001034Biological processpositive regulation of double-strand break repair via nonhomologous end joining
GO_0005730Cellular componentnucleolus
GO_0000793Cellular componentcondensed chromosome
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0042800Molecular functionhistone H3K4 methyltransferase activity
GO_0004519Molecular functionendonuclease activity
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0140954Molecular functionhistone H3K36 dimethyltransferase activity
GO_0044547Molecular functionDNA topoisomerase binding
GO_0008270Molecular functionzinc ion binding
GO_0000014Molecular functionsingle-stranded DNA endodeoxyribonuclease activity
GO_0046975Molecular functionhistone H3K36 methyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSETMAR
Protein nameHistone-lysine N-methyltransferase SETMAR (SET domain and mariner transposase fusion protein) (Metnase) [Includes: Histone-lysine N-methyltransferase (EC 2.1.1.357); Transposon Hsmar1 transposase (EC 3.1.-.-)]
SETMAR protein
SET domain and mariner transposase fusion gene
Synonyms
DescriptionFUNCTION: Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity . In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining . Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A . .

AccessionsENST00000358950.4
ENST00000425863.5 [Q53H47-3]
B9ZVV8
Q96H41
ENST00000430981.1 [Q53H47-2]
ENST00000413809.5
ENST00000358065.5 [Q53H47-1]
F8WB33
Q53H47
ENST00000425046.1
F8WEU1