ARPC4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	29 studies	36% ± 14%	Explore
natural killer cell	29 studies	40% ± 16%	Explore
B cell	26 studies	34% ± 15%	Explore
classical monocyte	23 studies	41% ± 17%	Explore
CD8-positive, alpha-beta T cell	23 studies	31% ± 15%	Explore
T cell	21 studies	28% ± 11%	Explore
non-classical monocyte	20 studies	48% ± 22%	Explore
CD4-positive, alpha-beta T cell	20 studies	29% ± 11%	Explore
conventional dendritic cell	20 studies	46% ± 18%	Explore
endothelial cell	19 studies	29% ± 12%	Explore
monocyte	17 studies	41% ± 16%	Explore
dendritic cell	16 studies	49% ± 21%	Explore
fibroblast	15 studies	23% ± 10%	Explore
pericyte	15 studies	23% ± 7%	Explore
smooth muscle cell	14 studies	25% ± 9%	Explore
mature NK T cell	14 studies	31% ± 14%	Explore
regulatory T cell	14 studies	27% ± 8%	Explore
memory B cell	12 studies	25% ± 7%	Explore
plasmacytoid dendritic cell	12 studies	40% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	40% ± 17%	Explore
gamma-delta T cell	11 studies	34% ± 13%	Explore
myeloid cell	11 studies	40% ± 18%	Explore
naive B cell	10 studies	27% ± 8%	Explore
mast cell	9 studies	20% ± 6%	Explore
capillary endothelial cell	8 studies	20% ± 4%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	7 studies	25% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	7 studies	30% ± 14%	Explore
endothelial cell of lymphatic vessel	6 studies	24% ± 8%	Explore
platelet	6 studies	33% ± 9%	Explore
leukocyte	6 studies	37% ± 16%	Explore
mononuclear phagocyte	6 studies	42% ± 21%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	45% ± 14%	Explore
connective tissue cell	6 studies	24% ± 5%	Explore
megakaryocyte	6 studies	60% ± 21%	Explore
endothelial cell of artery	6 studies	27% ± 10%	Explore
goblet cell	6 studies	25% ± 9%	Explore
vein endothelial cell	6 studies	23% ± 8%	Explore
T follicular helper cell	6 studies	29% ± 9%	Explore
epithelial cell	6 studies	46% ± 19%	Explore
basal cell	6 studies	33% ± 18%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	23% ± 3%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	32% ± 15%	Explore
alveolar macrophage	5 studies	24% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	39% ± 15%	Explore
hematopoietic precursor cell	5 studies	46% ± 20%	Explore
plasmablast	5 studies	35% ± 20%	Explore
myofibroblast cell	5 studies	30% ± 6%	Explore
mucosal invariant T cell	5 studies	31% ± 10%	Explore
innate lymphoid cell	5 studies	27% ± 4%	Explore
plasma cell	5 studies	37% ± 11%	Explore
ciliated cell	5 studies	37% ± 8%	Explore
endothelial cell of vascular tree	5 studies	24% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	28% ± 16%	Explore
neutrophil	5 studies	30% ± 2%	Explore
progenitor cell	4 studies	37% ± 18%	Explore
microglial cell	4 studies	27% ± 13%	Explore
intermediate monocyte	4 studies	51% ± 27%	Explore
neuron	4 studies	26% ± 16%	Explore
enteroendocrine cell	4 studies	28% ± 11%	Explore
T-helper 17 cell	4 studies	28% ± 9%	Explore
pancreatic A cell	3 studies	44% ± 14%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	25% ± 1%	Explore
exhausted T cell	3 studies	41% ± 24%	Explore
glomerular endothelial cell	3 studies	21% ± 2%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	18% ± 1%	Explore
erythroblast	3 studies	30% ± 13%	Explore
hematopoietic stem cell	3 studies	23% ± 7%	Explore
lymphocyte	3 studies	43% ± 20%	Explore
precursor B cell	3 studies	29% ± 10%	Explore
pro-B cell	3 studies	28% ± 4%	Explore
intraepithelial lymphocyte	3 studies	28% ± 10%	Explore
germinal center B cell	3 studies	46% ± 17%	Explore
abnormal cell	3 studies	24% ± 7%	Explore
enterocyte	3 studies	18% ± 3%	Explore
group 3 innate lymphoid cell	3 studies	33% ± 14%	Explore
transit amplifying cell	3 studies	18% ± 2%	Explore
immature B cell	3 studies	35% ± 20%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	11 studies	32% ± 13%	Explore
peripheral blood	10 studies	44% ± 15%	Explore
intestine	10 studies	22% ± 9%	Explore
kidney	6 studies	19% ± 3%	Explore
bone marrow	4 studies	28% ± 12%	Explore
brain	4 studies	23% ± 8%	Explore
liver	4 studies	31% ± 11%	Explore
pancreas	3 studies	40% ± 9%	Explore
placenta	3 studies	21% ± 6%	Explore
uterus	3 studies	34% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	7250.67	258 / 258	100%	66.59	230 / 230
bladder	100%	6895.43	21 / 21	100%	131.39	504 / 504
esophagus	100%	7319.06	1445 / 1445	100%	52.45	183 / 183
intestine	100%	6947.04	966 / 966	100%	103.26	527 / 527
kidney	100%	7037.96	89 / 89	100%	72.02	901 / 901
liver	100%	3333.99	226 / 226	100%	60.11	406 / 406
lung	100%	7258.38	578 / 578	100%	81.80	1155 / 1155
ovary	100%	4936.13	180 / 180	100%	70.74	430 / 430
skin	100%	7603.16	1809 / 1809	100%	109.59	472 / 472
stomach	100%	5076.30	359 / 359	100%	80.28	286 / 286
thymus	100%	5988.59	653 / 653	100%	107.50	605 / 605
uterus	100%	6485.73	170 / 170	100%	112.92	459 / 459
breast	100%	6695.32	459 / 459	100%	99.64	1116 / 1118
brain	100%	5054.16	2637 / 2642	100%	86.92	705 / 705
prostate	100%	6458.83	245 / 245	100%	91.14	501 / 502
pancreas	97%	2818.22	319 / 328	99%	108.99	177 / 178
adipose	100%	7056.88	1204 / 1204	0%	0	0 / 0
blood vessel	100%	7968.90	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	67.12	80 / 80
lymph node	0%	0	0 / 0	100%	254.67	29 / 29
spleen	100%	10977.22	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	100.69	45 / 45
ureter	0%	0	0 / 0	100%	126.13	1 / 1
peripheral blood	100%	18584.35	928 / 929	0%	0	0 / 0
heart	99%	3597.66	854 / 861	0%	0	0 / 0
muscle	98%	3730.11	789 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0034314	Biological process	Arp2/3 complex-mediated actin nucleation
GO_0030041	Biological process	actin filament polymerization
GO_0045010	Biological process	actin nucleation
GO_0042995	Cellular component	cell projection
GO_0070062	Cellular component	extracellular exosome
GO_0005885	Cellular component	Arp2/3 protein complex
GO_0005829	Cellular component	cytosol
GO_0035861	Cellular component	site of double-strand break
GO_0005634	Cellular component	nucleus
GO_0019899	Molecular function	enzyme binding
GO_0005200	Molecular function	structural constituent of cytoskeleton
GO_0030674	Molecular function	protein-macromolecule adaptor activity
GO_0051015	Molecular function	actin filament binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ARPC4
Protein name	Actin related protein 2/3 complex subunit 4 Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC)
Synonyms	ARC20
Description	FUNCTION: Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) . The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility . In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA . The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) . .
Accessions	ENST00000433034.1 [P59998-3] ENST00000397261.8 [P59998-1] ENST00000498623.6 [P59998-4] R4GN08 ENST00000485273.1 ENST00000440787.5 ENST00000417500.5 P59998 F8WDW3 F8WDD7

ARPC4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review