DMC1 | OmnibusX

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DMC1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
uterus	99%	79.88	169 / 170	70%	3.11	322 / 459
esophagus	96%	42.94	1389 / 1445	51%	1.31	93 / 183
breast	98%	68.41	448 / 459	42%	0.99	468 / 1118
ovary	98%	55.52	177 / 180	39%	0.95	166 / 430
lung	89%	38.14	513 / 578	39%	0.90	447 / 1155
bladder	100%	54.05	21 / 21	24%	0.64	120 / 504
intestine	97%	44.20	935 / 966	25%	0.45	134 / 527
skin	96%	118.24	1728 / 1809	27%	0.69	126 / 472
blood vessel	99%	76.25	1322 / 1335	0%	0	0 / 0
brain	96%	48.19	2534 / 2642	3%	0.05	20 / 705
prostate	96%	52.88	234 / 245	2%	0.06	9 / 502
thymus	81%	23.54	528 / 653	16%	0.51	94 / 605
stomach	66%	24.99	238 / 359	29%	0.45	83 / 286
adipose	94%	57.72	1130 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	90%	2.48	26 / 29
tonsil	0%	0	0 / 0	84%	2.98	38 / 45
heart	82%	48.71	704 / 861	0%	0	0 / 0
muscle	80%	27.68	643 / 803	0%	0	0 / 0
kidney	63%	19.54	56 / 89	15%	0.25	133 / 901
spleen	68%	26.20	163 / 241	0%	0	0 / 0
adrenal gland	33%	7.32	86 / 258	13%	0.22	31 / 230
peripheral blood	35%	62.38	326 / 929	0%	0	0 / 0
pancreas	20%	3.80	66 / 328	13%	0.33	23 / 178
liver	9%	2.17	20 / 226	11%	0.25	44 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007283	Biological process	spermatogenesis
GO_0001541	Biological process	ovarian follicle development
GO_0007129	Biological process	homologous chromosome pairing at meiosis
GO_0007131	Biological process	reciprocal meiotic recombination
GO_0000730	Biological process	DNA recombinase assembly
GO_0007141	Biological process	male meiosis I
GO_0001556	Biological process	oocyte maturation
GO_0051321	Biological process	meiotic cell cycle
GO_1990918	Biological process	double-strand break repair involved in meiotic recombination
GO_0070192	Biological process	chromosome organization involved in meiotic cell cycle
GO_0006312	Biological process	mitotic recombination
GO_0042148	Biological process	DNA strand invasion
GO_0007286	Biological process	spermatid development
GO_0007292	Biological process	female gamete generation
GO_0000800	Cellular component	lateral element
GO_0005694	Cellular component	chromosome
GO_0000781	Cellular component	chromosome, telomeric region
GO_0000794	Cellular component	condensed nuclear chromosome
GO_0035861	Cellular component	site of double-strand break
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0003697	Molecular function	single-stranded DNA binding
GO_0140664	Molecular function	ATP-dependent DNA damage sensor activity
GO_0003690	Molecular function	double-stranded DNA binding
GO_0042802	Molecular function	identical protein binding
GO_0005524	Molecular function	ATP binding
GO_0000150	Molecular function	DNA strand exchange activity
GO_0008094	Molecular function	ATP-dependent activity, acting on DNA
GO_0005515	Molecular function	protein binding
GO_0016887	Molecular function	ATP hydrolysis activity

IV. Literature review

[source]

Gene name	DMC1
Protein name	Meiotic recombination protein DMC1/LIM15 homolog DNA meiotic recombinase 1 DMC1 protein
Synonyms	DMC1H LIM15
Description	FUNCTION: Participates in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. .
Accessions	ENST00000428462.6 [Q14565-2] ENST00000415483.1 Q14565 Q8IYL1 B0QYE0 ENST00000439567.5 B0QYE1 ENST00000216024.7 [Q14565-1]

DMC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review