RPA4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of RPA4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RPA4 at tissue level.

III. Associated gene sets

GO_0006289Biological processnucleotide-excision repair
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0006281Biological processDNA repair
GO_0006270Biological processDNA replication initiation
GO_0033260Biological processnuclear DNA replication
GO_0006260Biological processDNA replication
GO_0000077Biological processDNA damage checkpoint signaling
GO_0000781Cellular componentchromosome, telomeric region
GO_0005654Cellular componentnucleoplasm
GO_0005662Cellular componentDNA replication factor A complex
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0042162Molecular functiontelomeric DNA binding
GO_0005515Molecular functionprotein binding
GO_0003697Molecular functionsingle-stranded DNA binding

IV. Literature review

[source]
Gene nameRPA4
Protein nameReplication protein A 30 kDa subunit (RP-A p30) (Replication factor A protein 4) (RF-A protein 4)
Synonyms
DescriptionFUNCTION: As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange. .

AccessionsENST00000373040.4
Q13156