SAMHD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045087Biological processinnate immune response
GO_0051607Biological processdefense response to virus
GO_0006974Biological processDNA damage response
GO_0006203Biological processdGTP catabolic process
GO_0051289Biological processprotein homotetramerization
GO_0110025Biological processDNA strand resection involved in replication fork processing
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0045088Biological processregulation of innate immune response
GO_0006955Biological processimmune response
GO_0060339Biological processnegative regulation of type I interferon-mediated signaling pathway
GO_0016446Biological processsomatic hypermutation of immunoglobulin genes
GO_0009264Biological processdeoxyribonucleotide catabolic process
GO_0046061Biological processdATP catabolic process
GO_0005886Cellular componentplasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0097197Cellular componenttetraspanin-enriched microdomain
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0003676Molecular functionnucleic acid binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0008832Molecular functiondGTPase activity
GO_0106375Molecular functiondeoxynucleoside triphosphate hydrolase activity
GO_0042802Molecular functionidentical protein binding
GO_0016793Molecular functiontriphosphoric monoester hydrolase activity
GO_0005525Molecular functionGTP binding
GO_0008270Molecular functionzinc ion binding
GO_0032567Molecular functiondGTP binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0004540Molecular functionRNA nuclease activity

IV. Literature review

[source]
Gene nameSAMHD1
Protein nameDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5) (SAM domain and HD domain-containing protein 1) (hSAMHD1)
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
SynonymsMOP5
DescriptionFUNCTION: Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks . Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses, such as HIV-1: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells . Likewise, suppresses LINE-1 retrotransposon activity . Not able to restrict infection by HIV-2 virus; because restriction activity is counteracted by HIV-2 viral protein Vpx . In addition to virus restriction, dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools . Phosphorylation at Thr-592 acts as a switch to control dNTPase-dependent and -independent functions: it inhibits dNTPase activity and ability to restrict infection by viruses, while it promotes DNA end resection at stalled replication forks . Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication . Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation . Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity . Enhances immunoglobulin hypermutation in B-lymphocytes by promoting transversion mutation (By similarity). .

AccessionsA0A2R8YCS7
ENST00000646673.2 [Q9Y3Z3-1]
A0A2R8Y7R5
A0A2R8YG48
A0A2R8YF18
ENST00000646066.1 [Q9Y3Z3-3]
ENST00000646904.1
ENST00000642246.1
ENST00000647163.1
A0A2R8Y755
ENST00000644250.2 [Q9Y3Z3-4]
A0A2R8YFV6
ENST00000645033.1
A0A2R8Y5D2
A0A2R8YF51
ENST00000262878.5 [Q9Y3Z3-4]
ENST00000643078.1
ENST00000642616.1
ENST00000645444.2
A0A2R8YDI8
A0A2R8YD90
ENST00000683720.1
ENST00000643825.1
ENST00000644250
A0A2R8Y586
ENST00000646869.1 [Q9Y3Z3-1]
A0A804HL67
ENST00000646866.1
ENST00000642186.1
ENST00000646121.1
ENST00000683766.1 [Q9Y3Z3-1]
ENST00000643918.1
ENST00000644114.2
ENST00000465985.2
Q9Y3Z3
ENST00000682773.1 [Q9Y3Z3-1]