ARPC3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	48 studies	71% ± 23%	Explore
macrophage	47 studies	69% ± 26%	Explore
natural killer cell	41 studies	68% ± 19%	Explore
endothelial cell	38 studies	51% ± 21%	Explore
fibroblast	36 studies	43% ± 16%	Explore
CD8-positive, alpha-beta T cell	35 studies	65% ± 19%	Explore
T cell	34 studies	61% ± 20%	Explore
CD4-positive, alpha-beta T cell	32 studies	65% ± 20%	Explore
conventional dendritic cell	31 studies	85% ± 19%	Explore
pericyte	30 studies	47% ± 18%	Explore
dendritic cell	28 studies	69% ± 25%	Explore
classical monocyte	28 studies	84% ± 14%	Explore
plasmacytoid dendritic cell	28 studies	83% ± 16%	Explore
monocyte	26 studies	72% ± 23%	Explore
regulatory T cell	26 studies	71% ± 16%	Explore
smooth muscle cell	25 studies	41% ± 14%	Explore
non-classical monocyte	25 studies	89% ± 17%	Explore
mast cell	23 studies	60% ± 23%	Explore
plasma cell	22 studies	56% ± 23%	Explore
mature NK T cell	22 studies	61% ± 20%	Explore
epithelial cell	21 studies	67% ± 17%	Explore
memory B cell	20 studies	82% ± 11%	Explore
naive B cell	20 studies	75% ± 17%	Explore
basal cell	20 studies	54% ± 22%	Explore
gamma-delta T cell	19 studies	67% ± 17%	Explore
endothelial cell of lymphatic vessel	18 studies	59% ± 18%	Explore
connective tissue cell	18 studies	46% ± 18%	Explore
myeloid cell	18 studies	65% ± 28%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	56% ± 17%	Explore
mucosal invariant T cell	16 studies	61% ± 18%	Explore
ciliated cell	16 studies	63% ± 19%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	73% ± 15%	Explore
neutrophil	15 studies	64% ± 19%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	68% ± 19%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	70% ± 13%	Explore
myofibroblast cell	13 studies	47% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	61% ± 21%	Explore
innate lymphoid cell	12 studies	64% ± 19%	Explore
plasmablast	12 studies	72% ± 19%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	65% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	68% ± 18%	Explore
secretory cell	12 studies	64% ± 16%	Explore
capillary endothelial cell	12 studies	52% ± 15%	Explore
endothelial cell of artery	12 studies	54% ± 18%	Explore
goblet cell	11 studies	53% ± 22%	Explore
vein endothelial cell	11 studies	54% ± 15%	Explore
endothelial cell of vascular tree	11 studies	48% ± 12%	Explore
microglial cell	11 studies	52% ± 24%	Explore
type I pneumocyte	10 studies	43% ± 18%	Explore
progenitor cell	10 studies	64% ± 17%	Explore
abnormal cell	10 studies	63% ± 19%	Explore
mesothelial cell	10 studies	52% ± 16%	Explore
type II pneumocyte	9 studies	48% ± 19%	Explore
T follicular helper cell	9 studies	59% ± 15%	Explore
alveolar macrophage	8 studies	67% ± 30%	Explore
club cell	8 studies	62% ± 19%	Explore
platelet	8 studies	54% ± 19%	Explore
leukocyte	8 studies	75% ± 11%	Explore
mononuclear phagocyte	8 studies	66% ± 28%	Explore
hematopoietic stem cell	8 studies	78% ± 20%	Explore
erythrocyte	8 studies	52% ± 18%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	76% ± 21%	Explore
epithelial cell of proximal tubule	7 studies	48% ± 12%	Explore
neuron	7 studies	51% ± 23%	Explore
enterocyte	7 studies	50% ± 11%	Explore
IgA plasma cell	7 studies	31% ± 21%	Explore
IgG plasma cell	7 studies	32% ± 21%	Explore
precursor B cell	7 studies	75% ± 25%	Explore
hematopoietic precursor cell	6 studies	70% ± 23%	Explore
ionocyte	6 studies	65% ± 14%	Explore
respiratory goblet cell	6 studies	59% ± 21%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	77% ± 25%	Explore
kidney loop of Henle epithelial cell	6 studies	44% ± 7%	Explore
renal alpha-intercalated cell	6 studies	59% ± 6%	Explore
immature B cell	6 studies	86% ± 13%	Explore
intermediate monocyte	6 studies	84% ± 18%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	74% ± 15%	Explore
oligodendrocyte precursor cell	6 studies	26% ± 9%	Explore
CD4-positive helper T cell	5 studies	53% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	67% ± 13%	Explore
duct epithelial cell	5 studies	58% ± 20%	Explore
exhausted T cell	5 studies	82% ± 8%	Explore
megakaryocyte	5 studies	76% ± 9%	Explore
brush cell	5 studies	41% ± 24%	Explore
T-helper 17 cell	5 studies	74% ± 18%	Explore
group 3 innate lymphoid cell	5 studies	76% ± 11%	Explore
astrocyte	5 studies	27% ± 12%	Explore
double negative thymocyte	5 studies	84% ± 5%	Explore
granulocyte	5 studies	73% ± 18%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	63% ± 30%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	67% ± 15%	Explore
deuterosomal cell	4 studies	46% ± 14%	Explore
squamous epithelial cell	4 studies	53% ± 27%	Explore
glomerular endothelial cell	4 studies	45% ± 11%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	57% ± 14%	Explore
enteroendocrine cell	4 studies	70% ± 12%	Explore
intestinal crypt stem cell	4 studies	51% ± 15%	Explore
transit amplifying cell	4 studies	51% ± 16%	Explore
retinal ganglion cell	4 studies	51% ± 27%	Explore
erythroblast	4 studies	62% ± 17%	Explore
lymphocyte	4 studies	61% ± 28%	Explore
pro-B cell	4 studies	80% ± 7%	Explore
adventitial cell	4 studies	39% ± 5%	Explore
mucus secreting cell	4 studies	61% ± 18%	Explore
inflammatory macrophage	4 studies	60% ± 15%	Explore
oligodendrocyte	4 studies	20% ± 2%	Explore
germinal center B cell	4 studies	84% ± 10%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	64% ± 11%	Explore
glutamatergic neuron	4 studies	36% ± 19%	Explore
hepatocyte	4 studies	47% ± 25%	Explore
T-helper 1 cell	4 studies	76% ± 14%	Explore
precursor cell	3 studies	73% ± 10%	Explore
pancreatic A cell	3 studies	71% ± 19%	Explore
type B pancreatic cell	3 studies	60% ± 21%	Explore
monocyte-derived dendritic cell	3 studies	88% ± 15%	Explore
podocyte	3 studies	55% ± 12%	Explore
neural crest cell	3 studies	41% ± 1%	Explore
thymocyte	3 studies	51% ± 29%	Explore
extravillous trophoblast	3 studies	91% ± 5%	Explore
placental villous trophoblast	3 studies	93% ± 2%	Explore
neuroendocrine cell	3 studies	73% ± 19%	Explore
retina horizontal cell	3 studies	34% ± 18%	Explore
retinal cone cell	3 studies	29% ± 11%	Explore
serous secreting cell	3 studies	59% ± 1%	Explore
tissue-resident macrophage	3 studies	68% ± 23%	Explore
follicular B cell	3 studies	67% ± 14%	Explore
intraepithelial lymphocyte	3 studies	77% ± 10%	Explore
Mueller cell	3 studies	34% ± 7%	Explore
acinar cell	3 studies	37% ± 8%	Explore
muscle cell	3 studies	30% ± 12%	Explore
myoepithelial cell	3 studies	45% ± 21%	Explore
luminal cell of prostate epithelium	3 studies	39% ± 9%	Explore
IgM plasma cell	3 studies	58% ± 19%	Explore
GABAergic neuron	3 studies	29% ± 10%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	90% ± 10%	Explore
glial cell	3 studies	51% ± 21%	Explore
keratinocyte	3 studies	43% ± 9%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	78% ± 5%	Explore
double-positive, alpha-beta thymocyte	3 studies	84% ± 7%	Explore
progenitor cell of mammary luminal epithelium	3 studies	55% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	74% ± 14%	Explore
lung	19 studies	60% ± 17%	Explore
intestine	13 studies	46% ± 16%	Explore
kidney	9 studies	56% ± 17%	Explore
brain	9 studies	41% ± 19%	Explore
eye	7 studies	26% ± 11%	Explore
lymph node	6 studies	68% ± 21%	Explore
liver	6 studies	58% ± 20%	Explore
bone marrow	5 studies	56% ± 20%	Explore
uterus	5 studies	58% ± 25%	Explore
pancreas	4 studies	57% ± 23%	Explore
placenta	4 studies	77% ± 19%	Explore
prostate	4 studies	41% ± 8%	Explore
breast	4 studies	54% ± 8%	Explore
heart	3 studies	27% ± 11%	Explore
adipose	3 studies	38% ± 21%	Explore
adrenal gland	3 studies	60% ± 16%	Explore
esophagus	3 studies	59% ± 26%	Explore
skin	3 studies	35% ± 12%	Explore
thymus	3 studies	72% ± 25%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	8126.40	258 / 258	100%	131.44	230 / 230
esophagus	100%	8614.60	1445 / 1445	100%	140.71	183 / 183
kidney	100%	8060.52	89 / 89	100%	145.46	901 / 901
lung	100%	9918.06	578 / 578	100%	182.62	1155 / 1155
ovary	100%	4342.32	180 / 180	100%	148.70	430 / 430
uterus	100%	5392.91	170 / 170	100%	208.13	459 / 459
skin	100%	8292.51	1808 / 1809	100%	131.38	472 / 472
thymus	100%	6150.53	653 / 653	100%	170.11	604 / 605
prostate	100%	6362.71	245 / 245	100%	154.94	501 / 502
bladder	100%	7031.38	21 / 21	100%	221.26	502 / 504
liver	100%	4120.00	225 / 226	100%	112.73	406 / 406
breast	100%	7486.18	459 / 459	100%	187.31	1113 / 1118
brain	100%	5433.39	2630 / 2642	100%	119.85	705 / 705
stomach	100%	6210.84	359 / 359	99%	160.74	284 / 286
intestine	100%	7746.78	966 / 966	99%	178.23	522 / 527
pancreas	99%	4076.97	325 / 328	99%	181.85	177 / 178
adipose	100%	8023.42	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	395.96	29 / 29
spleen	100%	15149.56	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	179.78	45 / 45
ureter	0%	0	0 / 0	100%	235.03	1 / 1
peripheral blood	100%	19297.57	927 / 929	0%	0	0 / 0
blood vessel	100%	7456.94	1331 / 1335	0%	0	0 / 0
heart	96%	3596.02	830 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	96%	93.84	77 / 80
muscle	88%	2500.91	709 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0034314	Biological process	Arp2/3 complex-mediated actin nucleation
GO_1990090	Biological process	cellular response to nerve growth factor stimulus
GO_0030833	Biological process	regulation of actin filament polymerization
GO_0070358	Biological process	actin polymerization-dependent cell motility
GO_0061850	Cellular component	growth cone leading edge
GO_0015629	Cellular component	actin cytoskeleton
GO_0070062	Cellular component	extracellular exosome
GO_0005885	Cellular component	Arp2/3 protein complex
GO_0005829	Cellular component	cytosol
GO_0030027	Cellular component	lamellipodium
GO_0031941	Cellular component	filamentous actin
GO_0035861	Cellular component	site of double-strand break
GO_0005925	Cellular component	focal adhesion
GO_0016020	Cellular component	membrane
GO_0005634	Cellular component	nucleus
GO_0005200	Molecular function	structural constituent of cytoskeleton
GO_0051015	Molecular function	actin filament binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ARPC3
Protein name	Actin-related protein 2/3 complex subunit 3 Actin related protein 2/3 complex subunit 3 Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC)
Synonyms	ARC21
Description	FUNCTION: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) . The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility . In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA . The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) . . FUNCTION: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. .
Accessions	F8VR50 ENST00000547365.1 ENST00000228825.12 ENST00000426440.5 Q2LE71 C9JZD1 O15145

ARPC3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review