XRCC4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051103Biological processDNA ligation involved in DNA repair
GO_0006303Biological processdouble-strand break repair via nonhomologous end joining
GO_0010165Biological processresponse to X-ray
GO_0051351Biological processpositive regulation of ligase activity
GO_0006302Biological processdouble-strand break repair
GO_0033152Biological processimmunoglobulin V(D)J recombination
GO_1990166Biological processprotein localization to site of double-strand break
GO_0071285Biological processcellular response to lithium ion
GO_0032807Cellular componentDNA ligase IV complex
GO_0005654Cellular componentnucleoplasm
GO_0005958Cellular componentDNA-dependent protein kinase-DNA ligase 4 complex
GO_0005829Cellular componentcytosol
GO_0000793Cellular componentcondensed chromosome
GO_0035861Cellular componentsite of double-strand break
GO_0070419Cellular componentnonhomologous end joining complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0016874Molecular functionligase activity
GO_0070975Molecular functionFHA domain binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameXRCC4
Protein nameDNA repair protein XRCC4 (hXRCC4) (X-ray repair cross-complementing protein 4) [Cleaved into: Protein XRCC4, C-terminus (XRCC4/C)]
Synonyms
DescriptionFUNCTION: [DNA repair protein XRCC4]: DNA non-homologous end joining (NHEJ) core factor, required for double-strand break repair and V(D)J recombination . Acts as a scaffold protein that regulates recruitment of other proteins to DNA double-strand breaks (DSBs) . Associates with NHEJ1/XLF to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired . The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other . The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors . Plays a key role in the NHEJ ligation step of the broken DNA during DSB repair via direct interaction with DNA ligase IV (LIG4): the LIG4-XRCC4 subcomplex reseals the DNA breaks after the gap filling is completed . XRCC4 stabilizes LIG4, regulates its subcellular localization and enhances LIG4's joining activity . Binding of the LIG4-XRCC4 subcomplex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends . Promotes displacement of PNKP from processed strand break termini . .; FUNCTION: [Protein XRCC4, C-terminus]: Acts as an activator of the phospholipid scramblase activity of XKR4 . This form, which is generated upon caspase-3 (CASP3) cleavage, translocates into the cytoplasm and interacts with XKR4, thereby promoting phosphatidylserine scramblase activity of XKR4 and leading to phosphatidylserine exposure on apoptotic cell surface . .

AccessionsENST00000282268.7 [Q13426-2]
ENST00000396027.9 [Q13426-2]
ENST00000511817.1 [Q13426-1]
ENST00000338635.10 [Q13426-1]
Q13426