Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 12 studies | 23% ± 6% | |
adipocyte | 9 studies | 29% ± 6% | |
fibroblast | 9 studies | 24% ± 6% | |
oligodendrocyte | 8 studies | 21% ± 7% | |
astrocyte | 7 studies | 27% ± 10% | |
epithelial cell | 6 studies | 34% ± 11% | |
macrophage | 6 studies | 27% ± 5% | |
glutamatergic neuron | 5 studies | 46% ± 20% | |
dendritic cell | 5 studies | 20% ± 3% | |
endothelial cell of lymphatic vessel | 5 studies | 22% ± 4% | |
GABAergic neuron | 5 studies | 41% ± 18% | |
oligodendrocyte precursor cell | 5 studies | 24% ± 8% | |
mast cell | 4 studies | 19% ± 2% | |
myeloid cell | 4 studies | 26% ± 8% | |
type I pneumocyte | 4 studies | 26% ± 9% | |
cardiac muscle cell | 3 studies | 20% ± 2% | |
ciliated cell | 3 studies | 21% ± 3% | |
retinal rod cell | 3 studies | 18% ± 1% | |
connective tissue cell | 3 studies | 19% ± 1% | |
club cell | 3 studies | 27% ± 9% | |
respiratory goblet cell | 3 studies | 31% ± 9% | |
T cell | 3 studies | 19% ± 2% | |
alveolar macrophage | 3 studies | 30% ± 11% | |
monocyte | 3 studies | 28% ± 6% | |
smooth muscle cell | 3 studies | 18% ± 1% | |
type II pneumocyte | 3 studies | 22% ± 4% | |
lymphocyte | 3 studies | 23% ± 4% | |
basal cell | 3 studies | 31% ± 13% | |
goblet cell | 3 studies | 39% ± 28% | |
transit amplifying cell | 3 studies | 31% ± 18% | |
interneuron | 3 studies | 43% ± 22% | |
neuron | 3 studies | 41% ± 17% | |
microglial cell | 3 studies | 21% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 2117.38 | 459 / 459 | 100% | 32.94 | 1118 / 1118 |
esophagus | 100% | 1463.57 | 1445 / 1445 | 100% | 24.53 | 183 / 183 |
lung | 100% | 1643.18 | 578 / 578 | 100% | 19.29 | 1154 / 1155 |
bladder | 100% | 1511.29 | 21 / 21 | 100% | 17.65 | 503 / 504 |
prostate | 100% | 2050.45 | 245 / 245 | 100% | 33.65 | 501 / 502 |
liver | 100% | 1972.43 | 226 / 226 | 100% | 20.74 | 405 / 406 |
ovary | 100% | 1583.20 | 180 / 180 | 99% | 18.10 | 427 / 430 |
thymus | 100% | 2499.47 | 653 / 653 | 99% | 17.67 | 600 / 605 |
pancreas | 100% | 953.41 | 328 / 328 | 99% | 17.31 | 176 / 178 |
intestine | 100% | 1736.74 | 966 / 966 | 99% | 20.62 | 521 / 527 |
uterus | 100% | 1569.36 | 170 / 170 | 99% | 16.93 | 453 / 459 |
kidney | 100% | 2211.73 | 89 / 89 | 99% | 25.91 | 889 / 901 |
stomach | 100% | 1193.90 | 359 / 359 | 99% | 20.71 | 282 / 286 |
brain | 98% | 714.71 | 2602 / 2642 | 100% | 17.76 | 705 / 705 |
adrenal gland | 100% | 2640.98 | 258 / 258 | 97% | 15.82 | 223 / 230 |
skin | 100% | 1698.99 | 1809 / 1809 | 92% | 15.97 | 432 / 472 |
adipose | 100% | 2030.95 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1482.16 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 20.05 | 29 / 29 |
spleen | 100% | 1652.20 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 15.37 | 1 / 1 |
muscle | 99% | 852.27 | 797 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 17.47 | 44 / 45 |
heart | 96% | 836.76 | 824 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 73% | 10.31 | 58 / 80 |
peripheral blood | 59% | 724.15 | 545 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0010569 | Biological process | regulation of double-strand break repair via homologous recombination |
GO_2000042 | Biological process | negative regulation of double-strand break repair via homologous recombination |
GO_0006281 | Biological process | DNA repair |
GO_0002208 | Biological process | somatic diversification of immunoglobulins involved in immune response |
GO_0045830 | Biological process | positive regulation of isotype switching |
GO_2001034 | Biological process | positive regulation of double-strand break repair via nonhomologous end joining |
GO_0043247 | Biological process | telomere maintenance in response to DNA damage |
GO_0015629 | Cellular component | actin cytoskeleton |
GO_0005694 | Cellular component | chromosome |
GO_0005654 | Cellular component | nucleoplasm |
GO_0000785 | Cellular component | chromatin |
GO_0035861 | Cellular component | site of double-strand break |
GO_0005634 | Cellular component | nucleus |
GO_0005515 | Molecular function | protein binding |
Gene name | SHLD2 |
Protein name | Shieldin complex subunit 2 Shieldin complex subunit 2 (Protein FAM35A) (RINN1-REV7-interacting novel NHEJ regulator 2) (Shield complex subunit 2) |
Synonyms | FAM35A RINN2 |
Description | FUNCTION: Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) . During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection . Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres . . |
Accessions | U3KQ89 ENST00000298786.5 [Q86V20-2] ENST00000298784.5 [Q86V20-1] Q86V20 ENST00000437629.6 |