SHLD2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010569Biological processregulation of double-strand break repair via homologous recombination
GO_2000042Biological processnegative regulation of double-strand break repair via homologous recombination
GO_0006281Biological processDNA repair
GO_0002208Biological processsomatic diversification of immunoglobulins involved in immune response
GO_0045830Biological processpositive regulation of isotype switching
GO_2001034Biological processpositive regulation of double-strand break repair via nonhomologous end joining
GO_0043247Biological processtelomere maintenance in response to DNA damage
GO_0015629Cellular componentactin cytoskeleton
GO_0005694Cellular componentchromosome
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSHLD2
Protein nameShieldin complex subunit 2
Shieldin complex subunit 2 (Protein FAM35A) (RINN1-REV7-interacting novel NHEJ regulator 2) (Shield complex subunit 2)
SynonymsFAM35A
RINN2
DescriptionFUNCTION: Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) . During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection . Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres . .

AccessionsU3KQ89
ENST00000298786.5 [Q86V20-2]
ENST00000298784.5 [Q86V20-1]
Q86V20
ENST00000437629.6