ARPC2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	50 studies	62% ± 22%	Explore
macrophage	50 studies	67% ± 24%	Explore
natural killer cell	48 studies	74% ± 21%	Explore
endothelial cell	46 studies	51% ± 20%	Explore
T cell	41 studies	63% ± 22%	Explore
fibroblast	41 studies	45% ± 18%	Explore
CD8-positive, alpha-beta T cell	41 studies	68% ± 21%	Explore
pericyte	35 studies	52% ± 21%	Explore
CD4-positive, alpha-beta T cell	35 studies	66% ± 21%	Explore
dendritic cell	31 studies	73% ± 22%	Explore
smooth muscle cell	30 studies	49% ± 20%	Explore
conventional dendritic cell	30 studies	86% ± 15%	Explore
classical monocyte	29 studies	78% ± 16%	Explore
regulatory T cell	28 studies	74% ± 18%	Explore
monocyte	27 studies	71% ± 21%	Explore
plasmacytoid dendritic cell	26 studies	79% ± 16%	Explore
plasma cell	25 studies	53% ± 21%	Explore
non-classical monocyte	25 studies	90% ± 10%	Explore
epithelial cell	25 studies	60% ± 23%	Explore
endothelial cell of lymphatic vessel	24 studies	55% ± 20%	Explore
mast cell	23 studies	51% ± 22%	Explore
mature NK T cell	23 studies	71% ± 19%	Explore
basal cell	23 studies	65% ± 20%	Explore
gamma-delta T cell	20 studies	74% ± 19%	Explore
memory B cell	20 studies	76% ± 9%	Explore
naive B cell	20 studies	63% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	19 studies	57% ± 16%	Explore
myeloid cell	19 studies	68% ± 24%	Explore
connective tissue cell	18 studies	56% ± 19%	Explore
CD16-negative, CD56-bright natural killer cell, human	17 studies	69% ± 19%	Explore
mucosal invariant T cell	17 studies	65% ± 17%	Explore
ciliated cell	17 studies	45% ± 20%	Explore
neutrophil	17 studies	58% ± 18%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	83% ± 15%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	70% ± 17%	Explore
capillary endothelial cell	15 studies	46% ± 17%	Explore
myofibroblast cell	15 studies	50% ± 18%	Explore
endothelial cell of artery	14 studies	54% ± 19%	Explore
microglial cell	14 studies	45% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	67% ± 21%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	71% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	76% ± 15%	Explore
vein endothelial cell	13 studies	52% ± 17%	Explore
endothelial cell of vascular tree	13 studies	53% ± 14%	Explore
type II pneumocyte	12 studies	52% ± 25%	Explore
innate lymphoid cell	12 studies	66% ± 18%	Explore
plasmablast	12 studies	73% ± 14%	Explore
mesothelial cell	12 studies	53% ± 24%	Explore
type I pneumocyte	11 studies	46% ± 15%	Explore
platelet	11 studies	51% ± 21%	Explore
secretory cell	11 studies	65% ± 17%	Explore
leukocyte	11 studies	69% ± 18%	Explore
goblet cell	11 studies	46% ± 18%	Explore
T follicular helper cell	10 studies	71% ± 14%	Explore
club cell	10 studies	44% ± 21%	Explore
abnormal cell	10 studies	50% ± 15%	Explore
progenitor cell	9 studies	60% ± 15%	Explore
neuron	9 studies	47% ± 20%	Explore
IgG plasma cell	9 studies	40% ± 17%	Explore
hematopoietic stem cell	9 studies	67% ± 22%	Explore
astrocyte	9 studies	27% ± 11%	Explore
alveolar macrophage	8 studies	71% ± 22%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	82% ± 15%	Explore
mononuclear phagocyte	8 studies	69% ± 26%	Explore
enterocyte	8 studies	45% ± 17%	Explore
IgA plasma cell	8 studies	40% ± 14%	Explore
glutamatergic neuron	8 studies	40% ± 21%	Explore
respiratory goblet cell	7 studies	48% ± 19%	Explore
erythrocyte	7 studies	39% ± 20%	Explore
oligodendrocyte precursor cell	7 studies	32% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	69% ± 18%	Explore
hematopoietic precursor cell	6 studies	72% ± 23%	Explore
ionocyte	6 studies	45% ± 8%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	82% ± 18%	Explore
epithelial cell of proximal tubule	6 studies	31% ± 8%	Explore
kidney loop of Henle epithelial cell	6 studies	32% ± 5%	Explore
renal alpha-intercalated cell	6 studies	42% ± 16%	Explore
megakaryocyte	6 studies	75% ± 21%	Explore
transit amplifying cell	6 studies	49% ± 20%	Explore
lymphocyte	6 studies	61% ± 22%	Explore
precursor B cell	6 studies	75% ± 10%	Explore
immature B cell	6 studies	80% ± 9%	Explore
intermediate monocyte	6 studies	81% ± 21%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	79% ± 10%	Explore
granulocyte	6 studies	66% ± 14%	Explore
CD4-positive helper T cell	5 studies	62% ± 13%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	70% ± 11%	Explore
exhausted T cell	5 studies	86% ± 8%	Explore
enteroendocrine cell	5 studies	60% ± 20%	Explore
erythroblast	5 studies	46% ± 22%	Explore
brush cell	5 studies	37% ± 22%	Explore
T-helper 17 cell	5 studies	83% ± 12%	Explore
group 3 innate lymphoid cell	5 studies	77% ± 11%	Explore
mucus secreting cell	5 studies	25% ± 4%	Explore
double negative thymocyte	5 studies	87% ± 4%	Explore
GABAergic neuron	5 studies	37% ± 16%	Explore
interneuron	5 studies	34% ± 17%	Explore
oligodendrocyte	5 studies	25% ± 5%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	68% ± 26%	Explore
deuterosomal cell	4 studies	38% ± 7%	Explore
squamous epithelial cell	4 studies	54% ± 15%	Explore
pancreatic A cell	4 studies	71% ± 19%	Explore
type B pancreatic cell	4 studies	58% ± 23%	Explore
glomerular endothelial cell	4 studies	46% ± 12%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	45% ± 13%	Explore
retinal ganglion cell	4 studies	79% ± 22%	Explore
pro-B cell	4 studies	72% ± 8%	Explore
amacrine cell	4 studies	37% ± 18%	Explore
adventitial cell	4 studies	44% ± 7%	Explore
adipocyte	4 studies	20% ± 3%	Explore
inflammatory macrophage	4 studies	67% ± 13%	Explore
muscle cell	4 studies	36% ± 16%	Explore
germinal center B cell	4 studies	88% ± 7%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	49% ± 7%	Explore
glial cell	4 studies	41% ± 23%	Explore
melanocyte	4 studies	43% ± 23%	Explore
keratinocyte	4 studies	66% ± 23%	Explore
T-helper 1 cell	4 studies	85% ± 8%	Explore
duct epithelial cell	3 studies	39% ± 7%	Explore
hillock cell	3 studies	59% ± 24%	Explore
precursor cell	3 studies	72% ± 11%	Explore
pancreatic D cell	3 studies	68% ± 27%	Explore
monocyte-derived dendritic cell	3 studies	85% ± 18%	Explore
podocyte	3 studies	54% ± 12%	Explore
intestinal crypt stem cell	3 studies	47% ± 12%	Explore
neural crest cell	3 studies	47% ± 10%	Explore
retinal bipolar neuron	3 studies	40% ± 16%	Explore
renal principal cell	3 studies	43% ± 6%	Explore
thymocyte	3 studies	64% ± 19%	Explore
extravillous trophoblast	3 studies	95% ± 2%	Explore
placental villous trophoblast	3 studies	97% ± 2%	Explore
common myeloid progenitor	3 studies	61% ± 30%	Explore
neuroendocrine cell	3 studies	61% ± 22%	Explore
retina horizontal cell	3 studies	38% ± 18%	Explore
retinal cone cell	3 studies	46% ± 18%	Explore
retinal pigment epithelial cell	3 studies	37% ± 20%	Explore
retinal rod cell	3 studies	33% ± 12%	Explore
serous secreting cell	3 studies	35% ± 22%	Explore
tissue-resident macrophage	3 studies	73% ± 17%	Explore
intraepithelial lymphocyte	3 studies	84% ± 2%	Explore
Mueller cell	3 studies	26% ± 4%	Explore
endothelial cell of sinusoid	3 studies	27% ± 6%	Explore
myoepithelial cell	3 studies	64% ± 6%	Explore
luminal cell of prostate epithelium	3 studies	38% ± 10%	Explore
IgM plasma cell	3 studies	58% ± 18%	Explore
pancreatic ductal cell	3 studies	82% ± 10%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	93% ± 2%	Explore
hepatocyte	3 studies	44% ± 17%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	75% ± 2%	Explore
double-positive, alpha-beta thymocyte	3 studies	83% ± 3%	Explore
progenitor cell of mammary luminal epithelium	3 studies	42% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	21 studies	58% ± 19%	Explore
peripheral blood	21 studies	73% ± 13%	Explore
intestine	14 studies	46% ± 20%	Explore
brain	14 studies	36% ± 17%	Explore
kidney	9 studies	49% ± 21%	Explore
eye	9 studies	32% ± 13%	Explore
bone marrow	7 studies	54% ± 26%	Explore
lymph node	6 studies	69% ± 11%	Explore
liver	6 studies	54% ± 18%	Explore
pancreas	5 studies	58% ± 24%	Explore
placenta	5 studies	69% ± 31%	Explore
uterus	5 studies	60% ± 25%	Explore
adipose	5 studies	31% ± 19%	Explore
heart	4 studies	30% ± 10%	Explore
prostate	4 studies	56% ± 22%	Explore
breast	4 studies	56% ± 6%	Explore
adrenal gland	3 studies	56% ± 16%	Explore
esophagus	3 studies	63% ± 26%	Explore
skin	3 studies	56% ± 16%	Explore
thymus	3 studies	65% ± 31%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	16371.71	21 / 21	100%	173.43	504 / 504
esophagus	100%	18548.24	1445 / 1445	100%	150.35	183 / 183
intestine	100%	14612.67	966 / 966	100%	152.07	527 / 527
lung	100%	19418.12	578 / 578	100%	166.38	1155 / 1155
ovary	100%	9131.48	180 / 180	100%	144.67	430 / 430
stomach	100%	11475.03	359 / 359	100%	142.79	286 / 286
uterus	100%	10315.59	170 / 170	100%	176.75	459 / 459
breast	100%	13079.13	459 / 459	100%	132.32	1115 / 1118
prostate	100%	10186.88	245 / 245	100%	79.68	500 / 502
skin	100%	20653.34	1809 / 1809	100%	146.28	470 / 472
thymus	100%	8765.97	652 / 653	100%	108.08	602 / 605
kidney	100%	9687.97	89 / 89	98%	96.04	883 / 901
brain	98%	7220.41	2582 / 2642	100%	98.39	705 / 705
adrenal gland	100%	8540.80	258 / 258	92%	66.04	211 / 230
pancreas	88%	4080.36	290 / 328	99%	170.21	177 / 178
liver	82%	3872.11	185 / 226	98%	59.31	397 / 406
adipose	100%	15889.24	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	364.42	29 / 29
spleen	100%	21715.76	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	220.74	45 / 45
ureter	0%	0	0 / 0	100%	62.10	1 / 1
peripheral blood	100%	36420.65	928 / 929	0%	0	0 / 0
blood vessel	100%	17106.85	1332 / 1335	0%	0	0 / 0
muscle	100%	11718.51	800 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	98%	78.80	78 / 80
heart	96%	7338.12	828 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0030838	Biological process	positive regulation of actin filament polymerization
GO_0070358	Biological process	actin polymerization-dependent cell motility
GO_0010592	Biological process	positive regulation of lamellipodium assembly
GO_0030041	Biological process	actin filament polymerization
GO_0034314	Biological process	Arp2/3 complex-mediated actin nucleation
GO_1900026	Biological process	positive regulation of substrate adhesion-dependent cell spreading
GO_0098978	Cellular component	glutamatergic synapse
GO_0005885	Cellular component	Arp2/3 protein complex
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0036195	Cellular component	muscle cell projection membrane
GO_0043005	Cellular component	neuron projection
GO_0005925	Cellular component	focal adhesion
GO_0015629	Cellular component	actin cytoskeleton
GO_0005829	Cellular component	cytosol
GO_0005768	Cellular component	endosome
GO_0030027	Cellular component	lamellipodium
GO_0035861	Cellular component	site of double-strand break
GO_0005634	Cellular component	nucleus
GO_0005200	Molecular function	structural constituent of cytoskeleton
GO_0051015	Molecular function	actin filament binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ARPC2
Protein name	Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC) Actin related protein 2/3 complex subunit 2 (Actin related protein 2/3 complex, subunit 2, 34kDa, isoform CRA_e) Arp2/3 complex 34 kDa subunit Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit)
Synonyms	ARC34 hCG_16304 PRO2446
Description	FUNCTION: Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) . The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility . Seems to contact the mother actin filament . In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA . The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) . . FUNCTION: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. . FUNCTION: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. .
Accessions	ENST00000456575.1 G5E9S7 ENST00000414983.5 H7C3F9 C9JTV5 ENST00000420201.5 ENST00000420104.5 O15144 G5E9J0 Q53R19 ENST00000295685.14 ENST00000315717.10

ARPC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review