ATF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007254Biological processJNK cascade
GO_0002244Biological processhematopoietic progenitor cell differentiation
GO_0003151Biological processoutflow tract morphogenesis
GO_0110024Biological processpositive regulation of cardiac muscle myoblast proliferation
GO_1990253Biological processcellular response to leucine starvation
GO_0060052Biological processneurofilament cytoskeleton organization
GO_0001701Biological processin utero embryonic development
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0010628Biological processpositive regulation of gene expression
GO_0006974Biological processDNA damage response
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_0003419Biological processgrowth plate cartilage chondrocyte proliferation
GO_0014070Biological processresponse to organic cyclic compound
GO_0001889Biological processliver development
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0001865Biological processNK T cell differentiation
GO_0006970Biological processresponse to osmotic stress
GO_0072740Biological processcellular response to anisomycin
GO_0007033Biological processvacuole organization
GO_0016525Biological processnegative regulation of angiogenesis
GO_0044255Biological processcellular lipid metabolic process
GO_0030509Biological processBMP signaling pathway
GO_1990144Biological processintrinsic apoptotic signaling pathway in response to hypoxia
GO_0098586Biological processcellular response to virus
GO_1902110Biological processpositive regulation of mitochondrial membrane permeability involved in apoptotic process
GO_0034599Biological processcellular response to oxidative stress
GO_0003418Biological processgrowth plate cartilage chondrocyte differentiation
GO_0021754Biological processfacial nucleus development
GO_0097284Biological processhepatocyte apoptotic process
GO_0003360Biological processbrainstem development
GO_0006606Biological processprotein import into nucleus
GO_0006355Biological processregulation of DNA-templated transcription
GO_0021743Biological processhypoglossal nucleus development
GO_0042789Biological processmRNA transcription by RNA polymerase II
GO_0060612Biological processadipose tissue development
GO_0097049Biological processmotor neuron apoptotic process
GO_1902742Biological processapoptotic process involved in development
GO_0021742Biological processabducens nucleus development
GO_0031573Biological processmitotic intra-S DNA damage checkpoint signaling
GO_0032915Biological processpositive regulation of transforming growth factor beta2 production
GO_0060245Biological processdetection of cell density
GO_0038066Biological processp38MAPK cascade
GO_0045815Biological processtranscription initiation-coupled chromatin remodeling
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0050872Biological processwhite fat cell differentiation
GO_0005654Cellular componentnucleoplasm
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_1902562Cellular componentH4 histone acetyltransferase complex
GO_0005737Cellular componentcytoplasm
GO_0005741Cellular componentmitochondrial outer membrane
GO_0000785Cellular componentchromatin
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000987Molecular functioncis-regulatory region sequence-specific DNA binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0043522Molecular functionleucine zipper domain binding
GO_0019901Molecular functionprotein kinase binding
GO_0042802Molecular functionidentical protein binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0010485Molecular functionhistone H4 acetyltransferase activity
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0046872Molecular functionmetal ion binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0004402Molecular functionhistone acetyltransferase activity
GO_0035497Molecular functioncAMP response element binding
GO_0044013Molecular functionhistone H2B acetyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0008140Molecular functioncAMP response element binding protein binding

IV. Literature review

[source]
Gene nameATF2
Protein nameActivating transcription factor 2 splice variant ATF2-var12
Activating transcription factor 2 splice variant ATF2-var0 (Activating transcription factor 2 splice variant ATF2-var3) (Activating transcription factor 2 splice variant ATF2-var7)
Activating transcription factor 2 splice variant ATF2-var10 (Activating transcription factor 2 splice variant ATF2-var4)
Activating transcription factor 2
Cyclic AMP-dependent transcription factor ATF-2
Activating transcription factor 2 splice variant ATF2-var6 (Activating transcription factor 2 splice variant ATF2-var9)
Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1)
SynonymsCREBP1
CREB2
DescriptionFUNCTION: Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro . In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. .

FUNCTION: Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). .

FUNCTION: Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). .

AccessionsENST00000415955.5
ENST00000264110.7 [P15336-1]
B8ZZU6
ENST00000417080.5
ENST00000409437.5
F2Z2K2
ENST00000392544.5 [P15336-1]
ENST00000409635.5 [P15336-4]
ENST00000345739.9 [P15336-4]
E9PBF9
E9PEK8
ENST00000409833.5 [P15336-3]
ENST00000435004.6
A4D7U9
ENST00000428760.5
A4D7V5
A4D7U3
ENST00000421438.5
ENST00000409499.5 [P15336-8]
ENST00000426833.7 [P15336-5]
ENST00000456655.5
A4D7U7
H7C2N6
ENST00000429579.5
C9JCI8
ENST00000435231.6
P15336
ENST00000437522.5