HELB | OmnibusX

Name	Number of supported studies	Average coverage
CD4-positive, alpha-beta T cell	9 studies	22% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	17% ± 1%	Explore
T cell	5 studies	25% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	21% ± 4%	Explore
CD8-positive, alpha-beta T cell	5 studies	17% ± 2%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	22% ± 4%	Explore
lymphocyte	4 studies	26% ± 8%	Explore
regulatory T cell	4 studies	17% ± 1%	Explore
natural killer cell	3 studies	21% ± 2%	Explore
T follicular helper cell	3 studies	21% ± 3%	Explore
gamma-delta T cell	3 studies	18% ± 4%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of HELB at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	96%	315.20	1392 / 1445	99%	5.26	182 / 183
lung	100%	738.29	577 / 578	85%	2.43	985 / 1155
stomach	99%	406.34	357 / 359	85%	3.19	243 / 286
breast	100%	522.31	458 / 459	83%	2.57	928 / 1118
intestine	100%	542.13	964 / 966	77%	2.05	404 / 527
skin	99%	350.41	1788 / 1809	71%	1.68	335 / 472
uterus	100%	426.38	170 / 170	65%	1.34	298 / 459
ovary	100%	517.44	180 / 180	63%	1.46	273 / 430
pancreas	100%	328.64	328 / 328	60%	1.12	106 / 178
prostate	100%	568.48	245 / 245	54%	1.08	272 / 502
bladder	100%	388.24	21 / 21	54%	1.28	272 / 504
kidney	100%	400.89	89 / 89	49%	1.01	445 / 901
thymus	100%	530.99	652 / 653	40%	0.65	244 / 605
liver	100%	415.51	226 / 226	13%	0.21	52 / 406
adrenal gland	96%	221.55	247 / 258	13%	0.18	30 / 230
adipose	100%	476.43	1204 / 1204	0%	0	0 / 0
spleen	100%	1171.46	241 / 241	0%	0	0 / 0
peripheral blood	98%	950.72	913 / 929	0%	0	0 / 0
blood vessel	89%	234.37	1187 / 1335	0%	0	0 / 0
brain	66%	133.30	1737 / 2642	14%	0.26	97 / 705
heart	79%	169.33	677 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	64%	2.11	29 / 45
lymph node	0%	0	0 / 0	59%	2.67	17 / 29
muscle	40%	72.54	318 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	9%	0.10	7 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0032508	Biological process	DNA duplex unwinding
GO_0006281	Biological process	DNA repair
GO_0006269	Biological process	DNA replication, synthesis of primer
GO_0006974	Biological process	DNA damage response
GO_0006260	Biological process	DNA replication
GO_1903775	Biological process	regulation of DNA double-strand break processing
GO_2000042	Biological process	negative regulation of double-strand break repair via homologous recombination
GO_0005739	Cellular component	mitochondrion
GO_0005654	Cellular component	nucleoplasm
GO_0016604	Cellular component	nuclear body
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005662	Cellular component	DNA replication factor A complex
GO_0035861	Cellular component	site of double-strand break
GO_0005634	Cellular component	nucleus
GO_0044877	Molecular function	protein-containing complex binding
GO_0017116	Molecular function	single-stranded DNA helicase activity
GO_0043139	Molecular function	5'-3' DNA helicase activity
GO_0005524	Molecular function	ATP binding
GO_0016887	Molecular function	ATP hydrolysis activity

Gene name	HELB
Protein name	DNA helicase B DNA helicase B (hDHB) (EC 3.6.4.12)
Synonyms
Description	FUNCTION: 5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection . Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB . As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation . Acts independently of TP53BP1 . Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates . During S phase, may facilitate cellular recovery from replication stress . .
Accessions	ENST00000440906.6 [Q8NG08-2] F5H1I4 ENST00000247815.9 [Q8NG08-1] ENST00000545134.1 [Q8NG08-1] ENST00000542394.5 Q8NG08

HELB report