SHLD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000042Biological processnegative regulation of double-strand break repair via homologous recombination
GO_0006281Biological processDNA repair
GO_0002208Biological processsomatic diversification of immunoglobulins involved in immune response
GO_0045830Biological processpositive regulation of isotype switching
GO_2001034Biological processpositive regulation of double-strand break repair via nonhomologous end joining
GO_0043247Biological processtelomere maintenance in response to DNA damage
GO_0005694Cellular componentchromosome
GO_0000785Cellular componentchromatin
GO_0035861Cellular componentsite of double-strand break
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSHLD1
Protein nameShieldin complex subunit 1
Alternative protein C20orf196
Shieldin complex subunit 1 (RINN1-REV7-interacting novel NHEJ regulator 3) (Shield complex subunit 1)
SynonymsRINN3
C20orf196
DescriptionFUNCTION: Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres. .

AccessionsA0A0A0MSQ5
ENST00000303142.11 [Q8IYI0-1]
L8EBE3
Q5TGA6
Q5TGB0
ENST00000378979.8
ENST00000445603.1
ENST00000442185.1
Q8IYI0