WRAP53 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of WRAP53 at tissue level.

III. Associated gene sets

GO_0090671Biological processtelomerase RNA localization to Cajal body
GO_0006281Biological processDNA repair
GO_0045739Biological processpositive regulation of DNA repair
GO_0030576Biological processCajal body organization
GO_0032203Biological processtelomere formation via telomerase
GO_1904851Biological processpositive regulation of establishment of protein localization to telomere
GO_0090666Biological processscaRNA localization to Cajal body
GO_1904867Biological processprotein localization to Cajal body
GO_0051973Biological processpositive regulation of telomerase activity
GO_1905168Biological processpositive regulation of double-strand break repair via homologous recombination
GO_0034337Biological processRNA folding
GO_2000781Biological processpositive regulation of double-strand break repair
GO_2001034Biological processpositive regulation of double-strand break repair via nonhomologous end joining
GO_0007004Biological processtelomere maintenance via telomerase
GO_0005654Cellular componentnucleoplasm
GO_0005697Cellular componenttelomerase holoenzyme complex
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0015030Cellular componentCajal body
GO_0000781Cellular componentchromosome, telomeric region
GO_0035861Cellular componentsite of double-strand break
GO_0042393Molecular functionhistone binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0042802Molecular functionidentical protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0070034Molecular functiontelomerase RNA binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameWRAP53
Protein nameTelomerase Cajal body protein 1 (WD repeat-containing protein 79)
Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta)
WD repeat containing antisense to TP53
SynonymsWDR79
TCAB1
DescriptionFUNCTION: RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies . Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) . Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes . In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex . Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity . In addition, also controls telomerase holoenzyme complex localization to Cajal body . During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity . In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies . Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks . Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) . .

AccessionsENST00000698744.1
A0A8V8TNM2
ENST00000463804.6
A0A8V8TM74
E9PMG4
ENST00000698746.1
ENST00000498311.5
ENST00000396463.7
K7EJ50
ENST00000534050.5
Q9BUR4
A0A8V8TNY4
ENST00000698743.1
ENST00000698742.1
E9PMR3
A0A8V8TMM9
A0A8V8TM47
ENST00000698747.1
ENST00000316024.9
ENST00000431639.6
A0A8V8TM44
ENST00000457584.6
ENST00000698745.1