NHEJ1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NHEJ1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NHEJ1 at tissue level.

III. Associated gene sets

GO_0051103Biological processDNA ligation involved in DNA repair
GO_0030217Biological processT cell differentiation
GO_0006303Biological processdouble-strand break repair via nonhomologous end joining
GO_0007417Biological processcentral nervous system development
GO_0033152Biological processimmunoglobulin V(D)J recombination
GO_0051351Biological processpositive regulation of ligase activity
GO_0010212Biological processresponse to ionizing radiation
GO_0030183Biological processB cell differentiation
GO_0005958Cellular componentDNA-dependent protein kinase-DNA ligase 4 complex
GO_0070419Cellular componentnonhomologous end joining complex
GO_0032807Cellular componentDNA ligase IV complex
GO_0005654Cellular componentnucleoplasm
GO_0035861Cellular componentsite of double-strand break
GO_0001650Cellular componentfibrillar center
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0070182Molecular functionDNA polymerase binding
GO_0045027Molecular functionDNA end binding

IV. Literature review

[source]
Gene nameNHEJ1
Protein nameNon-homologous end joining factor 1
Non-homologous end-joining factor 1
HCG2043685, isoform CRA_b (Non-homologous end joining factor 1)
Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor)
SynonymsXLF
hCG_2043685
DescriptionFUNCTION: DNA repair protein involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination . Plays a key role in NHEJ by promoting the ligation of various mismatched and non-cohesive ends . Together with PAXX, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends . May act in concert with XRCC5-XRCC6 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are non-complementary or partially complementary . In some studies, has been shown to associate with XRCC4 to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired . Alternatively, it has also been shown that rather than forming filaments, a single NHEJ1 dimer interacts through both head domains with XRCC4 to promote the close alignment of DNA ends (By similarity). The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other . The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors . Binds DNA in a length-dependent manner . .

AccessionsA0A8V8TMZ4
ENST00000418099.5
ENST00000698202.1 [Q9H9Q4-1]
H7C0G7
G5E9Q8
F8WEB8
ENST00000409720.5 [Q9H9Q4-2]
ENST00000356853.10 [Q9H9Q4-1]
ENST00000457600.2
ENST00000698175.1
ENST00000426304.6
Q9H9Q4
C9JWV4
ENST00000450447.1
ENST00000457600.3 [Q9H9Q4-1]
ENST00000698174.1 [Q9H9Q4-1]
ENST00000698203.1 [Q9H9Q4-1]