UFL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032434Biological processregulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0006281Biological processDNA repair
GO_0002841Biological processnegative regulation of T cell mediated immune response to tumor cell
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0060252Biological processpositive regulation of glial cell proliferation
GO_0001649Biological processosteoblast differentiation
GO_0033146Biological processregulation of intracellular estrogen receptor signaling pathway
GO_1903895Biological processnegative regulation of IRE1-mediated unfolded protein response
GO_0140501Biological processpositive regulation of reticulophagy
GO_0006974Biological processDNA damage response
GO_0032880Biological processregulation of protein localization
GO_0050868Biological processnegative regulation of T cell activation
GO_1990592Biological processprotein K69-linked ufmylation
GO_0050727Biological processregulation of inflammatory response
GO_0072344Biological processrescue of stalled ribosome
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0032790Biological processribosome disassembly
GO_0071569Biological processprotein ufmylation
GO_0060218Biological processhematopoietic stem cell differentiation
GO_0030218Biological processerythrocyte differentiation
GO_0031397Biological processnegative regulation of protein ubiquitination
GO_0043066Biological processnegative regulation of apoptotic process
GO_0010508Biological processpositive regulation of autophagy
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0061709Biological processreticulophagy
GO_0043122Biological processregulation of canonical NF-kappaB signal transduction
GO_1902065Biological processresponse to L-glutamate
GO_0000077Biological processDNA damage checkpoint signaling
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0032991Cellular componentprotein-containing complex
GO_0043005Cellular componentneuron projection
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005741Cellular componentmitochondrial outer membrane
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0019901Molecular functionprotein kinase binding
GO_0061666Molecular functionUFM1 ligase activity
GO_0071568Molecular functionUFM1 transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUFL1
Protein nameE3 UFM1-protein ligase 1 (EC 2.3.2.-) (E3 UFM1-protein transferase 1) (Multiple alpha-helix protein located at ER) (Novel LZAP-binding protein) (Regulator of C53/LZAP and DDRGK1)
SynonymsKIAA0776
NLBP
MAXER
RCAD
DescriptionFUNCTION: E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to lysine residues on target proteins, and which plays a key role in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress . In response to endoplasmic reticulum stress, recruited to the endoplasmic reticulum membrane by DDRGK1, and mediates ufmylation of proteins such as RPN1 and RPL26/uL24, thereby promoting reticulophagy of endoplasmic reticulum sheets . Ufmylation-dependent reticulophagy inhibits the unfolded protein response (UPR) via ERN1/IRE1-alpha . Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis, blood vessel morphogenesis or inflammatory response . Regulates inflammation in response to endoplasmic reticulum stress by promoting reticulophagy, leading to inhibit the activity of the NF-kappa-B transcription factor (By similarity). Mediates ufmylation of DDRGK1 and CDK5RAP3; the role of these modifications is however unclear: as both DDRGK1 and CDK5RAP3 act as substrate adapters for ufmylation, it is uncertain whether ufmylation of these proteins is a collateral effect or is required for ufmylation . Catalyzes ufmylation of various subunits of the ribosomal complex or associated components, such as RPS3/uS3, RPS20/uS10, RPL10/uL16, RPL26/uL24 and EIF6 (By similarity). Anchors CDK5RAP3 in the cytoplasm, preventing its translocation to the nucleus which allows expression of the CCND1 cyclin and progression of cells through the G1/S transition . Also involved in the response to DNA damage: recruited to double-strand break sites following DNA damage and mediates monoufmylation of histone H4 . Catalyzes ufmylation of TRIP4, thereby playing a role in nuclear receptor-mediated transcription . Required for hematopoietic stem cell function and hematopoiesis (By similarity). Required for cardiac homeostasis (By similarity). .

AccessionsENST00000369278.5 [O94874-1]
O94874