Name | Number of supported studies | Average coverage | |
---|---|---|---|
fibroblast | 10 studies | 23% ± 7% | |
oligodendrocyte | 10 studies | 28% ± 12% | |
plasmacytoid dendritic cell | 8 studies | 22% ± 5% | |
ciliated cell | 8 studies | 25% ± 11% | |
endothelial cell | 7 studies | 29% ± 5% | |
pericyte | 7 studies | 18% ± 3% | |
astrocyte | 7 studies | 31% ± 10% | |
epithelial cell | 6 studies | 38% ± 18% | |
retinal rod cell | 6 studies | 23% ± 4% | |
macrophage | 6 studies | 21% ± 5% | |
oligodendrocyte precursor cell | 5 studies | 27% ± 9% | |
natural killer cell | 5 studies | 16% ± 1% | |
plasma cell | 4 studies | 28% ± 13% | |
CD16-negative, CD56-bright natural killer cell, human | 4 studies | 18% ± 3% | |
naive thymus-derived CD8-positive, alpha-beta T cell | 4 studies | 17% ± 3% | |
microglial cell | 4 studies | 20% ± 4% | |
basal cell | 4 studies | 32% ± 7% | |
GABAergic neuron | 4 studies | 32% ± 10% | |
connective tissue cell | 4 studies | 20% ± 5% | |
goblet cell | 4 studies | 28% ± 12% | |
plasmablast | 3 studies | 47% ± 16% | |
CD4-positive, alpha-beta T cell | 3 studies | 18% ± 2% | |
non-classical monocyte | 3 studies | 19% ± 5% | |
naive B cell | 3 studies | 16% ± 1% | |
B cell | 3 studies | 16% ± 1% | |
club cell | 3 studies | 19% ± 1% | |
retina horizontal cell | 3 studies | 19% ± 2% | |
retinal cone cell | 3 studies | 30% ± 3% | |
rod bipolar cell | 3 studies | 27% ± 4% | |
abnormal cell | 3 studies | 20% ± 4% | |
type I pneumocyte | 3 studies | 17% ± 1% | |
glutamatergic neuron | 3 studies | 44% ± 5% | |
dendritic cell | 3 studies | 30% ± 11% | |
smooth muscle cell | 3 studies | 17% ± 2% | |
myofibroblast cell | 3 studies | 20% ± 3% | |
adipocyte | 3 studies | 23% ± 6% | |
regulatory T cell | 3 studies | 16% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2401.29 | 1445 / 1445 | 100% | 39.99 | 183 / 183 |
ovary | 100% | 2787.37 | 180 / 180 | 100% | 24.97 | 430 / 430 |
lung | 100% | 2043.00 | 576 / 578 | 100% | 32.46 | 1155 / 1155 |
adrenal gland | 100% | 3022.80 | 258 / 258 | 100% | 29.78 | 229 / 230 |
brain | 100% | 1636.49 | 2636 / 2642 | 100% | 32.63 | 703 / 705 |
breast | 100% | 2353.57 | 459 / 459 | 99% | 42.92 | 1112 / 1118 |
prostate | 100% | 1973.93 | 245 / 245 | 99% | 42.08 | 499 / 502 |
thymus | 100% | 2517.59 | 653 / 653 | 99% | 39.53 | 600 / 605 |
bladder | 100% | 2552.38 | 21 / 21 | 99% | 28.04 | 497 / 504 |
stomach | 100% | 1947.76 | 359 / 359 | 98% | 35.70 | 280 / 286 |
uterus | 100% | 2543.04 | 170 / 170 | 98% | 26.02 | 449 / 459 |
pancreas | 100% | 2481.40 | 328 / 328 | 97% | 25.78 | 173 / 178 |
kidney | 100% | 1281.92 | 89 / 89 | 97% | 33.85 | 874 / 901 |
intestine | 100% | 2320.50 | 966 / 966 | 97% | 31.61 | 510 / 527 |
liver | 100% | 1741.71 | 226 / 226 | 94% | 19.43 | 380 / 406 |
skin | 100% | 2671.67 | 1808 / 1809 | 90% | 23.92 | 425 / 472 |
blood vessel | 100% | 2937.06 | 1335 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 2556.60 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 1772.99 | 241 / 241 | 0% | 0 | 0 / 0 |
adipose | 100% | 2324.99 | 1203 / 1204 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 23.46 | 44 / 45 |
heart | 96% | 1677.27 | 829 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 86% | 19.79 | 25 / 29 |
eye | 0% | 0 | 0 / 0 | 63% | 11.75 | 50 / 80 |
peripheral blood | 50% | 1240.99 | 464 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0032434 | Biological process | regulation of proteasomal ubiquitin-dependent protein catabolic process |
GO_0006281 | Biological process | DNA repair |
GO_0002841 | Biological process | negative regulation of T cell mediated immune response to tumor cell |
GO_0034976 | Biological process | response to endoplasmic reticulum stress |
GO_0060252 | Biological process | positive regulation of glial cell proliferation |
GO_0001649 | Biological process | osteoblast differentiation |
GO_0033146 | Biological process | regulation of intracellular estrogen receptor signaling pathway |
GO_1903895 | Biological process | negative regulation of IRE1-mediated unfolded protein response |
GO_0140501 | Biological process | positive regulation of reticulophagy |
GO_0006974 | Biological process | DNA damage response |
GO_0032880 | Biological process | regulation of protein localization |
GO_0050868 | Biological process | negative regulation of T cell activation |
GO_1990592 | Biological process | protein K69-linked ufmylation |
GO_0050727 | Biological process | regulation of inflammatory response |
GO_0072344 | Biological process | rescue of stalled ribosome |
GO_0032088 | Biological process | negative regulation of NF-kappaB transcription factor activity |
GO_0032790 | Biological process | ribosome disassembly |
GO_0071569 | Biological process | protein ufmylation |
GO_0060218 | Biological process | hematopoietic stem cell differentiation |
GO_0030218 | Biological process | erythrocyte differentiation |
GO_0031397 | Biological process | negative regulation of protein ubiquitination |
GO_0043066 | Biological process | negative regulation of apoptotic process |
GO_0010508 | Biological process | positive regulation of autophagy |
GO_0008284 | Biological process | positive regulation of cell population proliferation |
GO_0061709 | Biological process | reticulophagy |
GO_0043122 | Biological process | regulation of canonical NF-kappaB signal transduction |
GO_1902065 | Biological process | response to L-glutamate |
GO_0000077 | Biological process | DNA damage checkpoint signaling |
GO_0016020 | Cellular component | membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0032991 | Cellular component | protein-containing complex |
GO_0043005 | Cellular component | neuron projection |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005741 | Cellular component | mitochondrial outer membrane |
GO_0035861 | Cellular component | site of double-strand break |
GO_0005634 | Cellular component | nucleus |
GO_0019901 | Molecular function | protein kinase binding |
GO_0061666 | Molecular function | UFM1 ligase activity |
GO_0071568 | Molecular function | UFM1 transferase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | UFL1 |
Protein name | E3 UFM1-protein ligase 1 (EC 2.3.2.-) (E3 UFM1-protein transferase 1) (Multiple alpha-helix protein located at ER) (Novel LZAP-binding protein) (Regulator of C53/LZAP and DDRGK1) |
Synonyms | KIAA0776 NLBP MAXER RCAD |
Description | FUNCTION: E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to lysine residues on target proteins, and which plays a key role in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress . In response to endoplasmic reticulum stress, recruited to the endoplasmic reticulum membrane by DDRGK1, and mediates ufmylation of proteins such as RPN1 and RPL26/uL24, thereby promoting reticulophagy of endoplasmic reticulum sheets . Ufmylation-dependent reticulophagy inhibits the unfolded protein response (UPR) via ERN1/IRE1-alpha . Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis, blood vessel morphogenesis or inflammatory response . Regulates inflammation in response to endoplasmic reticulum stress by promoting reticulophagy, leading to inhibit the activity of the NF-kappa-B transcription factor (By similarity). Mediates ufmylation of DDRGK1 and CDK5RAP3; the role of these modifications is however unclear: as both DDRGK1 and CDK5RAP3 act as substrate adapters for ufmylation, it is uncertain whether ufmylation of these proteins is a collateral effect or is required for ufmylation . Catalyzes ufmylation of various subunits of the ribosomal complex or associated components, such as RPS3/uS3, RPS20/uS10, RPL10/uL16, RPL26/uL24 and EIF6 (By similarity). Anchors CDK5RAP3 in the cytoplasm, preventing its translocation to the nucleus which allows expression of the CCND1 cyclin and progression of cells through the G1/S transition . Also involved in the response to DNA damage: recruited to double-strand break sites following DNA damage and mediates monoufmylation of histone H4 . Catalyzes ufmylation of TRIP4, thereby playing a role in nuclear receptor-mediated transcription . Required for hematopoietic stem cell function and hematopoiesis (By similarity). Required for cardiac homeostasis (By similarity). . |
Accessions | ENST00000369278.5 [O94874-1] O94874 |