ACTR3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	44 studies	31% ± 12%	Explore
macrophage	43 studies	44% ± 17%	Explore
B cell	42 studies	45% ± 15%	Explore
natural killer cell	42 studies	47% ± 15%	Explore
T cell	37 studies	40% ± 17%	Explore
CD8-positive, alpha-beta T cell	36 studies	45% ± 18%	Explore
fibroblast	35 studies	23% ± 8%	Explore
CD4-positive, alpha-beta T cell	33 studies	46% ± 18%	Explore
smooth muscle cell	29 studies	31% ± 9%	Explore
pericyte	29 studies	28% ± 9%	Explore
dendritic cell	28 studies	50% ± 21%	Explore
conventional dendritic cell	28 studies	65% ± 13%	Explore
classical monocyte	26 studies	47% ± 15%	Explore
regulatory T cell	26 studies	50% ± 16%	Explore
monocyte	24 studies	47% ± 15%	Explore
non-classical monocyte	24 studies	63% ± 13%	Explore
mast cell	23 studies	39% ± 17%	Explore
mature NK T cell	20 studies	45% ± 12%	Explore
memory B cell	20 studies	49% ± 10%	Explore
naive B cell	20 studies	41% ± 10%	Explore
basal cell	20 studies	35% ± 16%	Explore
epithelial cell	19 studies	37% ± 19%	Explore
endothelial cell of lymphatic vessel	18 studies	30% ± 8%	Explore
gamma-delta T cell	18 studies	48% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	37% ± 10%	Explore
plasmacytoid dendritic cell	18 studies	40% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	43% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	49% ± 13%	Explore
myeloid cell	16 studies	50% ± 19%	Explore
capillary endothelial cell	15 studies	26% ± 9%	Explore
mucosal invariant T cell	14 studies	38% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	43% ± 12%	Explore
myofibroblast cell	14 studies	29% ± 10%	Explore
microglial cell	14 studies	37% ± 14%	Explore
plasma cell	13 studies	39% ± 17%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	43% ± 18%	Explore
ciliated cell	13 studies	33% ± 15%	Explore
connective tissue cell	13 studies	27% ± 11%	Explore
endothelial cell of vascular tree	13 studies	32% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	45% ± 20%	Explore
neutrophil	12 studies	38% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	40% ± 11%	Explore
endothelial cell of artery	12 studies	28% ± 8%	Explore
vein endothelial cell	12 studies	30% ± 11%	Explore
plasmablast	10 studies	45% ± 22%	Explore
secretory cell	10 studies	30% ± 12%	Explore
leukocyte	10 studies	42% ± 11%	Explore
oligodendrocyte	10 studies	24% ± 9%	Explore
platelet	9 studies	27% ± 8%	Explore
oligodendrocyte precursor cell	9 studies	26% ± 12%	Explore
alveolar macrophage	8 studies	51% ± 12%	Explore
type I pneumocyte	8 studies	26% ± 6%	Explore
innate lymphoid cell	8 studies	40% ± 10%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	52% ± 23%	Explore
goblet cell	8 studies	31% ± 17%	Explore
T follicular helper cell	8 studies	48% ± 7%	Explore
mononuclear phagocyte	7 studies	51% ± 16%	Explore
GABAergic neuron	7 studies	33% ± 14%	Explore
neuron	7 studies	39% ± 18%	Explore
abnormal cell	7 studies	35% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	41% ± 15%	Explore
hematopoietic precursor cell	6 studies	50% ± 21%	Explore
club cell	6 studies	23% ± 8%	Explore
kidney loop of Henle epithelial cell	6 studies	18% ± 2%	Explore
progenitor cell	6 studies	30% ± 17%	Explore
megakaryocyte	6 studies	62% ± 19%	Explore
hematopoietic stem cell	6 studies	35% ± 10%	Explore
lymphocyte	6 studies	46% ± 14%	Explore
precursor B cell	6 studies	55% ± 13%	Explore
mesothelial cell	6 studies	28% ± 13%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	52% ± 18%	Explore
astrocyte	6 studies	30% ± 12%	Explore
CD4-positive helper T cell	5 studies	33% ± 9%	Explore
exhausted T cell	5 studies	57% ± 13%	Explore
respiratory goblet cell	5 studies	29% ± 10%	Explore
pro-B cell	5 studies	36% ± 12%	Explore
brush cell	5 studies	29% ± 12%	Explore
T-helper 17 cell	5 studies	59% ± 19%	Explore
immature B cell	5 studies	55% ± 21%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	62% ± 22%	Explore
glutamatergic neuron	5 studies	47% ± 17%	Explore
interneuron	5 studies	35% ± 18%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	39% ± 16%	Explore
squamous epithelial cell	4 studies	41% ± 21%	Explore
type II pneumocyte	4 studies	25% ± 11%	Explore
mucus secreting cell	4 studies	21% ± 2%	Explore
inflammatory macrophage	4 studies	39% ± 17%	Explore
germinal center B cell	4 studies	67% ± 15%	Explore
intermediate monocyte	4 studies	57% ± 20%	Explore
granulocyte	4 studies	45% ± 18%	Explore
group 3 innate lymphoid cell	4 studies	56% ± 13%	Explore
keratinocyte	4 studies	32% ± 15%	Explore
T-helper 1 cell	4 studies	60% ± 13%	Explore
double negative thymocyte	4 studies	55% ± 14%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	55% ± 22%	Explore
hillock cell	3 studies	21% ± 6%	Explore
ionocyte	3 studies	30% ± 7%	Explore
pancreatic A cell	3 studies	47% ± 7%	Explore
monocyte-derived dendritic cell	3 studies	49% ± 23%	Explore
glomerular endothelial cell	3 studies	21% ± 4%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	20% ± 2%	Explore
renal alpha-intercalated cell	3 studies	25% ± 7%	Explore
glial cell	3 studies	29% ± 12%	Explore
retinal ganglion cell	3 studies	57% ± 25%	Explore
extravillous trophoblast	3 studies	48% ± 11%	Explore
placental villous trophoblast	3 studies	25% ± 5%	Explore
erythroblast	3 studies	53% ± 23%	Explore
tissue-resident macrophage	3 studies	49% ± 3%	Explore
intraepithelial lymphocyte	3 studies	56% ± 13%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	25% ± 7%	Explore
luminal cell of prostate epithelium	3 studies	22% ± 8%	Explore
muscle cell	3 studies	45% ± 17%	Explore
pancreatic ductal cell	3 studies	52% ± 20%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	69% ± 7%	Explore
enteroendocrine cell	3 studies	36% ± 10%	Explore
transit amplifying cell	3 studies	34% ± 24%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	50% ± 12%	Explore
myoepithelial cell	3 studies	42% ± 5%	Explore
progenitor cell of mammary luminal epithelium	3 studies	23% ± 4%	Explore
erythrocyte	3 studies	42% ± 22%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	20 studies	34% ± 12%	Explore
peripheral blood	20 studies	44% ± 14%	Explore
brain	13 studies	30% ± 13%	Explore
intestine	10 studies	27% ± 9%	Explore
kidney	8 studies	29% ± 11%	Explore
bone marrow	5 studies	36% ± 15%	Explore
lymph node	5 studies	41% ± 11%	Explore
liver	5 studies	43% ± 20%	Explore
uterus	4 studies	39% ± 14%	Explore
breast	4 studies	29% ± 4%	Explore
adipose	4 studies	25% ± 9%	Explore
pancreas	3 studies	44% ± 9%	Explore
placenta	3 studies	39% ± 7%	Explore
eye	3 studies	29% ± 9%	Explore
heart	3 studies	20% ± 1%	Explore
prostate	3 studies	37% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	10790.35	1445 / 1445	100%	93.17	183 / 183
intestine	100%	8600.69	966 / 966	100%	72.49	527 / 527
ovary	100%	4833.20	180 / 180	100%	62.77	430 / 430
stomach	100%	5998.98	359 / 359	100%	70.98	286 / 286
breast	100%	7616.22	459 / 459	100%	69.70	1117 / 1118
lung	100%	9634.30	577 / 578	100%	86.74	1155 / 1155
bladder	100%	8545.57	21 / 21	100%	65.60	503 / 504
uterus	100%	7989.92	170 / 170	100%	70.17	458 / 459
thymus	100%	5503.46	652 / 653	100%	42.42	602 / 605
prostate	100%	5777.93	244 / 245	99%	42.02	497 / 502
brain	98%	4630.38	2597 / 2642	100%	45.06	705 / 705
kidney	100%	5719.51	89 / 89	98%	51.01	879 / 901
skin	100%	11639.71	1808 / 1809	97%	62.42	460 / 472
adrenal gland	100%	11697.26	258 / 258	95%	34.59	218 / 230
pancreas	90%	2904.76	296 / 328	99%	61.79	176 / 178
liver	93%	2971.88	211 / 226	89%	24.90	363 / 406
adipose	100%	8977.80	1204 / 1204	0%	0	0 / 0
blood vessel	100%	11371.05	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	127.39	29 / 29
spleen	100%	10378.67	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	74.55	45 / 45
ureter	0%	0	0 / 0	100%	20.24	1 / 1
peripheral blood	99%	18381.07	922 / 929	0%	0	0 / 0
muscle	95%	3081.83	766 / 803	0%	0	0 / 0
heart	93%	4509.30	800 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	75%	23.30	60 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0033206	Biological process	meiotic cytokinesis
GO_0060271	Biological process	cilium assembly
GO_0070358	Biological process	actin polymerization-dependent cell motility
GO_0016344	Biological process	meiotic chromosome movement towards spindle pole
GO_0008356	Biological process	asymmetric cell division
GO_0007163	Biological process	establishment or maintenance of cell polarity
GO_0010592	Biological process	positive regulation of lamellipodium assembly
GO_0034314	Biological process	Arp2/3 complex-mediated actin nucleation
GO_0051653	Biological process	spindle localization
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0071346	Biological process	cellular response to type II interferon
GO_0005903	Cellular component	brush border
GO_0005885	Cellular component	Arp2/3 protein complex
GO_0016020	Cellular component	membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005925	Cellular component	focal adhesion
GO_0005911	Cellular component	cell-cell junction
GO_0015629	Cellular component	actin cytoskeleton
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0030027	Cellular component	lamellipodium
GO_0035861	Cellular component	site of double-strand break
GO_0005634	Cellular component	nucleus
GO_0005200	Molecular function	structural constituent of cytoskeleton
GO_0051015	Molecular function	actin filament binding
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ACTR3
Protein name	Actin-related protein 3 (Actin-like protein 3) Actin related protein 3
Synonyms	ARP3
Description	FUNCTION: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) . The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility . Seems to contact the pointed end of the daughter actin filament . In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation . In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA . The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) . Plays a role in ciliogenesis . .
Accessions	F8WE84 P61158 ENST00000443297.5 ENST00000263238.7 ENST00000446821.5 F8WEW2 ENST00000415792.5 F8WDR7 B4DXW1 ENST00000535589.3

ACTR3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review