VCP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0006281Biological processDNA repair
GO_0016236Biological processmacroautophagy
GO_0046034Biological processATP metabolic process
GO_0031334Biological processpositive regulation of protein-containing complex assembly
GO_1903007Biological processpositive regulation of Lys63-specific deubiquitinase activity
GO_0051228Biological processmitotic spindle disassembly
GO_0006914Biological processautophagy
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_2001171Biological processpositive regulation of ATP biosynthetic process
GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0006734Biological processNADH metabolic process
GO_0006302Biological processdouble-strand break repair
GO_0072389Biological processflavin adenine dinucleotide catabolic process
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0045879Biological processnegative regulation of smoothened signaling pathway
GO_0030968Biological processendoplasmic reticulum unfolded protein response
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0050807Biological processregulation of synapse organization
GO_0042981Biological processregulation of apoptotic process
GO_0035617Biological processstress granule disassembly
GO_0061857Biological processendoplasmic reticulum stress-induced pre-emptive quality control
GO_0010918Biological processpositive regulation of mitochondrial membrane potential
GO_0016567Biological processprotein ubiquitination
GO_0036297Biological processinterstrand cross-link repair
GO_1903843Biological processcellular response to arsenite ion
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_0010498Biological processproteasomal protein catabolic process
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_1903006Biological processpositive regulation of protein K63-linked deubiquitination
GO_0120186Biological processnegative regulation of protein localization to chromatin
GO_0032510Biological processendosome to lysosome transport via multivesicular body sorting pathway
GO_1903862Biological processpositive regulation of oxidative phosphorylation
GO_0097352Biological processautophagosome maturation
GO_1905634Biological processregulation of protein localization to chromatin
GO_0019079Biological processviral genome replication
GO_0036503Biological processERAD pathway
GO_0030970Biological processretrograde protein transport, ER to cytosol
GO_0034605Biological processcellular response to heat
GO_0045184Biological processestablishment of protein localization
GO_0006974Biological processDNA damage response
GO_0071218Biological processcellular response to misfolded protein
GO_0106300Biological processprotein-DNA covalent cross-linking repair
GO_1903715Biological processregulation of aerobic respiration
GO_0070842Biological processaggresome assembly
GO_0006888Biological processendoplasmic reticulum to Golgi vesicle-mediated transport
GO_0019985Biological processtranslesion synthesis
GO_0035578Cellular componentazurophil granule lumen
GO_0098978Cellular componentglutamatergic synapse
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0034098Cellular componentVCP-NPL4-UFD1 AAA ATPase complex
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005634Cellular componentnucleus
GO_0000502Cellular componentproteasome complex
GO_0005576Cellular componentextracellular region
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_1990730Cellular componentVCP-NSFL1C complex
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_1904949Cellular componentATPase complex
GO_0036513Cellular componentDerlin-1 retrotranslocation complex
GO_0035861Cellular componentsite of double-strand break
GO_0005811Cellular componentlipid droplet
GO_0032991Cellular componentprotein-containing complex
GO_0034774Cellular componentsecretory granule lumen
GO_0005783Cellular componentendoplasmic reticulum
GO_0005737Cellular componentcytoplasm
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005829Cellular componentcytosol
GO_0042802Molecular functionidentical protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0042288Molecular functionMHC class I protein binding
GO_0035800Molecular functiondeubiquitinase activator activity
GO_0005524Molecular functionATP binding
GO_0031593Molecular functionpolyubiquitin modification-dependent protein binding
GO_1990381Molecular functionubiquitin-specific protease binding
GO_1904288Molecular functionBAT3 complex binding
GO_0043531Molecular functionADP binding
GO_0019904Molecular functionprotein domain specific binding
GO_0008289Molecular functionlipid binding
GO_0036435Molecular functionK48-linked polyubiquitin modification-dependent protein binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0019903Molecular functionprotein phosphatase binding
GO_0140036Molecular functionubiquitin-modified protein reader activity
GO_0016887Molecular functionATP hydrolysis activity
GO_0044389Molecular functionubiquitin-like protein ligase binding

IV. Literature review

[source]
Gene nameVCP
Protein nameTransitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP)
Valosin containing protein
Transitional endoplasmic reticulum ATPase (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein)
vesicle-fusing ATPase (EC 3.6.4.6)
Transitional endoplasmic reticulum ATPase (EC 3.6.4.6) (Valosin-containing protein)
Valosin-containing protein
VCP protein
SynonymsHEL-220
HEL-S-70
DescriptionFUNCTION: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex . Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation . Involved in clearance process by mediating G3BP1 extraction from stress granules . Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites . Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage . Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis . Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal . Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation . Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy . Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI . May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation . May more particularly play a role in caveolins sorting in cells . By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway . .

AccessionsENST00000680834.1
A0A7P0T8A3
ENST00000681789.1
P55072
ENST00000678650.1
ENST00000680916.1
A0A7P0T971
ENST00000358901.11
ENST00000448530.6
ENST00000678465.1
A0A7P0TAW3
A0A7I2YQJ0
A0A7P0TBF1
A0A7P0T8Q4
A0A7P0TBK7
ENST00000681335.1
ENST00000678018.1
ENST00000681386.1
ENST00000679862.1
ENST00000679647.1
ENST00000679204.2
ENST00000680079.1
ENST00000680731.1
Q96IF9
A0A7P0T946
ENST00000681537.1
ENST00000679902.1
Q9HAP1
ENST00000680520.1
ENST00000681562.1
A0A7P0T8D6
A0A7P0T8D3
A0A7P0TAQ1
A0A7P0TA22
C9JUP7
ENST00000679449.1
Q9HAP0
Q0IIN5
ENST00000677257.1
ENST00000417448.2
ENST00000681125.1
A0A7I2V540
ENST00000680900.1
A0A7I2V5G8
A0A7P0T9X5
A0A7P0Z4C6
A0A7P0T8Q5
A0A7I2V2Y2
A0A7P0TAY0
A0A7P0Z4D1