PARP3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PARP3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PARP3 at tissue level.

III. Associated gene sets

GO_0051106Biological processpositive regulation of DNA ligation
GO_0006302Biological processdouble-strand break repair
GO_1905662Biological processnegative regulation of telomerase RNA reverse transcriptase activity
GO_0030592Biological processDNA ADP-ribosylation
GO_0070212Biological processprotein poly-ADP-ribosylation
GO_0000723Biological processtelomere maintenance
GO_1990166Biological processprotein localization to site of double-strand break
GO_0060236Biological processregulation of mitotic spindle organization
GO_0070213Biological processprotein auto-ADP-ribosylation
GO_0045829Biological processnegative regulation of isotype switching
GO_2001034Biological processpositive regulation of double-strand break repair via nonhomologous end joining
GO_0005730Cellular componentnucleolus
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0045171Cellular componentintercellular bridge
GO_0005814Cellular componentcentriole
GO_0016604Cellular componentnuclear body
GO_0005737Cellular componentcytoplasm
GO_0035861Cellular componentsite of double-strand break
GO_0016779Molecular functionnucleotidyltransferase activity
GO_0003950Molecular functionNAD+ ADP-ribosyltransferase activity
GO_0140807Molecular functionNAD+-protein-glutamate ADP-ribosyltransferase activity
GO_0003824Molecular functioncatalytic activity
GO_0140804Molecular functionNAD+- protein-lysine ADP-ribosyltransferase activity
GO_0140806Molecular functionNAD+- protein-aspartate ADP-ribosyltransferase activity
GO_0140294Molecular functionNAD DNA ADP-ribosyltransferase activity
GO_1990404Molecular functionNAD+-protein ADP-ribosyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePARP3
Protein nameProtein mono-ADP-ribosyltransferase PARP3 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 3) (ARTD3) (DNA ADP-ribosyltransferase PARP3) (EC 2.4.2.-) (IRT1) (NAD(+) ADP-ribosyltransferase 3) (ADPRT-3) (Poly [ADP-ribose] polymerase 3) (PARP-3) (hPARP-3) (Poly[ADP-ribose] synthase 3) (pADPRT-3)
Protein mono-ADP-ribosyltransferase PARP3
SynonymsADPRTL3
ADPRT3
DescriptionFUNCTION: Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage . Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins . In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation . Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as histone H2B, XRCC5 and XRCC6 . ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks . Involved in single-strand break repair by catalyzing mono-ADP-ribosylation of histone H2B on 'Glu-2' (H2BE2ADPr) of nucleosomes containing nicked DNA . Cooperates with the XRCC5-XRCC6 (Ku80-Ku70) heterodimer to limit end-resection thereby promoting accurate NHEJ . Suppresses G-quadruplex (G4) structures in response to DNA damage . Associates with a number of DNA repair factors and is involved in the response to exogenous and endogenous DNA strand breaks . Together with APLF, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) . May link the DNA damage surveillance network to the mitotic fidelity checkpoint . Acts as a negative regulator of immunoglobulin class switch recombination, probably by controlling the level of AICDA /AID on the chromatin (By similarity). In addition to proteins, also able to ADP-ribosylate DNA: mediates DNA mono-ADP-ribosylation of DNA strand break termini via covalent addition of a single ADP-ribose moiety to a 5'- or 3'-terminal phosphate residues in DNA containing multiple strand breaks . .

AccessionsF8WAY7
ENST00000431474.6 [Q9Y6F1-1]
ENST00000471971.6 [Q9Y6F1-1]
ENST00000498510.2 [Q9Y6F1-1]
C9J9C7
ENST00000498510
Q9Y6F1
ENST00000417220.6 [Q9Y6F1-1]
ENST00000471971
ENST00000398755.8 [Q9Y6F1-1]