RAD51 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of RAD51 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RAD51 at tissue level.

III. Associated gene sets

GO_0010569Biological processregulation of double-strand break repair via homologous recombination
GO_0006281Biological processDNA repair
GO_1990426Biological processmitotic recombination-dependent replication fork processing
GO_1990414Biological processreplication-born double-strand break repair via sister chromatid exchange
GO_0036297Biological processinterstrand cross-link repair
GO_0010833Biological processtelomere maintenance via telomere lengthening
GO_0051106Biological processpositive regulation of DNA ligation
GO_0006268Biological processDNA unwinding involved in DNA replication
GO_0007131Biological processreciprocal meiotic recombination
GO_0006974Biological processDNA damage response
GO_0072711Biological processcellular response to hydroxyurea
GO_0000722Biological processtelomere maintenance via recombination
GO_0001932Biological processregulation of protein phosphorylation
GO_0000730Biological processDNA recombinase assembly
GO_0072757Biological processcellular response to camptothecin
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0051321Biological processmeiotic cell cycle
GO_0031297Biological processreplication fork processing
GO_0070192Biological processchromosome organization involved in meiotic cell cycle
GO_1990918Biological processdouble-strand break repair involved in meiotic recombination
GO_0006310Biological processDNA recombination
GO_2000001Biological processregulation of DNA damage checkpoint
GO_0006312Biological processmitotic recombination
GO_0042148Biological processDNA strand invasion
GO_0071479Biological processcellular response to ionizing radiation
GO_0005730Cellular componentnucleolus
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005739Cellular componentmitochondrion
GO_0000228Cellular componentnuclear chromosome
GO_0005813Cellular componentcentrosome
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0099182Cellular componentpresynaptic intermediate filament cytoskeleton
GO_0005759Cellular componentmitochondrial matrix
GO_0016605Cellular componentPML body
GO_0000152Cellular componentnuclear ubiquitin ligase complex
GO_0005737Cellular componentcytoplasm
GO_0000800Cellular componentlateral element
GO_0000794Cellular componentcondensed nuclear chromosome
GO_0000781Cellular componentchromosome, telomeric region
GO_0000793Cellular componentcondensed chromosome
GO_0001673Cellular componentmale germ cell nucleus
GO_0000785Cellular componentchromatin
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0003682Molecular functionchromatin binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0070182Molecular functionDNA polymerase binding
GO_0140664Molecular functionATP-dependent DNA damage sensor activity
GO_0042802Molecular functionidentical protein binding
GO_0017116Molecular functionsingle-stranded DNA helicase activity
GO_0005524Molecular functionATP binding
GO_0000150Molecular functionDNA strand exchange activity
GO_0008094Molecular functionATP-dependent activity, acting on DNA
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameRAD51
Protein nameDNA repair protein RAD51 homolog 1 (HsRAD51) (hRAD51) (RAD51 homolog A)
RAD51
RAD51 recombinase
SynonymsRECA
RAD51A
DescriptionFUNCTION: Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) . Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange . Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template . Recruited to resolve stalled replication forks during replication stress . Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR . Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3 . Also involved in interstrand cross-link repair . .

AccessionsENST00000557850.5 [Q06609-2]
ENST00000382643.7 [Q06609-4]
E9PI54
Q9NZG9
E9PNT5
ENST00000531277.2
Q06609
E9PJ30
H0YD61
ENST00000527860.5
ENST00000533741.1
ENST00000526763.6
ENST00000525066.5
ENST00000423169.6 [Q06609-3]
ENST00000267868.8 [Q06609-1]
ENST00000645673.2 [Q06609-4]
ENST00000532743.6 [Q06609-1]