ARPC5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	43 studies	61% ± 20%	Explore
natural killer cell	40 studies	48% ± 16%	Explore
endothelial cell	37 studies	36% ± 15%	Explore
CD8-positive, alpha-beta T cell	36 studies	44% ± 19%	Explore
B cell	35 studies	40% ± 14%	Explore
T cell	33 studies	41% ± 18%	Explore
fibroblast	32 studies	39% ± 12%	Explore
CD4-positive, alpha-beta T cell	31 studies	44% ± 20%	Explore
pericyte	29 studies	45% ± 17%	Explore
classical monocyte	29 studies	67% ± 16%	Explore
conventional dendritic cell	28 studies	74% ± 12%	Explore
dendritic cell	27 studies	60% ± 20%	Explore
smooth muscle cell	27 studies	46% ± 19%	Explore
monocyte	25 studies	58% ± 23%	Explore
regulatory T cell	25 studies	42% ± 16%	Explore
non-classical monocyte	24 studies	80% ± 12%	Explore
plasmacytoid dendritic cell	21 studies	57% ± 14%	Explore
memory B cell	20 studies	37% ± 11%	Explore
epithelial cell	20 studies	34% ± 20%	Explore
mast cell	19 studies	41% ± 17%	Explore
mature NK T cell	18 studies	44% ± 9%	Explore
basal cell	18 studies	35% ± 17%	Explore
naive B cell	18 studies	33% ± 9%	Explore
endothelial cell of lymphatic vessel	17 studies	48% ± 14%	Explore
gamma-delta T cell	17 studies	46% ± 14%	Explore
myeloid cell	17 studies	57% ± 26%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	37% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	51% ± 11%	Explore
neutrophil	15 studies	51% ± 16%	Explore
connective tissue cell	15 studies	44% ± 16%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	42% ± 15%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	46% ± 13%	Explore
plasma cell	13 studies	38% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	40% ± 18%	Explore
capillary endothelial cell	12 studies	36% ± 9%	Explore
myofibroblast cell	12 studies	47% ± 16%	Explore
mucosal invariant T cell	12 studies	36% ± 7%	Explore
platelet	11 studies	54% ± 18%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	43% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	41% ± 13%	Explore
endothelial cell of artery	11 studies	43% ± 15%	Explore
vein endothelial cell	11 studies	34% ± 10%	Explore
endothelial cell of vascular tree	11 studies	33% ± 10%	Explore
type I pneumocyte	10 studies	40% ± 14%	Explore
plasmablast	10 studies	46% ± 21%	Explore
secretory cell	10 studies	35% ± 14%	Explore
abnormal cell	10 studies	33% ± 16%	Explore
leukocyte	9 studies	48% ± 16%	Explore
mesothelial cell	9 studies	45% ± 18%	Explore
innate lymphoid cell	8 studies	38% ± 13%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	54% ± 23%	Explore
T follicular helper cell	8 studies	40% ± 7%	Explore
oligodendrocyte	8 studies	29% ± 10%	Explore
alveolar macrophage	7 studies	66% ± 17%	Explore
type II pneumocyte	7 studies	29% ± 15%	Explore
club cell	7 studies	33% ± 12%	Explore
goblet cell	7 studies	25% ± 10%	Explore
ciliated cell	7 studies	37% ± 16%	Explore
microglial cell	7 studies	35% ± 15%	Explore
hematopoietic precursor cell	6 studies	54% ± 19%	Explore
respiratory goblet cell	6 studies	29% ± 14%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	56% ± 25%	Explore
mononuclear phagocyte	6 studies	69% ± 18%	Explore
progenitor cell	6 studies	37% ± 19%	Explore
megakaryocyte	6 studies	70% ± 22%	Explore
hematopoietic stem cell	6 studies	47% ± 13%	Explore
precursor B cell	6 studies	47% ± 13%	Explore
neuron	6 studies	47% ± 17%	Explore
intermediate monocyte	6 studies	68% ± 25%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	50% ± 18%	Explore
glutamatergic neuron	6 studies	32% ± 11%	Explore
CD4-positive helper T cell	5 studies	30% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	40% ± 15%	Explore
exhausted T cell	5 studies	57% ± 16%	Explore
ionocyte	5 studies	27% ± 14%	Explore
enterocyte	5 studies	26% ± 8%	Explore
enteroendocrine cell	5 studies	43% ± 17%	Explore
transit amplifying cell	5 studies	22% ± 4%	Explore
brush cell	5 studies	43% ± 15%	Explore
double negative thymocyte	5 studies	61% ± 14%	Explore
granulocyte	5 studies	44% ± 21%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	39% ± 15%	Explore
squamous epithelial cell	4 studies	39% ± 24%	Explore
pancreatic A cell	4 studies	58% ± 20%	Explore
type B pancreatic cell	4 studies	50% ± 22%	Explore
kidney loop of Henle epithelial cell	4 studies	21% ± 3%	Explore
pro-B cell	4 studies	47% ± 10%	Explore
immature B cell	4 studies	49% ± 10%	Explore
adventitial cell	4 studies	33% ± 9%	Explore
inflammatory macrophage	4 studies	53% ± 12%	Explore
germinal center B cell	4 studies	57% ± 13%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	24% ± 5%	Explore
group 3 innate lymphoid cell	4 studies	50% ± 16%	Explore
T-helper 17 cell	4 studies	53% ± 22%	Explore
interneuron	4 studies	24% ± 7%	Explore
oligodendrocyte precursor cell	4 studies	24% ± 4%	Explore
erythrocyte	4 studies	30% ± 15%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	51% ± 26%	Explore
pancreatic D cell	3 studies	56% ± 24%	Explore
monocyte-derived dendritic cell	3 studies	69% ± 28%	Explore
glomerular endothelial cell	3 studies	33% ± 1%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	23% ± 5%	Explore
epithelial cell of proximal tubule	3 studies	16% ± 1%	Explore
neural crest cell	3 studies	28% ± 5%	Explore
extravillous trophoblast	3 studies	76% ± 10%	Explore
placental villous trophoblast	3 studies	74% ± 20%	Explore
erythroblast	3 studies	37% ± 21%	Explore
lymphocyte	3 studies	61% ± 9%	Explore
neuroendocrine cell	3 studies	44% ± 10%	Explore
tissue-resident macrophage	3 studies	52% ± 16%	Explore
intraepithelial lymphocyte	3 studies	52% ± 14%	Explore
myoepithelial cell	3 studies	50% ± 14%	Explore
muscle cell	3 studies	40% ± 22%	Explore
GABAergic neuron	3 studies	24% ± 4%	Explore
pancreatic ductal cell	3 studies	70% ± 13%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	66% ± 11%	Explore
glial cell	3 studies	42% ± 19%	Explore
keratinocyte	3 studies	31% ± 8%	Explore
T-helper 1 cell	3 studies	58% ± 17%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	48% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	49% ± 14%	Explore
lung	19 studies	42% ± 17%	Explore
intestine	11 studies	30% ± 11%	Explore
brain	11 studies	29% ± 9%	Explore
kidney	7 studies	35% ± 11%	Explore
bone marrow	5 studies	38% ± 14%	Explore
lymph node	5 studies	45% ± 9%	Explore
liver	5 studies	41% ± 17%	Explore
pancreas	4 studies	54% ± 21%	Explore
eye	4 studies	20% ± 5%	Explore
uterus	4 studies	53% ± 15%	Explore
breast	4 studies	32% ± 6%	Explore
placenta	3 studies	71% ± 11%	Explore
heart	3 studies	23% ± 9%	Explore
adipose	3 studies	27% ± 10%	Explore
adrenal gland	3 studies	30% ± 9%	Explore
skin	3 studies	29% ± 12%	Explore
prostate	3 studies	25% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6988.72	1445 / 1445	100%	55.35	183 / 183
liver	100%	3379.75	226 / 226	100%	45.95	406 / 406
lung	100%	11389.84	578 / 578	100%	69.40	1155 / 1155
ovary	100%	4086.82	180 / 180	100%	68.74	430 / 430
uterus	100%	8609.31	170 / 170	100%	82.36	459 / 459
thymus	100%	6198.31	653 / 653	100%	47.46	604 / 605
intestine	100%	7190.13	966 / 966	100%	62.95	526 / 527
bladder	100%	6137.76	21 / 21	100%	67.02	503 / 504
breast	100%	7101.50	459 / 459	100%	68.45	1113 / 1118
stomach	99%	4320.94	357 / 359	100%	58.32	286 / 286
prostate	100%	5687.21	244 / 245	99%	35.33	497 / 502
brain	98%	3842.45	2600 / 2642	100%	43.93	705 / 705
kidney	100%	5000.26	89 / 89	98%	44.01	886 / 901
skin	100%	8439.06	1807 / 1809	98%	62.19	464 / 472
adrenal gland	100%	5352.90	258 / 258	96%	30.74	220 / 230
pancreas	92%	2675.54	303 / 328	99%	68.83	177 / 178
adipose	100%	8121.11	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	130.14	29 / 29
spleen	100%	12107.42	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	67.50	45 / 45
ureter	0%	0	0 / 0	100%	50.91	1 / 1
blood vessel	100%	8249.96	1334 / 1335	0%	0	0 / 0
peripheral blood	100%	21820.76	927 / 929	0%	0	0 / 0
heart	94%	2947.13	810 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	79%	17.61	63 / 80
muscle	15%	254.04	119 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0030833	Biological process	regulation of actin filament polymerization
GO_0034314	Biological process	Arp2/3 complex-mediated actin nucleation
GO_0030036	Biological process	actin cytoskeleton organization
GO_0016477	Biological process	cell migration
GO_0005885	Cellular component	Arp2/3 protein complex
GO_0005576	Cellular component	extracellular region
GO_0070062	Cellular component	extracellular exosome
GO_0034774	Cellular component	secretory granule lumen
GO_0005925	Cellular component	focal adhesion
GO_0015629	Cellular component	actin cytoskeleton
GO_1904813	Cellular component	ficolin-1-rich granule lumen
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0030027	Cellular component	lamellipodium
GO_0035861	Cellular component	site of double-strand break
GO_0005634	Cellular component	nucleus
GO_0005200	Molecular function	structural constituent of cytoskeleton
GO_0051015	Molecular function	actin filament binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ARPC5
Protein name	ARPC5 protein Actin-related protein 2/3 complex subunit 5 Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC)
Synonyms	ARC16
Description	FUNCTION: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) . The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility . In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA . The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) . . FUNCTION: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. .
Accessions	B1ALC0 ENST00000367534.5 Q6IPM3 ENST00000294742.6 [O15511-2] O15511 ENST00000359856.11 [O15511-1]

ARPC5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review