PELI1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_0042098Biological processT cell proliferation
GO_0060544Biological processregulation of necroptotic process
GO_0043331Biological processresponse to dsRNA
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0034145Biological processpositive regulation of toll-like receptor 4 signaling pathway
GO_0060546Biological processnegative regulation of necroptotic process
GO_0008592Biological processregulation of Toll signaling pathway
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0042130Biological processnegative regulation of T cell proliferation
GO_0030890Biological processpositive regulation of B cell proliferation
GO_0070534Biological processprotein K63-linked ubiquitination
GO_1905168Biological processpositive regulation of double-strand break repair via homologous recombination
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0001819Biological processpositive regulation of cytokine production
GO_1904262Biological processnegative regulation of TORC1 signaling
GO_0034141Biological processpositive regulation of toll-like receptor 3 signaling pathway
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0032496Biological processresponse to lipopolysaccharide
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0034450Molecular functionubiquitin-ubiquitin ligase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePELI1
Protein nameE3 ubiquitin-protein ligase pellino homolog (EC 2.3.2.27)
E3 ubiquitin-protein ligase pellino homolog 1 (Pellino-1) (EC 2.3.2.27) (Pellino-related intracellular-signaling molecule) (RING-type E3 ubiquitin transferase pellino homolog 1)
SynonymsPRISM
hCG_22381
DescriptionFUNCTION: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation . Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 . Negatively regulates necroptosis by reducing RIPK3 expression . Mediates 'Lys-63'-linked ubiquitination of RIPK1 . .

FUNCTION: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. .

AccessionsQ53T26
Q96FA3
ENST00000358912.5