Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 34 studies | 29% ± 13% | |
macrophage | 24 studies | 33% ± 17% | |
B cell | 20 studies | 25% ± 6% | |
regulatory T cell | 17 studies | 33% ± 8% | |
classical monocyte | 16 studies | 24% ± 6% | |
plasma cell | 14 studies | 35% ± 12% | |
non-classical monocyte | 14 studies | 25% ± 8% | |
dendritic cell | 13 studies | 28% ± 8% | |
pericyte | 13 studies | 22% ± 6% | |
microglial cell | 13 studies | 46% ± 15% | |
memory B cell | 13 studies | 32% ± 15% | |
monocyte | 11 studies | 31% ± 14% | |
oligodendrocyte precursor cell | 11 studies | 30% ± 12% | |
myeloid cell | 11 studies | 34% ± 12% | |
endothelial cell of lymphatic vessel | 10 studies | 29% ± 15% | |
CD4-positive, alpha-beta T cell | 10 studies | 21% ± 5% | |
ciliated cell | 9 studies | 22% ± 7% | |
neutrophil | 9 studies | 27% ± 7% | |
T cell | 8 studies | 19% ± 4% | |
naive B cell | 8 studies | 33% ± 16% | |
endothelial cell of artery | 8 studies | 27% ± 8% | |
endothelial cell of vascular tree | 8 studies | 31% ± 21% | |
oligodendrocyte | 8 studies | 23% ± 6% | |
conventional dendritic cell | 7 studies | 22% ± 3% | |
epithelial cell | 6 studies | 35% ± 17% | |
smooth muscle cell | 6 studies | 20% ± 2% | |
mononuclear phagocyte | 5 studies | 29% ± 6% | |
plasmablast | 5 studies | 37% ± 15% | |
capillary endothelial cell | 5 studies | 20% ± 4% | |
type I pneumocyte | 5 studies | 24% ± 7% | |
vein endothelial cell | 5 studies | 36% ± 24% | |
squamous epithelial cell | 4 studies | 41% ± 19% | |
T follicular helper cell | 4 studies | 23% ± 4% | |
abnormal cell | 4 studies | 28% ± 8% | |
IgA plasma cell | 4 studies | 33% ± 17% | |
basal cell | 4 studies | 31% ± 17% | |
glutamatergic neuron | 4 studies | 31% ± 13% | |
leukocyte | 4 studies | 27% ± 12% | |
alveolar macrophage | 4 studies | 32% ± 7% | |
type II pneumocyte | 4 studies | 23% ± 4% | |
keratinocyte | 4 studies | 27% ± 4% | |
tissue-resident macrophage | 3 studies | 33% ± 13% | |
IgG plasma cell | 3 studies | 28% ± 5% | |
GABAergic neuron | 3 studies | 22% ± 2% | |
mast cell | 3 studies | 26% ± 7% | |
club cell | 3 studies | 31% ± 6% | |
fibroblast | 3 studies | 20% ± 4% | |
transit amplifying cell | 3 studies | 30% ± 20% | |
neuron | 3 studies | 35% ± 15% | |
CD4-positive, alpha-beta memory T cell | 3 studies | 23% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 3556.31 | 1444 / 1445 | 100% | 66.96 | 183 / 183 |
lung | 100% | 5589.97 | 578 / 578 | 100% | 58.34 | 1154 / 1155 |
intestine | 100% | 3066.00 | 966 / 966 | 99% | 38.58 | 523 / 527 |
uterus | 100% | 2650.18 | 170 / 170 | 97% | 32.87 | 444 / 459 |
bladder | 100% | 2071.33 | 21 / 21 | 96% | 32.21 | 486 / 504 |
brain | 96% | 1884.71 | 2532 / 2642 | 100% | 45.87 | 705 / 705 |
breast | 100% | 4930.61 | 459 / 459 | 95% | 27.98 | 1066 / 1118 |
prostate | 100% | 1662.21 | 244 / 245 | 94% | 20.05 | 471 / 502 |
stomach | 94% | 1781.99 | 337 / 359 | 99% | 38.14 | 284 / 286 |
thymus | 98% | 1911.08 | 640 / 653 | 91% | 34.79 | 549 / 605 |
kidney | 91% | 1501.98 | 81 / 89 | 88% | 28.04 | 794 / 901 |
skin | 85% | 3501.47 | 1542 / 1809 | 90% | 26.02 | 427 / 472 |
pancreas | 74% | 858.22 | 244 / 328 | 98% | 43.45 | 175 / 178 |
ovary | 66% | 816.05 | 118 / 180 | 99% | 27.22 | 425 / 430 |
adrenal gland | 79% | 891.17 | 203 / 258 | 73% | 18.68 | 169 / 230 |
liver | 75% | 1177.75 | 169 / 226 | 64% | 13.01 | 258 / 406 |
adipose | 100% | 4678.63 | 1204 / 1204 | 0% | 0 | 0 / 0 |
spleen | 100% | 4009.09 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 42.01 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 15.41 | 1 / 1 |
blood vessel | 100% | 2307.44 | 1330 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 97% | 6369.34 | 905 / 929 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 97% | 44.85 | 28 / 29 |
heart | 83% | 1206.09 | 716 / 861 | 0% | 0 | 0 / 0 |
muscle | 61% | 574.12 | 491 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 6% | 0.52 | 5 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006281 | Biological process | DNA repair |
GO_0042098 | Biological process | T cell proliferation |
GO_0060544 | Biological process | regulation of necroptotic process |
GO_0043331 | Biological process | response to dsRNA |
GO_0070936 | Biological process | protein K48-linked ubiquitination |
GO_0034145 | Biological process | positive regulation of toll-like receptor 4 signaling pathway |
GO_0060546 | Biological process | negative regulation of necroptotic process |
GO_0008592 | Biological process | regulation of Toll signaling pathway |
GO_0043123 | Biological process | positive regulation of canonical NF-kappaB signal transduction |
GO_0042130 | Biological process | negative regulation of T cell proliferation |
GO_0030890 | Biological process | positive regulation of B cell proliferation |
GO_0070534 | Biological process | protein K63-linked ubiquitination |
GO_1905168 | Biological process | positive regulation of double-strand break repair via homologous recombination |
GO_0031398 | Biological process | positive regulation of protein ubiquitination |
GO_0001819 | Biological process | positive regulation of cytokine production |
GO_1904262 | Biological process | negative regulation of TORC1 signaling |
GO_0034141 | Biological process | positive regulation of toll-like receptor 3 signaling pathway |
GO_0043161 | Biological process | proteasome-mediated ubiquitin-dependent protein catabolic process |
GO_0032496 | Biological process | response to lipopolysaccharide |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0035861 | Cellular component | site of double-strand break |
GO_0005634 | Cellular component | nucleus |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0034450 | Molecular function | ubiquitin-ubiquitin ligase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | PELI1 |
Protein name | E3 ubiquitin-protein ligase pellino homolog (EC 2.3.2.27) E3 ubiquitin-protein ligase pellino homolog 1 (Pellino-1) (EC 2.3.2.27) (Pellino-related intracellular-signaling molecule) (RING-type E3 ubiquitin transferase pellino homolog 1) |
Synonyms | PRISM hCG_22381 |
Description | FUNCTION: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation . Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 . Negatively regulates necroptosis by reducing RIPK3 expression . Mediates 'Lys-63'-linked ubiquitination of RIPK1 . . FUNCTION: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. . |
Accessions | Q53T26 Q96FA3 ENST00000358912.5 |