H2AX report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007283Biological processspermatogenesis
GO_0010212Biological processresponse to ionizing radiation
GO_0045739Biological processpositive regulation of DNA repair
GO_0006302Biological processdouble-strand break repair
GO_0006974Biological processDNA damage response
GO_0071480Biological processcellular response to gamma radiation
GO_0031507Biological processheterochromatin formation
GO_0006334Biological processnucleosome assembly
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0051321Biological processmeiotic cell cycle
GO_1990166Biological processprotein localization to site of double-strand break
GO_0090398Biological processcellular senescence
GO_0021987Biological processcerebral cortex development
GO_0000077Biological processDNA damage checkpoint signaling
GO_0000786Cellular componentnucleosome
GO_0016607Cellular componentnuclear speck
GO_0005813Cellular componentcentrosome
GO_0005657Cellular componentreplication fork
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0090734Cellular componentsite of DNA damage
GO_0000794Cellular componentcondensed nuclear chromosome
GO_0000781Cellular componentchromosome, telomeric region
GO_0001673Cellular componentmale germ cell nucleus
GO_0001741Cellular componentXY body
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0019899Molecular functionenzyme binding
GO_0042393Molecular functionhistone binding
GO_0031492Molecular functionnucleosomal DNA binding
GO_0140463Molecular functionchromatin-protein adaptor activity
GO_0030527Molecular functionstructural constituent of chromatin
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding
GO_0003684Molecular functiondamaged DNA binding

IV. Literature review

[source]
Gene nameH2AX
Protein nameHistone H2AX (H2a/x) (Histone H2A.X)
SynonymsH2AFX
DescriptionFUNCTION: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. .

AccessionsENST00000375167.1
ENST00000530167.2
P16104