Name | Number of supported studies | Average coverage | |
---|---|---|---|
natural killer cell | 13 studies | 20% ± 5% | |
endothelial cell | 12 studies | 22% ± 5% | |
epithelial cell | 6 studies | 27% ± 9% | |
adipocyte | 6 studies | 19% ± 5% | |
fibroblast | 6 studies | 21% ± 5% | |
endothelial cell of lymphatic vessel | 5 studies | 20% ± 6% | |
CD16-negative, CD56-bright natural killer cell, human | 5 studies | 20% ± 3% | |
CD16-positive, CD56-dim natural killer cell, human | 5 studies | 21% ± 3% | |
myeloid cell | 5 studies | 20% ± 3% | |
CD8-positive, alpha-beta memory T cell | 5 studies | 18% ± 2% | |
T cell | 4 studies | 17% ± 3% | |
glutamatergic neuron | 4 studies | 45% ± 19% | |
dendritic cell | 4 studies | 28% ± 14% | |
monocyte | 4 studies | 21% ± 3% | |
macrophage | 4 studies | 24% ± 4% | |
astrocyte | 4 studies | 21% ± 4% | |
mast cell | 3 studies | 18% ± 3% | |
classical monocyte | 3 studies | 22% ± 4% | |
leukocyte | 3 studies | 18% ± 2% | |
CD4-positive, alpha-beta T cell | 3 studies | 16% ± 1% | |
conventional dendritic cell | 3 studies | 25% ± 8% | |
mature NK T cell | 3 studies | 18% ± 1% | |
basal cell | 3 studies | 24% ± 9% | |
lymphocyte | 3 studies | 24% ± 3% | |
innate lymphoid cell | 3 studies | 19% ± 5% | |
GABAergic neuron | 3 studies | 47% ± 10% | |
alveolar macrophage | 3 studies | 28% ± 9% | |
gamma-delta T cell | 3 studies | 29% ± 7% | |
transit amplifying cell | 3 studies | 36% ± 16% | |
neuron | 3 studies | 25% ± 7% | |
interneuron | 3 studies | 36% ± 20% | |
oligodendrocyte | 3 studies | 21% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 1729.74 | 459 / 459 | 100% | 19.61 | 1118 / 1118 |
esophagus | 100% | 1457.03 | 1445 / 1445 | 100% | 29.65 | 183 / 183 |
intestine | 100% | 1414.28 | 966 / 966 | 100% | 14.39 | 526 / 527 |
bladder | 100% | 1651.38 | 21 / 21 | 100% | 18.53 | 502 / 504 |
uterus | 100% | 1722.51 | 170 / 170 | 100% | 29.66 | 457 / 459 |
prostate | 100% | 1362.89 | 245 / 245 | 99% | 11.41 | 499 / 502 |
lung | 100% | 1974.10 | 578 / 578 | 99% | 25.84 | 1147 / 1155 |
stomach | 100% | 1016.48 | 359 / 359 | 99% | 14.30 | 284 / 286 |
ovary | 100% | 1702.86 | 180 / 180 | 99% | 11.61 | 426 / 430 |
thymus | 100% | 1279.03 | 652 / 653 | 99% | 11.12 | 599 / 605 |
brain | 98% | 912.68 | 2585 / 2642 | 100% | 12.09 | 702 / 705 |
skin | 100% | 2362.41 | 1809 / 1809 | 97% | 12.61 | 458 / 472 |
pancreas | 97% | 636.49 | 318 / 328 | 99% | 14.07 | 176 / 178 |
kidney | 100% | 833.36 | 89 / 89 | 95% | 9.14 | 854 / 901 |
liver | 100% | 974.64 | 226 / 226 | 94% | 7.65 | 380 / 406 |
adrenal gland | 100% | 1117.66 | 258 / 258 | 91% | 6.71 | 210 / 230 |
adipose | 100% | 1922.04 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1686.02 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 17.75 | 29 / 29 |
spleen | 100% | 1424.95 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 46.72 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 13.08 | 1 / 1 |
muscle | 100% | 994.19 | 800 / 803 | 0% | 0 | 0 / 0 |
heart | 98% | 1046.38 | 841 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 91% | 1475.50 | 845 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 64% | 3.56 | 51 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0016567 | Biological process | protein ubiquitination |
GO_0006303 | Biological process | double-strand break repair via nonhomologous end joining |
GO_0036297 | Biological process | interstrand cross-link repair |
GO_0010212 | Biological process | response to ionizing radiation |
GO_0045739 | Biological process | positive regulation of DNA repair |
GO_0006302 | Biological process | double-strand break repair |
GO_0140861 | Biological process | DNA repair-dependent chromatin remodeling |
GO_0006974 | Biological process | DNA damage response |
GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
GO_0034244 | Biological process | negative regulation of transcription elongation by RNA polymerase II |
GO_0097680 | Biological process | double-strand break repair via classical nonhomologous end joining |
GO_0070534 | Biological process | protein K63-linked ubiquitination |
GO_0045190 | Biological process | isotype switching |
GO_0040029 | Biological process | epigenetic regulation of gene expression |
GO_0000151 | Cellular component | ubiquitin ligase complex |
GO_0032991 | Cellular component | protein-containing complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0035861 | Cellular component | site of double-strand break |
GO_0005634 | Cellular component | nucleus |
GO_0070530 | Molecular function | K63-linked polyubiquitin modification-dependent protein binding |
GO_0042393 | Molecular function | histone binding |
GO_0003682 | Molecular function | chromatin binding |
GO_0140852 | Molecular function | histone ubiquitin ligase activity |
GO_0140858 | Molecular function | histone H2AK15 ubiquitin ligase activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0031491 | Molecular function | nucleosome binding |
GO_0004842 | Molecular function | ubiquitin-protein transferase activity |
GO_0005515 | Molecular function | protein binding |
GO_0043130 | Molecular function | ubiquitin binding |
Gene name | RNF168 |
Protein name | RING-type E3 ubiquitin transferase (EC 2.3.2.27) E3 ubiquitin-protein ligase RNF168 (hRNF168) (EC 2.3.2.27) (RING finger protein 168) (RING-type E3 ubiquitin transferase RNF168) |
Synonyms | |
Description | FUNCTION: E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively). . |
Accessions | ENST00000437070.1 Q8IYW5 F8WD60 ENST00000318037.3 |