NABP2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NABP2 at tissue level.

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_1904355Biological processpositive regulation of telomere capping
GO_0010212Biological processresponse to ionizing radiation
GO_0006974Biological processDNA damage response
GO_0051972Biological processregulation of telomerase activity
GO_0007093Biological processmitotic cell cycle checkpoint signaling
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0044818Biological processmitotic G2/M transition checkpoint
GO_0070200Biological processestablishment of protein localization to telomere
GO_0070876Cellular componentSOSS complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000781Cellular componentchromosome, telomeric region
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0070182Molecular functionDNA polymerase binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0061730Molecular functionC-rich strand telomeric DNA binding
GO_0098505Molecular functionG-rich strand telomeric DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNABP2
Protein nameNucleic acid binding protein 2
SOSS complex subunit B1 (Nucleic acid-binding protein 2) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2B) (Sensor of single-strand DNA complex subunit B1) (Sensor of ssDNA subunit B1) (SOSS-B1) (Single-stranded DNA-binding protein 1) (hSSB1)
SynonymsLP3587
SSB1
OBFC2B
DescriptionFUNCTION: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint . In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. .

AccessionsENST00000380198.6 [Q9BQ15-1]
ENST00000399713.6
Q9BQ15
C9JT95
ENST00000341463.5 [Q9BQ15-1]
ENST00000267023.9 [Q9BQ15-1]
ENST00000447747.5
C9JMP5