I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 4 studies | 25% ± 5% | |
| retinal cone cell | 3 studies | 25% ± 5% | |
| retinal rod cell | 3 studies | 21% ± 4% | |
| oligodendrocyte | 3 studies | 18% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 4 studies | 25% ± 5% | |
| retinal cone cell | 3 studies | 25% ± 5% | |
| retinal rod cell | 3 studies | 21% ± 4% | |
| oligodendrocyte | 3 studies | 18% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 1217.34 | 1445 / 1445 | 100% | 18.14 | 183 / 183 |
| prostate | 100% | 1407.98 | 245 / 245 | 100% | 23.21 | 502 / 502 |
| breast | 100% | 1463.10 | 459 / 459 | 100% | 29.43 | 1117 / 1118 |
| kidney | 100% | 1604.21 | 89 / 89 | 100% | 22.69 | 900 / 901 |
| brain | 100% | 1196.26 | 2638 / 2642 | 100% | 22.91 | 705 / 705 |
| uterus | 100% | 1508.55 | 170 / 170 | 100% | 20.70 | 458 / 459 |
| ovary | 100% | 1381.53 | 180 / 180 | 100% | 15.23 | 429 / 430 |
| thymus | 100% | 1696.35 | 653 / 653 | 100% | 25.75 | 603 / 605 |
| bladder | 100% | 1307.43 | 21 / 21 | 99% | 17.88 | 501 / 504 |
| lung | 99% | 1230.96 | 573 / 578 | 100% | 19.86 | 1155 / 1155 |
| pancreas | 100% | 1251.23 | 328 / 328 | 99% | 18.43 | 176 / 178 |
| adrenal gland | 100% | 1531.37 | 258 / 258 | 99% | 28.63 | 227 / 230 |
| liver | 100% | 923.83 | 226 / 226 | 99% | 13.17 | 400 / 406 |
| stomach | 100% | 1263.08 | 359 / 359 | 98% | 16.64 | 281 / 286 |
| intestine | 100% | 1502.50 | 966 / 966 | 98% | 16.68 | 517 / 527 |
| skin | 100% | 1474.30 | 1807 / 1809 | 97% | 23.55 | 458 / 472 |
| adipose | 100% | 1320.32 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 26.00 | 29 / 29 |
| spleen | 100% | 1806.76 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 20.91 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 5.82 | 1 / 1 |
| blood vessel | 100% | 1256.88 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 100% | 1050.42 | 802 / 803 | 0% | 0 | 0 / 0 |
| heart | 97% | 996.43 | 835 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 93% | 13.85 | 74 / 80 |
| peripheral blood | 76% | 1065.69 | 707 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006325 | Biological process | chromatin organization |
| GO_0006281 | Biological process | DNA repair |
| GO_0006974 | Biological process | DNA damage response |
| GO_0042325 | Biological process | regulation of phosphorylation |
| GO_0008156 | Biological process | negative regulation of DNA replication |
| GO_1990166 | Biological process | protein localization to site of double-strand break |
| GO_0033314 | Biological process | mitotic DNA replication checkpoint signaling |
| GO_0031573 | Biological process | mitotic intra-S DNA damage checkpoint signaling |
| GO_0000076 | Biological process | DNA replication checkpoint signaling |
| GO_0000077 | Biological process | DNA damage checkpoint signaling |
| GO_0005730 | Cellular component | nucleolus |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0031389 | Cellular component | Rad17 RFC-like complex |
| GO_0000781 | Cellular component | chromosome, telomeric region |
| GO_0035861 | Cellular component | site of double-strand break |
| GO_0005634 | Cellular component | nucleus |
| GO_0003689 | Molecular function | DNA clamp loader activity |
| GO_0003682 | Molecular function | chromatin binding |
| GO_0140463 | Molecular function | chromatin-protein adaptor activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | RAD17 |
| Protein name | Cell cycle checkpoint protein RAD17 RAD17 checkpoint clamp loader component Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog) Cell cycle checkpoint protein RAD17 (RAD17 checkpoint clamp loader component) |
| Synonyms | R24L |
| Description | FUNCTION: Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage . Has a weak ATPase activity required for binding to chromatin . Participates in the recruitment of the 9-1-1 (RAD1-RAD9-HUS1) complex and RHNO1 onto chromatin, and in CHEK1 activation . May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination . . |
| Accessions | H0Y9T7 ENST00000611523.4 ENST00000620889.4 A0A0G2JPT5 D6RHU1 ENST00000509734.5 [O75943-1] ENST00000621274.3 ENST00000612044.4 ENST00000611001.4 H0Y9J8 A0A0G2JNH5 ENST00000380774.7 [O75943-1] A0A0G2JP31 ENST00000616683.4 [O75943-2] ENST00000305138.8 [O75943-2] ENST00000513214.1 ENST00000507927.5 ENST00000354312.7 [O75943-2] ENST00000617338.4 D6RAW6 ENST00000508320.1 ENST00000521422.5 [O75943-3] ENST00000610770.4 ENST00000621806.4 ENST00000282891.10 [O75943-4] ENST00000345306.10 [O75943-2] ENST00000361732.6 [O75943-2] ENST00000358030.6 [O75943-3] ENST00000613281.4 D6RA84 O75943 ENST00000613417.4 A0A0G2JP78 ENST00000611548.4 ENST00000614140.4 ENST00000512785.5 ENST00000616488.2 ENST00000354868.10 [O75943-2] ENST00000616158.4 ENST00000506564.5 ENST00000610584.4 ENST00000616759.4 |
