RAD18 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_0006974Biological processDNA damage response
GO_0051865Biological processprotein autoubiquitination
GO_0006301Biological processpostreplication repair
GO_0051984Biological processpositive regulation of chromosome segregation
GO_0006513Biological processprotein monoubiquitination
GO_0042405Cellular componentnuclear inclusion body
GO_0005813Cellular componentcentrosome
GO_0005657Cellular componentreplication fork
GO_0005654Cellular componentnucleoplasm
GO_0097505Cellular componentRad6-Rad18 complex
GO_0016604Cellular componentnuclear body
GO_0005737Cellular componentcytoplasm
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0042802Molecular functionidentical protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0046872Molecular functionmetal ion binding
GO_0031593Molecular functionpolyubiquitin modification-dependent protein binding
GO_0000403Molecular functionY-form DNA binding
GO_0005515Molecular functionprotein binding
GO_0003684Molecular functiondamaged DNA binding

IV. Literature review

[source]
Gene nameRAD18
Protein nameRING-type E3 ubiquitin transferase (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RAD18)
E3 ubiquitin-protein ligase RAD18 (EC 2.3.2.27) (Postreplication repair protein RAD18) (hHR18) (hRAD18) (RING finger protein 73) (RING-type E3 ubiquitin transferase RAD18)
RAD18 E3 ubiquitin protein ligase
SynonymsRNF73
DescriptionFUNCTION: E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. .

AccessionsENST00000264926.7
F8WE49
F8WAZ7
ENST00000429790.1
C9J0Q4
F8WFA6
ENST00000421052.5
H7C0A5
ENST00000413832.1
ENST00000427329.5
Q9NS91
ENST00000415439.5
ENST00000418463.5
H7C3I2