HTATSF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_1990166Biological processprotein localization to site of double-strand break
GO_1903241Biological processU2-type prespliceosome assembly
GO_0005686Cellular componentU2 snRNP
GO_0005654Cellular componentnucleoplasm
GO_0035861Cellular componentsite of double-strand break
GO_0005681Cellular componentspliceosomal complex
GO_0005684Cellular componentU2-type spliceosomal complex
GO_0005634Cellular componentnucleus
GO_0003723Molecular functionRNA binding
GO_0160004Molecular functionpoly-ADP-D-ribose modification-dependent protein binding
GO_0140463Molecular functionchromatin-protein adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHTATSF1
Protein nameHIV-1 Tat specific factor 1
17S U2 SnRNP complex component HTATSF1 (HIV Tat-specific factor 1) (Tat-SF1)
Synonyms
DescriptionFUNCTION: Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs . The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing . Within the 17S U2 SnRNP complex, HTATSF1 is required to stabilize the branchpoint-interacting stem loop . HTATSF1 is displaced from the 17S U2 SnRNP complex before the stable addition of the 17S U2 SnRNP complex to the spliceosome, destabilizing the branchpoint-interacting stem loop and allowing to probe intron branch site sequences . Also acts as a regulator of transcriptional elongation, possibly by mediating the reciprocal stimulatory effect of splicing on transcriptional elongation . Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the recruitment of TOPBP1 to DNA damage sites . Mechanistically, HTATSF1 is (1) recruited to DNA damage sites in S-phase via interaction with poly-ADP-ribosylated RPA1 and (2) phosphorylated by CK2, promoting recruitment of TOPBP1, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination . .; FUNCTION: (Microbial infection) In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. .

AccessionsENST00000535601.5
Q5H918
ENST00000218364.5
ENST00000448450.5
O43719
ENST00000425695.5
Q5H919