TP53BP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0051260Biological processprotein homooligomerization
GO_0006303Biological processdouble-strand break repair via nonhomologous end joining
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0045830Biological processpositive regulation of isotype switching
GO_0006974Biological processDNA damage response
GO_0097680Biological processdouble-strand break repair via classical nonhomologous end joining
GO_0071481Biological processcellular response to X-ray
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_1990166Biological processprotein localization to site of double-strand break
GO_2000042Biological processnegative regulation of double-strand break repair via homologous recombination
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000077Biological processDNA damage checkpoint signaling
GO_0000776Cellular componentkinetochore
GO_0005657Cellular componentreplication fork
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_1990391Cellular componentDNA repair complex
GO_0005737Cellular componentcytoplasm
GO_0000781Cellular componentchromosome, telomeric region
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0035064Molecular functionmethylated histone binding
GO_0042393Molecular functionhistone binding
GO_0042162Molecular functiontelomeric DNA binding
GO_0003712Molecular functiontranscription coregulator activity
GO_0140566Molecular functionhistone reader activity
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0002039Molecular functionp53 binding
GO_0061649Molecular functionubiquitin-modified histone reader activity
GO_0005515Molecular functionprotein binding
GO_0003684Molecular functiondamaged DNA binding

IV. Literature review

[source]
Gene nameTP53BP1
Protein nameTumor suppressor p53-binding protein 1
Tumor protein p53 binding protein 1
TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)
Synonyms
DescriptionFUNCTION: Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis . Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 . In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites . Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites . Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs . Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 . .

AccessionsENST00000417342.1
H7C495
ENST00000434595.1
ENST00000382044.9 [Q12888-2]
Q12888
C9JXV0
ENST00000450115.6 [Q12888-3]
H7C151
ENST00000413546.1
ENST00000382039.7
H7C3N7
ENST00000467474.1
H7BZY0
ENST00000434561.1
A6NNK5
ENST00000263801.7 [Q12888-1]
Q3YL84
M0R142
ENST00000411772.5